[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604813":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":20,"responsibleParty":37,"collaborators":10,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":10,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"University Hospital, Essen","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients referred for cerebral amyloid PET to clarify Alzheimer's disease",null,"The study population consists of patients who have been clinically referred for a cerebral amyloid PET examination to clarify a diagnosis of Alzheimer's disease.\n\nThe study population will undergo a comprehensive diagnostic evaluation, which includes:\n\n* An extension of the amyloid PET examination to include cardiac PET\u002FMRI imaging. No additional substances are applied and there is no additional radiation exposure.\n* A transthoracic echocardiogram, including strain analysis\n* A 12-lead electrocardiogram (EKG)",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"David Kersting, MD PhD","CONTACT","+49-201-723-2073","david.kersting@uk-essen.de",{"name":19,"role":15,"phone":10,"phoneExt":10,"email":10},"Stephan Settelmeier, MD",[21],{"facility":22,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"University Hospital Essen","RECRUITING","Essen","North Rhine-Westphalia","45147","Germany","DE",{"type":30,"coordinates":31},"Point",[32,33],7.01228,51.45657,{"lat":33,"lon":32},[36],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"type":38,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100604813","cardiac-amyloid-deposits-and-heart-dysfunction-in-alzheimers-disease-100604813",false,"NCT07154394","Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease","Investigation of Cardiac Amyloid Deposits as a Cause of Cardiac Dysfunction in Alzheimer's Disease (Untersuchung Von Kardialen Amyloidablagerungen Als Ursache Einer Funktionseinschränkung Des Herzens Bei Alzheimer Demenz)","Inclusion Criteria:\n\n* Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease\n* No contraindications to undergo an MRI examination\n* No contraindications to undergo an Amyloid PET scan\n\nExclusion Criteria:\n\n* Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)\n* Patients with pronounced cardiac preconditions\n* Pregnant and breastfeeding women","ALL","18 Years",{"count":49,"type":50},15,"ESTIMATED","OBSERVATIONAL","This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart.\n\nThe study will conduct additional PET\u002FMRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia.\n\nThis could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.",[54,55,56],"Dementia, Alzheimer Type","Mild Cognitive Impairment","Cardiac Amyloidosis","2025-08-26",{"date":59,"type":60},"2025-09-04","ACTUAL",{"date":62,"type":60},"2022-08-15",{"date":64,"type":50},"2025-09-14",{"name":5,"class":6},1]