[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520584":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":11,"responsibleParty":33,"collaborators":11,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":11,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":11,"enrollmentInfo":45,"targetDuration":11,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":11},{"fullName":5,"class":6},"St. Joseph's Centre, Poland","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cardioneuroablation of right anterior ganglionated plexus","EXPERIMENTAL",null,[13],"Procedure: Cardioneuroablation of right anterior ganglionated plexus",{"label":15,"type":16,"description":11,"interventionNames":17},"Pulmonary vein isolation","ACTIVE_COMPARATOR",[18],"Procedure: Pulmonary vein isolation",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Right anterior ganglionated plexus will be localized using anatomical approach. Radiofrequency energy will be delivered until heart rate acceleration \\>30% is achieved or if radiofrequency time exceeds 120 seconds.",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Application sites near the ostia of pulmonary veins will be determined. Radiofrequency energy will be delivered using point-by-point technique. After applications, the acute PVI endpoint will be confirmed by the elimination of PV potentials and lack of capture during pacing from the ablation lines.",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Piotr Futyma","CONTACT","+48 533 503 044","piotr.futyma@gmail.com",{"type":34,"investigatorFullName":29,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Professor","100520584","cardioneuroablation-vs-pulmonary-vein-isolation-in-treatment-of-paroxysmal-atrial-fibrillation-100520584",false,"NCT06058468","Cardioneuroablation vs Pulmonary Vein Isolation in Treatment of Paroxysmal Atrial Fibrillation","Cardioneuroablation of Right Anterior Ganglionated Plexus vs Pulmonary Vein Isolation in Patients With Paroxysmal Atrial Fibrillation and Enhanced Vagal Tone","Inclusion Criteria:\n\n* Paroxysmal atrial fibrillation documented in ECG or Holter monitoring\n* Deceleration capacity \\>7.5ms\n* Life expectancy more than 1 year\n* Age ≥18 years\n\nExclusion Criteria:\n\n* Permanent AF lasting more than one year or persistent AF lasting more than 7 days\n* AF secondary to electrolyte imbalance, thyroid disease, alcohol abuse, or other non-heart related causes\n* Anteroposterior dimension of the left atrium in the echocardiography ≥43mm\n* Clinically significant arrhythmias other than AF\n* Significant valvular disease\n* Valve prosthesis\n* Heart failure III or IV Class in New York Heart Association Classification\n* Previous ablation of atrial fibrillation or atrial flutter\n* History of a patent foramen ovale\u002Fatrial septal defect closure\n* History of left atrial appendage closure\n* Atrial myxoma\n* Presence of a cardiac pacemaker, defibrillator or cardiac resynchronization therapy device\n* History of pericarditis\n* Congenital heart disease\n* History of bleeding or coagulation disorders\n* Contraindications to oral anticoagulation\n* Contraindications to computed tomography or magnetic resonance imaging\n* Pregnancy or breast-feeding\n* BMI\\>31\n* History of transplantation\n* Severe lung disease\n* Chronic renal failure defined as estimated glomerular filtration rate (eGFR) \\\u003C30 mL\u002Fmin\u002Fm2\n* Cancer\n* Significant infection\n* Life expectancy less than one year\n* Mental disorders\n* Lack of informed consent to participate in the trial","ALL","18 Years",{"count":46,"type":47},160,"ESTIMATED","INTERVENTIONAL",[50],"NA","The goal of this study is to compare effectiveness of cardioneuroablation of right anterior ganglionated plexus and pulmonary vein isolation in patients with enhanced vagal tone expressed as deceleration capacity \\>7.5ms.",[53],"Atrial Fibrillation Paroxysmal",[55,56,57],"Atrial Fibrillation","Vagally-mediated","Cardioneuroablation","NOT_YET_RECRUITING","2023-09-27",{"date":61,"type":62},"2023-09-29","ACTUAL",{"date":64,"type":47},"2024-01",{"date":66,"type":47},"2029-06",{"name":5,"class":6}]