[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582990":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":45,"locations":55,"responsibleParty":80,"collaborators":35,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":35,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":35,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":35,"overallStatus":58,"whyStopped":35,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"South Valley University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A","ACTIVE_COMPARATOR","About 20 patients with psoriasis",[13],"Drug: Methotrexate",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B","About 20 psoriatic arthritis",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Group C","PLACEBO_COMPARATOR","About 10 healthy control group",[23],"Drug: Placebo",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Methotrexate","1. Assess the response of psoriasis and psoriatic arthritis to Methotrexate.\n2. Assess the relation between Card14 gene(rs 34367357 ) Polymorphism in psoriatic and psoriatic arthritis patients and their clinical response to methotrexate",[9,15],[31],"Card14 gene(rs 34367357 )",{"type":26,"name":33,"description":33,"armGroupLabels":34,"otherNames":35},"Placebo",[19],null,[37,41],{"name":38,"affiliation":39,"role":40},"Essam El-Din Abd El-Aziz Mohamed Ahmed Nada, Professor","Dermatology, Venereology and Andrology Sohag university","STUDY_CHAIR",{"name":42,"affiliation":43,"role":44},"Eisa Mohammed Hegazy, Professor","• Dermatology Venereology & Andrology Faculty of Medicine, South valley University.","STUDY_DIRECTOR",[46,51],{"name":47,"role":48,"phone":49,"phoneExt":35,"email":50},"Marwa Naguib Ahmed, MSc","CONTACT","+201099283315","omarahmed331166@yahoo.com",{"name":52,"role":48,"phone":53,"phoneExt":35,"email":54},"Soheir Abdel-Hamid Ali","+201066877343","Soher.abdel-hamed@med.svu.edu.eg",[56],{"facility":57,"status":58,"city":59,"state":35,"zip":35,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Qina University hospital, South Valley University Hospital","RECRUITING","Qina","Egypt","EG",{"type":63,"coordinates":64},"Point",[65,66],32.72671,26.16418,{"lat":66,"lon":65},[69,73,77],{"name":70,"role":48,"phone":71,"phoneExt":35,"email":72},"Mohamed Hosny Hassan, Professor","+201098473605","mohammedhosnyhassaan@med.svu.edu.eg",{"name":74,"role":48,"phone":75,"phoneExt":35,"email":76},"Ebtehal Alaa El-Din Kotop Mohamed, Lecturer","+201066798383","Ebtehal_alaa@med.svu.edu.eg",{"name":78,"role":79,"phone":35,"phoneExt":35,"email":35},"Shimaa Saber Ahmed., M.D","PRINCIPAL_INVESTIGATOR",{"type":79,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Marwa Naguib Ahmed","Resident of Dermatology , venereology and andrology at Faculty of medicine","100582990","card14gene-rs34367357--polymorphism-in-egyptian-psoriatic-and-psoriatic-arthritis-patient-100582990",false,"NCT06870500","Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient","Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient and Its Relation With Response to Methotrexate","Inclusion Criteria:\n\n* Patients aged 18 years and above.\n* Patients having psoriasis diagnosed clinically and who have a severity grade of moderate to severe, defined as a Psoriasis Area and Severity Index (PASI) score from 5- 10 % of body surface area, and involvement of greater than 10% of the body surface area (BSA) with or without psoriatic arthritis\n\nExclusion Criteria:\n\n* Patients with other autoimmune conditions (e.g., rheumatoid arthritis, systemic lupus erythematosus).\n* Pregnancy and lactation.\n* Patients currently undergoing immunosuppressive or systemic therapies.\n* Patients with known genetic disorders affect immune system function.\n* Patients with liver or kidney impairment.\n* Patients with allergy or contraindication to methotrexate.\n* Patients with active or uncontrolled infections, including chronic infections like tuberculosis.","ALL","18 Years","50 Years",{"count":94,"type":95},50,"ESTIMATED","INTERVENTIONAL",[98],"NA","Psoriasis is a chronic, immune-mediated, multisystemic, inflammatory disease caused by the interaction of multiple susceptibility genes and environmental factors that affects 1-3% of the population worldwide .Psoriasis also is a chronic inflammatory skin disease characterized by scaly indurated erythema.\n\nPsoriatic arthritis (PsA) is an autoimmune and chronic musculoskeletal disorder that is associated with psoriasis of the skin . Its presentation can vary from subtle manifestations to highly destructive forms. Joint pain, stiffness and swelling are the most common symptoms.",[101],"Psoriatic Arthritis","2025-03-10",{"date":104,"type":105},"2025-03-11","ACTUAL",{"date":107,"type":105},"2025-03-05",{"date":109,"type":95},"2026-03-10",{"name":5,"class":6},1]