[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505052":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":25,"responsibleParty":104,"collaborators":107,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":133,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":10,"studyType":139,"phases":10,"briefSummary":140,"conditions":141,"keywords":147,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"Cambridge University Hospitals NHS Foundation Trust","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Pregnancy ~3000 participants",null,"Actively planning to conceive within approximately 12 months of study registration. No previous pregnancies.",{"label":13,"type":10,"description":14,"interventionNames":10},"Non-Pregnancy ~500 participants","Not planning to conceive within 18 months of study registration. No previous pregnancies.",[16],{"name":17,"affiliation":5,"role":18},"Ian Wilkinson, MD","PRINCIPAL_INVESTIGATOR",[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Heike Templin","CONTACT","0044 1223 250874","cuh.poppycctu@nhs.net",[26,41,52,65,74,83,92],{"facility":5,"status":27,"city":28,"state":10,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"RECRUITING","Cambridge","CB2 0QQ","United Kingdom","UK",{"type":33,"coordinates":34},"Point",[35,36],0.11667,52.2,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: Carmel McEniery",{"facility":42,"status":27,"city":43,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":44,"geoPoint":48,"contacts":49},"NHS Greater Glasgow and Clyde","Glasgow",{"type":33,"coordinates":45},[46,47],-4.25763,55.86515,{"lat":47,"lon":46},[50],{"name":51,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: Christian Delles",{"facility":53,"status":54,"city":55,"state":10,"zip":56,"country":30,"countryCode":31,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"University College London Hospitals NHS Foundation Trust","NOT_YET_RECRUITING","London","NW1 2BU",{"type":33,"coordinates":58},[59,60],-0.12574,51.50853,{"lat":60,"lon":59},[63],{"name":64,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: David Williams",{"facility":66,"status":54,"city":55,"state":10,"zip":67,"country":30,"countryCode":31,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"King's College Hospital NHS Foundation Trust","SE5 9RS",{"type":33,"coordinates":69},[59,60],{"lat":60,"lon":59},[72],{"name":73,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: Lucilla Poston",{"facility":75,"status":54,"city":55,"state":10,"zip":76,"country":30,"countryCode":31,"cosmosGeoPoint":77,"geoPoint":79,"contacts":80},"St George's University Hospitals NHS Foundation Trust","SW17 0QT",{"type":33,"coordinates":78},[59,60],{"lat":60,"lon":59},[81],{"name":82,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: Asma Khalil",{"facility":84,"status":27,"city":55,"state":10,"zip":85,"country":30,"countryCode":31,"cosmosGeoPoint":86,"geoPoint":88,"contacts":89},"Imperial College Healthcare NHS Trust","W2 1NY",{"type":33,"coordinates":87},[59,60],{"lat":60,"lon":59},[90],{"name":91,"role":22,"phone":10,"phoneExt":10,"email":10},"Site PI: Christoph Lees",{"facility":93,"status":54,"city":94,"state":10,"zip":95,"country":30,"countryCode":31,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Manchester University NHS Foundation Trust","Manchester","M13 9WL",{"type":33,"coordinates":97},[98,99],-2.23743,53.48095,{"lat":99,"lon":98},[102],{"name":103,"role":22,"phone":10,"phoneExt":10,"email":10},"Laura Ormesher",{"type":18,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dr Ian B Wilkinson","Head of Division, Division of Experimental Medicine & Immunotherapeutics",[108,110,112,114,116,118,120,122],{"name":109,"class":6},"University of Cambridge",{"name":111,"class":6},"University of Bristol",{"name":113,"class":6},"University College, London",{"name":115,"class":6},"King's College London",{"name":117,"class":6},"Imperial College London",{"name":119,"class":6},"St George's, University of London",{"name":121,"class":6},"University of Glasgow",{"name":123,"class":6},"Wellcome Trust","100505052","cardiometabolic-health-in-first-time-pregnancy-100505052",false,"NCT05856318","Cardiometabolic Health in First Time Pregnancy","Preconception to pOst-partum Study of Cardiometabolic Health in Primigravid PregnancY","POPPY","Pregnancy Arm Inclusion Criteria:\n\nTo be included in the trial the participant must:\n\n* Nulliparous (no previous pregnancy beyond 20 weeks' gestation)\n* Actively considering pregnancy within approximately 12 months\n* Aged between 18 and 45 years\n* Ability to consent and willing to participate\n\nPregnancy Arm Exclusion Criteria:\n\nThe presence of any of the following will preclude participant inclusion:\n\n* Currently pregnant\n* Established infertility\n* Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)\n* Assigned male sex at birth\n* Autoimmune disease (e.g. rheumatoid arthritis, lupus)\n* Thrombophilia\n* Type 1 diabetes\n* Known advanced chronic kidney disease (stages 4-5)\n* Malignant hypertension\n* Clinically manifest CVD (e.g. previous myocardial infarction, stroke)\n* Active cancer\u002Fbeing treated for cancer currently (other than skin cancer)\n* Any other condition preventing full participation in the study\n\nNon-Pregnancy Arm Inclusion criteria\n\nTo be included in the trial the participant must:\n\n* Nulliparous (no previous pregnancy beyond 20 weeks' gestation)\n* Not planning to conceive during next 18 months\n* Aged between 18 and 45 years\n* Ability to consent and willing to participate\n\nNon-Pregnancy Exclusion Criteria\n\nThe presence of any of the following will preclude participant inclusion:\n\n* Currently pregnant\n* Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)\n* Assigned male sex at birth\n* Autoimmune disease (e.g. rheumatoid arthritis, lupus)\n* Thrombophilia\n* Type 1 diabetes\n* Known advanced chronic kidney disease (stages 4-5)\n* Malignant hypertension\n* Clinically manifest CVD (e.g. previous myocardial infarction, stroke)\n* Active cancer\u002Fbeing treated for cancer currently (other than skin cancer)\n* Any other condition preventing full participation in the study",true,"FEMALE","18 Years","45 Years",{"count":137,"type":138},3500,"ESTIMATED","OBSERVATIONAL","Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy.\n\nThis study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.",[142,143,144,145,146],"Cardiometabolic Health","Pregnancy Related","Diabetes","Placental; Syndrome, Dysfunction","Heart Diseases",[148,149,150,151,152,153,154,155,156],"cardiometabolic","pregnancy","diabetes","childbirth","placental syndrome","heart disease","nulliparous","CVD risk","cardiovascular","2024-04-05",{"date":159,"type":160},"2024-04-09","ACTUAL",{"date":162,"type":160},"2023-05-24",{"date":164,"type":138},"2052-12",{"name":5,"class":6},7]