[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548514":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":10,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"SURVIVOR",null,"A survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital.\n\nand Control: Voluntarily taking part in this study because you are a relative, friend or employee of St. Jude Children's Research Hospital.",[13],"Device: Near Infrared Spectroscopy (NIRS)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Near Infrared Spectroscopy (NIRS)","NIRS is a portable, non-invasive, brain imaging device.",[9],[21],{"name":22,"affiliation":23,"role":24},"Nicholas Phillips, PhD","St. Jude","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","888-226-4343","referralinfo@stjude.org",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Memphis","Tennessee","38105","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-90.04898,35.14953,{"lat":42,"lon":41},[45,46],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":22,"role":24,"phone":10,"phoneExt":10,"email":10},{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100548514","cardiopulmonary-function-and-cerebral-blood-flow-in-hodgkin-lymphoma-survivors-100548514",false,"NCT06421987","Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors","Inclusion Criteria:\n\nHL Survivors\n\n* Completed bleomycin and\u002For thoracic radiation therapy for HL at SJCRH.\n* \\\u003C21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy.\n* SJLIFE or ACT\u002FSJLIFE participants\n* English language proficiency.\n\nCommunity Controls\n\n* SJLIFE control.\n* ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors.\n\nExclusion Criteria:\n\nHL Survivors\n\n* History of cranial or total-body irradiation therapy.\n* History of intrathecal or high dose intravenous antimetabolite therapy.\n* History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.",true,"ALL","18 Years",{"count":59,"type":60},100,"ESTIMATED","OBSERVATIONAL","SURVIVORS\n\nStudy participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors.\n\nPrimary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. .\n\nSecondary Objectives To examine the degree of CO2 clearance (DLCO\u002FETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity.\n\nCONTROLS\n\nVolunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee\u002Faffiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.",[64],"Hodgkin Lymphoma, Adult","2026-04-21",{"date":67,"type":68},"2026-04-23","ACTUAL",{"date":70,"type":68},"2024-05-06",{"date":72,"type":60},"2027-12",{"name":5,"class":6},1]