[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616387":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":11,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Seoul National University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cardiac index guided hemodynamic management","EXPERIMENTAL",null,[13],"Procedure: Cardiac Index-Guided Hemodynamic Management",{"label":15,"type":16,"description":11,"interventionNames":17},"Blood pressure guided hemodynamic management","ACTIVE_COMPARATOR",[18],"Procedure: Blood Pressure-Guided Standard Hemodynamic Management",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Cardiac Index-Guided Hemodynamic Management","In the experimental arm, intraoperative hemodynamic management is guided by each patient's baseline cardiac index. Cardiac output is continuously monitored using the LiDCO system after arterial line insertion. Baseline cardiac index is calibrated using transthoracic echocardiography, and intraoperative fluids and vasoactive agents are adjusted to maintain cardiac index within ±20% of baseline. Standard anesthesia monitoring is provided to all patients.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Blood Pressure-Guided Standard Hemodynamic Management","In the control arm, intraoperative hemodynamic management follows conventional blood pressure-guided practice. After arterial line placement, the LiDCO device remains connected but the display is concealed during anesthesia. Fluids and vasoactive medications are adjusted according to standard MAP-based management. Standard anesthesia monitoring is provided to all patients.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Jung-Bin Park","CONTACT","820220723664","jb4001@snu.ac.kr",[36],{"facility":37,"status":38,"city":39,"state":11,"zip":11,"country":40,"countryCode":11,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Seoul National University Children's Hospital","RECRUITING","Seoul","South Korea",{"type":42,"coordinates":43},"Point",[44,45],126.9784,37.566,{"lat":45,"lon":44},[48],{"name":49,"role":32,"phone":50,"phoneExt":11,"email":34},"Park","8220723664",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Eun-hee Kim","professor","100616387","cardiac-index-guided-intraoperative-hemodynamic-management-in-pediatric-moyamoya-surgery-100616387",false,"NCT07304947","Cardiac Index-Guided Intraoperative Hemodynamic Management in Pediatric Moyamoya Surgery","Personalized Cardiac Index-Guided Intraoperative Hemodynamic Management to Improve Postoperative Outcomes in Pediatric Patients With Moyamoya Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Pediatric patients \\\u003C18 years undergoing EDAS for Moyamoya disease under general anesthesia\n\nExclusion Criteria:\n\n* ASA physical status 4-5\n* Emergency surgery\n* Known cardiovascular disease\n* Any condition judged inappropriate by investigators","ALL","1 Month","18 Years",{"count":66,"type":67},94,"ESTIMATED","INTERVENTIONAL",[70],"NA","This prospective randomized controlled trial evaluates whether individualized cardiac index-guided intraoperative hemodynamic management reduces postoperative transient ischemic episodes in pediatric patients undergoing encephaloduroarteriosynangiosis (EDAS) for Moyamoya disease. Patients are randomized 1:1 to goal-directed fluid therapy based on baseline cardiac index versus standard arterial pressure-based management. The primary outcome is the incidence of transient ischemic episodes during hospitalization.",[73],"Moyamoya Disease","2025-12-11",{"date":76,"type":77},"2025-12-26","ACTUAL",{"date":79,"type":67},"2025-12-02",{"date":81,"type":67},"2029-01-31",{"name":5,"class":6},1]