[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558752":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":29,"centralContacts":34,"locations":42,"responsibleParty":60,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":24,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Bispebjerg Hospital","OTHER",[8,14],{"label":9,"type":6,"description":10,"interventionNames":11},"Group randomized to begin with MRI","Group is randomized to begin with MRI and have PET\u002FCT performed later on the same day",[12,13],"Procedure: MRI","Procedure: PET\u002FCT",{"label":15,"type":6,"description":16,"interventionNames":17},"Group randomized to begin with PET\u002FCT","Group is randomized to begin with PET\u002FCT and have MRI performed later on the same day",[12,13],[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","MRI","MRI will be performed",[9,15],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"PET\u002FCT","PET\u002FCT will be performed",[9,15],[30],{"name":31,"affiliation":32,"role":33},"Ali Asmar, MD, PhD","Bispebjerg Hospital, Department of Clinical Physiology and Nuclear Medicine","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Peter Sørensen, MD","CONTACT","+4530516279","peter.soerensen@regionh.dk",{"name":31,"role":37,"phone":24,"phoneExt":24,"email":41},"ali.asmar@regionh.dk",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Bispebjerg Hospital, Department of Clinical Physiology & Nuclear Medicine","RECRUITING","Copenhagen","Capital Region","2400","Denmark","DK",{"type":52,"coordinates":53},"Point",[54,55],12.56553,55.67594,{"lat":55,"lon":54},[58,59],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},{"name":31,"role":37,"phone":24,"phoneExt":24,"email":41},{"type":33,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ali Asmar","Chief Physician, Associate Professor","100558752","cardio-and-renovascular-effects-of-isometric-exercise-in-the-healthy-human-measured-by-petct-and-mri-100558752",false,"NCT06555211","Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET\u002FCT and MRI","Cardio and Renovascular Effects of Static Muscle Work in the Healthy Human - Measured With Finapres® and Positron Emission Tomography (PET) Using 15-oxygen Labeled Water as Tracer Compared to Magnetic Resonance (MR)","Inclusion Criteria:\n\n* Normal health stated through medical questionnaire, examination and blood samples.\n\nExclusion Criteria:\n\n* Immunosuppressive treatment\n* Alcohol abuse\n* Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors\n* Medical treatment affecting insulin secretion or cardiovascular endpoints\n* Liver disease\n* Decreased kidney function\n* Severe claustrophobia\n* Elements incompatible with MR.",true,"MALE","18 Years","60 Years",{"count":75,"type":76},10,"ESTIMATED","INTERVENTIONAL",[79],"NA","This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET\u002FCT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique.\n\nThe study will determine:\n\n* Total renal blood flow and regional renal perfusion at baseline (rest) and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* The coefficient of variation of renal blood flow and regional renal perfusion measurements at baseline and during isometric muscle exercise of the upper arm, using PET\u002FCT (with 15-oxygen labeled water as a tracer) and MRI.\n* Regional renal oxygenation and oxygen extraction at baseline and during isometric muscle exercise of the upper arm using MRI.\n* The coefficient of variation on regional renal oxygenation and oxygen extraction measurements at baseline and during isometric muscle exercise of the upper arm using MRI.",[82],"Kidneys",[84,85,86,87],"Total renal blood flow","Regional renal perfusion","Regional renal oxygenation","Renal oxygen extraction","2024-08-12",{"date":90,"type":91},"2024-08-15","ACTUAL",{"date":93,"type":91},"2024-05-07",{"date":95,"type":76},"2024-12",{"name":5,"class":6},1]