[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100453801":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":53,"collaborators":56,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":10,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Maryland, Baltimore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cardiac Sugery Patients Requiring Cardiopulmonary >1hour",null,"Patients admitted for a complex cardiac surgery, heart valve replacement and\u002For CABG surgery requiring CPB \\>1hour",[13],"Other: Blood and urine collection",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Blood and urine collection","No intervention - Biological specimen collection",[9],[20],{"name":21,"affiliation":22,"role":23},"Paul Buehler, PhD","University of Maryland","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Paul W Buehler, PhD","CONTACT","14107065171","pbuehler@som.umaryland.edu",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},"Tobi Rowden, RN","4107064061","trowden@som.umaryland.edu",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Center for Blood Oxygen Transport and Hemostasis","RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-76.61219,39.29038,{"lat":47,"lon":46},[50,52],{"name":26,"role":27,"phone":51,"phoneExt":10,"email":29},"410-706-5171",{"name":31,"role":27,"phone":32,"phoneExt":10,"email":33},{"type":23,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Paul Buehler","Research Faculty",[57],{"name":58,"class":59},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100453801","cardiopulmonary-bypass-induced-red-blood-cell-lysis-100453801",false,"NCT05189262","Cardiopulmonary Bypass Induced Red Blood Cell Lysis","Extra-Cellular Hemoglobin, Organ Injury in Extended Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Admitted to UMMC for cardiac procedure\n* Age: \\>\u002F=18 y.o TO 88 y.o.\n* Undergoing CPB \\>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery.\n\nExclusion Criteria:\n\n* Pregnant\n* Non English speaking\n* Unable to consent or have Legally Authorized Representative (LAR) assent to study","ALL","18 Years","88 Years",{"count":71,"type":72},150,"ESTIMATED","OBSERVATIONAL","Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.",[76,77,78],"Cardiopulmonary Bypass","Cardiac Surgery","Kidney Injury, Acute","2025-08-13",{"date":81,"type":82},"2025-08-19","ACTUAL",{"date":84,"type":82},"2022-03-22",{"date":86,"type":72},"2027-12-01",{"name":5,"class":6},1]