[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100169296":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":20,"locations":30,"responsibleParty":233,"collaborators":235,"id":241,"slug":242,"hasResults":243,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":243,"sex":249,"minAge":250,"maxAge":251,"enrollmentInfo":252,"targetDuration":10,"studyType":255,"phases":10,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":270},{"fullName":5,"class":6},"Ottawa Heart Institute Research Corporation","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"CS screened as underlying etiology",null,"1. Patients with active Clinically Manifest CS\n2. Patients diagnosed with extra-cardiac sarcoidosis and being screened for CS",[13,16,18],{"name":14,"affiliation":5,"role":15},"David Birnie, MD","PRINCIPAL_INVESTIGATOR",{"name":17,"affiliation":5,"role":15},"Pablo Nery, MD",{"name":19,"affiliation":5,"role":15},"Rob Beanlands, MD",[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Janine E Ryan, BA(H), CCRP","CONTACT","613-696-7000","17077","jryan@ottawaheart.ca",{"name":14,"role":23,"phone":28,"phoneExt":10,"email":29},"613-696-7269","dbirnie@ottawaheart.ca",[31,49,62,76,91,107,120,133,150,163,177,189,200,216],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Libin Cardiovascular Institute of Alberta","RECRUITING","Calgary","Alberta","T2N 2T9","Canada","CA",{"type":40,"coordinates":41},"Point",[42,43],-114.08529,51.05011,{"lat":43,"lon":42},[46,48],{"name":47,"role":23,"phone":10,"phoneExt":10,"email":10},"Russell Quinn, MD",{"name":47,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":50,"status":33,"city":51,"state":35,"zip":52,"country":37,"countryCode":38,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"University of Alberta Hospital","Edmonton","T6G 2B7",{"type":40,"coordinates":54},[55,56],-113.46871,53.55014,{"lat":56,"lon":55},[59,61],{"name":60,"role":23,"phone":10,"phoneExt":10,"email":10},"Tomascz Hruczkowski, MD",{"name":60,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":63,"status":33,"city":64,"state":65,"zip":66,"country":37,"countryCode":38,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"St. Paul's Hospital","Vancouver","British Columbia","V5Z 1M9",{"type":40,"coordinates":68},[69,70],-123.11934,49.24966,{"lat":70,"lon":69},[73,75],{"name":74,"role":23,"phone":10,"phoneExt":10,"email":10},"Shanta Chakrabarti, MD",{"name":74,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":77,"status":33,"city":78,"state":79,"zip":80,"country":37,"countryCode":38,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"QEII Health Sciences Center","Halifax","Nova Scotia","B3H 3A7",{"type":40,"coordinates":82},[83,84],-63.57688,44.64269,{"lat":84,"lon":83},[87,89],{"name":88,"role":23,"phone":10,"phoneExt":10,"email":10},"Kim Anderson, MD",{"name":90,"role":15,"phone":10,"phoneExt":10,"email":10},"Ciorsti MacIntyre, MD",{"facility":92,"status":33,"city":93,"state":94,"zip":95,"country":37,"countryCode":38,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Hamilton Health Sciences Centre","Hamilton","Ontario","L8L 2X2",{"type":40,"coordinates":97},[98,99],-79.84963,43.25011,{"lat":99,"lon":98},[102,104,106],{"name":103,"role":23,"phone":10,"phoneExt":10,"email":10},"Jeff Healey, MD",{"name":105,"role":23,"phone":10,"phoneExt":10,"email":10},"Gerard Cox, MD",{"name":103,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":108,"status":33,"city":109,"state":94,"zip":110,"country":37,"countryCode":38,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"London Health Sciences Centre","London","N6A 5A5",{"type":40,"coordinates":112},[113,114],-81.23304,42.98339,{"lat":114,"lon":113},[117,119],{"name":118,"role":23,"phone":10,"phoneExt":10,"email":10},"Lorne Gula, MD",{"name":118,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":121,"status":33,"city":122,"state":94,"zip":123,"country":37,"countryCode":38,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Southlake