[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628060":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":30,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Swiss Paraplegic Research, Nottwil","NETWORK",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"AD+",null,"Spinal Cord Injury, above Th6, AIS A or B, Autonomic Dysreflexia",{"label":13,"type":10,"description":14,"interventionNames":10},"AD-","Spinal Cord Injury, below Th10, AIS A or B, no Autonomic Dysreflexia",[16],{"name":17,"affiliation":18,"role":19},"Jens Wöllner, Prof. Dr. med.","Swiss Paraplegic Centre","PRINCIPAL_INVESTIGATOR",[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Jörg Krebs, PD Dr. med. vet. PhD","CONTACT","+41 41 939 5946","joerg.krebs@paraplegie.ch",{"name":27,"role":23,"phone":28,"phoneExt":10,"email":29},"Florian van Dellen, Dr. sc.","+41 41 939 6542","florian.vandellen@paraplegie.ch",[31],{"facility":32,"status":10,"city":33,"state":10,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Swiss Paraplegic Center","Nottwil","6207","Switzerland","CH",{"type":38,"coordinates":39},"Point",[40,41],8.13774,47.13469,{"lat":41,"lon":40},[44],{"name":45,"role":23,"phone":46,"phoneExt":10,"email":47},"Jens Wöllner, PD Dr. med.","+41939 59 41","jens.wöllner@paraplegie.ch",{"type":49,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100628060","cardiac-morphology-and-function-in-individuals-with-autonomic-dysreflexia-100628060",false,"NCT07456722","Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia","Assessment of Cardiac Morphology and Function in Individuals With and Without Autonomic Dysreflexia Due to Spinal Cord Injury or Disease","HEART_REMOD_AD","Inclusion Criteria:\n\n* adults aged 18 years or older\n* long-term (\\>10 years), motor-complete SCI\u002FD (AIS A and B)\n* Group A (24 individuals): high-level (\\>Th6) SCI\u002FD and autonomic dysreflexia\n* Group B (24 individuals): low-level (\\\u003CTh10) SCI\u002FD without autonomic dysreflexia\n* signed informed consent\n\nExclusion Criteria:\n\n* congenital heart defects\n* valvular disease(s)\n* cardiomyopathy\n* medium to severe arrhythmia\n* myocardial infarction\n* comorbidities causing morphologic heart changes including primary hypertension, aortic stenosis\n* comorbidities causing arterial hypertension\n* use of anti-hypertensive treatment\n* smokers\n* individuals after sacral deafferentation surgery\n* pregnancy\n* active implanted medical devices\n* claustrophobia\n* inability to comply with the measurement procedures","ALL","18 Years",{"count":61,"type":62},48,"ESTIMATED","OBSERVATIONAL","This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI\u002FD) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI\u002FD (above Th6) who have AD and 24 individuals with low-level SCI\u002FD (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling.\n\nAll 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI\u002FD population.",[66,67,68],"Autonomic Dysreflexia","Spinal Cord Injuries and Disorders (SCI\u002FD)","Cardiac Remodeling","NOT_YET_RECRUITING","2026-03-09",{"date":72,"type":73},"2026-03-11","ACTUAL",{"date":75,"type":62},"2026-05-01",{"date":77,"type":62},"2028-10-31",{"name":5,"class":6},1]