[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638762":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":24,"responsibleParty":43,"collaborators":24,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":24,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":24,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":72,"whyStopped":24,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":24},{"fullName":5,"class":6},"Penn State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Adults","EXPERIMENTAL","Adults with normal BMI (18.5 -24.9 kg\u002Fm2) and optimal\u002Fnear optimal LDL-C (≤ 129 mg\u002FdL).",[13,14],"Other: Full-fat dairy","Other: Low-fat dairy",{"label":16,"type":10,"description":17,"interventionNames":18},"Adults at risk for cardiometabolic diseases","Adults with overweight\u002Fobesity (25-39.9 kg\u002Fm2) and elevated LDL-C (130-190 mg\u002FdL",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Full-fat dairy","3 cup-equivalents\u002Fday of full-fat dairy (milk, yogurt \\& cheese)",[16,9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Low-fat dairy","3 cup-equivalents\u002Fday of low-fat dairy (milk, yogurt \\& cheese)",[16,9],[30],{"name":31,"affiliation":32,"role":33},"Kristina Petersen, PhD","The Pennsylvania State University","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":24,"email":38},"CONTACT","814-865-7206","kup63@psu.edu",{"name":40,"role":36,"phone":41,"phoneExt":24,"email":42},"Stacey Meily","814-863-8622","sas117@psu.edu",{"type":33,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Kristina Petersen PhD, APD, FAHA","Associate Professor","100638762","cardiometabolic-effects-of-low-fat-and-full-fat-dairy-100638762",false,"NCT07605442","Cardiometabolic Effects of Low-Fat and Full-Fat Dairy","Cardiometabolic Effects of Low-Fat and Full-Fat Dairy in Healthy and Cardiometabolically At-Risk Adults","Inclusion Criteria:\n\n* BMI 18.5 to 39.9 kg\u002Fm2\n* LDL-C ≤190 mg\u002FdL assessed by the Modified Sampson-NIH Equation\n* Currently consume milk, yogurt, and\u002For cheese daily\n* Willing to eat 3 servings of dairy (milk, yogurt, cheese) for two 6-week periods during the study\n\nExclusion Criteria:\n\n* Hemoglobin \\\u003C13.2 g\u002FdL for men or \\\u003C 11.7 g\u002FdL for women at screening\n* Fasting triglycerides \\>350 mg\u002FdL at screening\n* ≥10% change in body weight within the 6 months prior to enrollment\n* Blood pressure \\>140\u002F90 mmHg at screening\n* Fasting glucose ≥126 mg\u002FdL\n* Type 1 or type 2 diabetes\n* Takes any (prescription or over-the-counter) anti-hypertensive, lipid-lowering, glucose-lowering or anti-inflammatory drugs, or drugs that alter body weight\n* Intake of supplements that affect the outcomes of interest (i.e., lipids, blood pressure, glucose, body weight, inflammation and microbiome) and are unwilling to cease during the study period.\n* Unwilling to refrain from starting to take any supplements, vitamins, nutritional products, or health foods that are not prescribed by a doctor for the duration of the study\n* History of liver, kidney, or autoimmune disease\n* Prior cardiovascular event (e.g., stroke, heart attack)\n* Current pregnancy or intention of pregnancy within the next 12 months\n* Lactation within the prior 6 months\n* Dairy allergy\u002Fintolerance\u002Fsensitivity\u002Fdislike\n* Antibiotic use within the prior four weeks\n* Oral steroid use within the prior four weeks\n* Use of tobacco or nicotine-containing products within the past 6 months\n* History of cancer at any site within the past 10 years (eligible if ≥10 years without recurrence) or non-melanoma skin cancer within the past 5 years (eligible if ≥5 years without recurrence)\n* Participation in another clinical trial within 60 days of baseline\n* Currently following a restricted or weight-loss diet\n* Prior bariatric surgery\n* Intake of \\>14 alcoholic drinks\u002Fweek and\u002For not willing to avoid alcohol consumption for 48 hours prior to test visits\n* Does not speak and\u002For understand English\n* Unwilling to refrain from donating blood and\u002For plasma during the study\n* Weight \\\u003C110 lb\n* Lactose intolerance or sensitivity\n* Unwilling to contact study staff before enrolling in other health-related research and avoid participating in any research that may interfere with this study\n* For individuals taking thyroid medication: abnormal thyroid stimulated hormone (TSH) concentration, or change in dose of thyroid medication within the last 6 months\n* Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements, including being able to come to attend visits",true,"ALL","25 Years","70 Years",{"count":58,"type":59},178,"ESTIMATED","INTERVENTIONAL",[62],"NA","The purpose of this study is to find out if full-fat dairy and low-fat dairy have similar effects on risk factors for heart disease and diabetes. During the study, participants will consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. Measures will be taken to evaluate blood cholesterol, blood sugar, body weight, inflammation, blood pressure, heart health and dietary intake at the beginning and end of each 6 week period.",[65],"Cardiovascular (CV) Risk",[67,68,69,70,71],"dairy","diet","nutrition","LDL-cholesterol","cardiovascular disease","NOT_YET_RECRUITING","2026-05-18",{"date":75,"type":76},"2026-05-26","ACTUAL",{"date":78,"type":59},"2026-09-08",{"date":80,"type":59},"2028-08-31",{"name":5,"class":6}]