[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641699":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":24,"responsibleParty":40,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":10,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":10,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Medical University of Warsaw","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"MIS-C group",null,"Children and young adults 5 years after MIS-C",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy controls","Children and young adults without significant chronic disease, frequency-matched to the MIS-C group by age, sex, and BMI.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Weronika Woźniak-Szewczyk, MD","CONTACT","+48 22 317 9231","wwozniakszewczyk@gmail.com",{"name":22,"role":18,"phone":19,"phoneExt":10,"email":23},"Magdalena Okarska-Napierała, MD PhD","magdalena.okarska-napierala@wum.edu.pl",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Medical University of Warsaw Children's Clinical Hospital","RECRUITING","Warsaw","Masovian Voivodeship","Poland","PL",{"type":33,"coordinates":34},"Point",[35,36],21.01178,52.22977,{"lat":36,"lon":35},[39],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100641699","cardiovascular-assessment-5-years-after-mis-c-100641699",false,"NCT07659847","Cardiovascular Assessment 5 Years After MIS-C","Cardiovascular Evaluation 5 Years After Multisystem Inflammatory Syndrome in Children (MIS-C)","Inclusion Criteria:\n\n* For the MIS-C group: History of MIS-C diagnosed according to World Health Organization (WHO) criteria\n* For all participants: Written informed consent from a parent or legal guardian and, where applicable, assent\u002Fconsent from participants aged 16 years or older \u002F\n\nExclusion Criteria:\n\nMIS-C group:\n\n1. Known heart disease, including congenital heart disease.\n2. Significant chronic disease affecting growth, development, or daily functioning.\n\nControl group:\n\n1. Elimination diet.\n2. Competitive athletic training.\n3. Known heart disease, including congenital heart disease.\n4. Significant chronic disease affecting growth, development, or daily functioning.",true,"ALL",{"count":52,"type":53},90,"ESTIMATED","OBSERVATIONAL","Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection that frequently affects the cardiovascular system. Although acute cardiac abnormalities usually resolve, the long-term cardiovascular consequences of MIS-C remain uncertain. Previous follow-up of this cohort 2 years after MIS-C identified signs of subclinical cardiovascular abnormalities compared with healthy controls.\n\nThis cross-sectional study aims to evaluate cardiovascular health in individuals 5 years after MIS-C. Participants with a history of MIS-C will be compared with age- and sex-matched healthy controls using cardiovascular imaging, vascular assessments, cardiopulmonary exercise testing, and biomarkers of endothelial injury.",[57,58],"Multisystem Inflammatory Syndrome in Children (MIS-C)","SARS-CoV-2 Infection",[60,61,62,63,64,57,65],"Pediatric Inflammatory Multisystem Syndrome (PIMS)","SARS-CoV-2","Endothelial Dysfunction","Cardiovascular Health","Long-Term Outcomes","Arterial Stiffness","2026-06-15",{"date":68,"type":69},"2026-06-22","ACTUAL",{"date":71,"type":69},"2025-11-22",{"date":73,"type":53},"2027-03-31",{"name":5,"class":6},1]