Regional Health Centre","Newmarket","L3Y 2P9",{"type":40,"coordinates":125},[126,127],-79.46631,44.05011,{"lat":127,"lon":126},[130,132],{"name":131,"role":23,"phone":10,"phoneExt":10,"email":10},"Bernice Tsang, MD",{"name":131,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":134,"status":33,"city":135,"state":94,"zip":136,"country":37,"countryCode":38,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"University of Ottawa Heart Institute","Ottawa","K1Y 4W7",{"type":40,"coordinates":138},[139,140],-75.69812,45.41117,{"lat":140,"lon":139},[143,145,149],{"name":144,"role":23,"phone":24,"phoneExt":25,"email":26},"Janine E Ryan, BA H",{"name":146,"role":23,"phone":24,"phoneExt":147,"email":148},"Tammy Knight","19080","tknight@ottawaheart.ca",{"name":14,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":151,"status":33,"city":152,"state":94,"zip":153,"country":37,"countryCode":38,"cosmosGeoPoint":154,"geoPoint":158,"contacts":159},"Toronto General Hospital","Toronto","M5G 2C4",{"type":40,"coordinates":155},[156,157],-79.39864,43.70643,{"lat":157,"lon":156},[160,162],{"name":161,"role":23,"phone":10,"phoneExt":10,"email":10},"Andrew Ha, MD",{"name":161,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":164,"status":33,"city":165,"state":166,"zip":167,"country":37,"countryCode":38,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Montreal Heart Institute","Montreal","Quebec","H1T 1C8",{"type":40,"coordinates":169},[170,171],-73.58781,45.50884,{"lat":171,"lon":170},[174,176],{"name":175,"role":23,"phone":10,"phoneExt":10,"email":10},"Lena Rivard, MD",{"name":175,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":178,"status":179,"city":165,"state":166,"zip":180,"country":37,"countryCode":38,"cosmosGeoPoint":181,"geoPoint":183,"contacts":184},"Centre Hospitalier de l\"Universite de Montreal-Hotel Dieu","NOT_YET_RECRUITING","H2W 1T8",{"type":40,"coordinates":182},[170,171],{"lat":171,"lon":170},[185,187],{"name":186,"role":23,"phone":10,"phoneExt":10,"email":10},"Julie Fleury, RN",{"name":188,"role":15,"phone":10,"phoneExt":10,"email":10},"Benoit Coutu, MD",{"facility":190,"status":33,"city":165,"state":166,"zip":191,"country":37,"countryCode":38,"cosmosGeoPoint":192,"geoPoint":194,"contacts":195},"McGill University Health Centre","H3G 1A4",{"type":40,"coordinates":193},[170,171],{"lat":171,"lon":170},[196,198],{"name":197,"role":23,"phone":10,"phoneExt":10,"email":10},"Fiorella Rafti",{"name":199,"role":15,"phone":10,"phoneExt":10,"email":10},"Martin L Bernier, MD",{"facility":201,"status":33,"city":202,"state":203,"zip":204,"country":37,"countryCode":38,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Prairie Vascular Research Inc-Regina General Hospital","Regina","Saskatchewan","S4P 0W5",{"type":40,"coordinates":206},[207,208],-104.6178,50.45008,{"lat":208,"lon":207},[211,214],{"name":212,"role":23,"phone":10,"phoneExt":10,"email":213},"Kendra Townsend","Ktownsend.pvri@gmail.com",{"name":215,"role":15,"phone":10,"phoneExt":10,"email":10},"Andrea Lavoie, MD",{"facility":217,"status":33,"city":218,"state":10,"zip":219,"country":220,"countryCode":221,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Hokkaido University","Sapporo","060-8638","Japan","JP",{"type":40,"coordinates":223},[224,225],141.35,43.06667,{"lat":225,"lon":224},[228,232],{"name":229,"role":23,"phone":230,"phoneExt":10,"email":231},"Ichizo Tsujino, MD","81-11-706-5911","itsujino@med.hokudai.ac.jp",{"name":229,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":234,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[236,239],{"name":237,"class":238},"Ontario Ministry of Health and Long Term Care","OTHER_GOV",{"name":240,"class":238},"Canadian Institutes of Health Research (CIHR)","100169296","cardiac-sarcoidosis-multi-center-prospective-cohort-100169296",false,"NCT01477359","Cardiac Sarcoidosis Multi-Center Prospective Cohort","Cardiac Sarcoidosis Multi-Center Prospective Cohort Study","CHASM-CS","Inclusion Criteria:\n\nTo diagnose Clinically Manifest CS all following criteria must be met:\n\n(i) Positive biopsy\\* for Sarcoid (either EMB or extra-cardiac) AND\u002FOR (ii) CT Chest highly suggestive of pulmonary sarcoidosis AND (iii) one or more of the following clinical features:\n\n* advanced conduction system disease (sustained Mobitz II AV block or third degree AV block)\n* non- sustained or sustained ventricular arrhythmia\n* ventricular dysfunction (LVEF \\\u003C 50% and\u002For RVEF \\\u003C 40%) AND (iv) No alternative explanation for clinical features AND (v) FDG-PET suggestive of active CS\n\nTo diagnose clinically silent CS all of the following criteria must be met\n\n(i) Biopsy proven extra-cardiac sarcoidosis\n\nAND\u002FOR (ii) CT Chest highly suggestive of pulmonary sarcoidosis\n\nAND (iii) CMR suggestive of cardiac sarcoidosis\n\nAND (iv) Does not have criteria for clinically manifest CS ie. should not have any of following\n\n* advanced conduction system disease (sustained Mobitz II AV block or third degree AV block)\n* non- sustained or sustained ventricular arrhythmia\n* ventricular dysfunction (LVEF \\\u003C 50% and\u002For RVEF \\\u003C 40%)\n\nPatients with negative CMR will be designated as 'extra-cardiac sarcoidosis with no evidence of CS' and followed as control\n\nExclusion Criteria:\n\n* unable or unwilling to provide informed consent\n* patients who are pregnant or lactating\n* patients with known claustrophobia\n* age \\\u003C 18 years","ALL","18 Years","99 Years",{"count":253,"type":254},1500,"ESTIMATED","OBSERVATIONAL","Recent data has shown that sarcoidosis, presenting initially with cardiac manifestations (CS) of either conduction system disease or cardiomyopathy and sustained VT, is not uncommon. A Canadian physician survey found that most physicians do not investigate for CS as a possibility in these situations. Thus many patients with clinically important CS are going un-diagnosed. A study from Finland showed that missing the diagnosis of CS in these patients' leads to significant mortality and morbidity.\n\nThere are no published clinical consensus guidelines on treatment of CS. Corticosteroid therapy is advocated by most experts. This is based on very modest data from small retrospective observational studies using variable definitions of clinical response. The effect of corticosteroid treatment on the clinical course of CS has not been studied in prospective studies and will be one of the aims of this project. Recent physician surveys regarding CS, in Canada and the US, found that current clinical practice varies widely. The 2008 American College of Cardiology\u002FAmerican Heart Association\u002FHeart Rhythm society guidelines recommend implantation of a defibrillator (Class IIa recommendation) to prevent sudden cardiac death. The most recent Canadian device therapy guidelines do not mention CS.\n\nA multi-center collaborative approach to study CS is greatly needed.\" The investigators propose exactly that i.e. a multi-center prospective cohort to start to answer clinical questions. The investigators have formed the CANADIAN CARDIAC SARCOIDOSIS RESEARCH GROUP. The group includes respirologists with an interest in sarcoidosis, cardiac electrophysiologists, cardiac imaging specialists with extensive experience in imaging of sarcoidosis and biostatisticians. The research will be in two phases; a registry of current diagnostic approaches, treatment and prognosis, and a randomized clinical trial of the effect of corticosteroid treatment on the clinical course of cardiac sarcoidosis.",[258],"Cardiac Sarcoidosis",[260],"Sarcoidosis","2026-06-23",{"date":263,"type":264},"2026-06-24","ACTUAL",{"date":266,"type":264},"2012-08",{"date":268,"type":254},"2035-12",{"name":5,"class":6},14]