[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562348":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":36,"centralContacts":40,"locations":45,"responsibleParty":240,"collaborators":10,"id":242,"slug":243,"hasResults":244,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":250,"sex":251,"minAge":252,"maxAge":10,"enrollmentInfo":253,"targetDuration":10,"studyType":256,"phases":10,"briefSummary":257,"conditions":258,"keywords":262,"overallStatus":65,"whyStopped":10,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":281},{"fullName":5,"class":6},"Hellenic Institute for the Study of Sepsis","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy controls",null,"Controls with no or one comorbidity, predisposing to significant CV events and without a medical history of severe pneumonia.",[13],"Other: Blood samples and Oropharyngeal swab",{"label":15,"type":10,"description":16,"interventionNames":17},"CVRD controls","Controls with comorbidities predisposing to major CV events and without a medical history of severe pneumonia",[13,18],"Other: Six-minute walk test, Spirometry, ECG, Heart ultrasound and cardiopulmonary exercise stress testing, Completion of questionnaires of symptoms",{"label":20,"type":10,"description":21,"interventionNames":22},"COVID-19 survivors","Patients cured of acute COVID-19",[13,18],{"label":24,"type":10,"description":25,"interventionNames":26},"sCAP survivors","Patients cured of severe community-acquired pneumonia",[13,18],[28,32],{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"Blood samples and Oropharyngeal swab","Blood samples: EDTA-plasma (proteome, metabolome and lipidome) and PBMCs (transcriptome, epigenome, immune-phenotype and genetic polymorphism)",[20,15,9,24],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":10},"Six-minute walk test, Spirometry, ECG, Heart ultrasound and cardiopulmonary exercise stress testing, Completion of questionnaires of symptoms","* Spirometry for forced expiratory volume in the first, second, total lung capacity and diffusion capacity of carbon monoxide.\n* ECG, Heart ultrasound and cardiopulmonary exercise stress testing:\n\n  * NYHA\n  * Rhythm or conduction abnormality (yes\u002Fno)\n  * Left ventricular ejection fraction (%)\n  * VO2Max",[20,15,24],[37],{"name":38,"affiliation":5,"role":39},"Prof. Evangelos Giamarellos-Bourboulis","STUDY_CHAIR",[41],{"name":38,"role":42,"phone":43,"phoneExt":10,"email":44},"CONTACT","00302105831994","egiamarel@med.uoa.gr",[46,63,77,87,97,107,117,127,137,147,157,167,174,184,194,207,220,230],{"facility":47,"status":48,"city":49,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"2nd Department of Internal Medicine, University General Hospital of Alexandroupolis","NOT_YET_RECRUITING","Alexandroupoli","Greece","GR",{"type":53,"coordinates":54},"Point",[55,56],25.87644,40.84995,{"lat":56,"lon":55},[59],{"name":60,"role":42,"phone":61,"phoneExt":10,"email":62},"Assoc. Prof. Periklis Panagopoulos","00302551351592","ppanago@med.duth.gr",{"facility":64,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"10th Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases","RECRUITING","Athens",{"type":53,"coordinates":68},[69,70],23.72784,37.98376,{"lat":70,"lon":69},[73],{"name":74,"role":42,"phone":75,"phoneExt":10,"email":76},"Dr. Ilias Kainis","00302107771118","elikas60@gmail.com",{"facility":78,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"1st Department of Internal Medicine, General Hospital of Athens G. GENNIMATAS",{"type":53,"coordinates":80},[69,70],{"lat":70,"lon":69},[83],{"name":84,"role":42,"phone":85,"phoneExt":10,"email":86},"Dr Georgios Adamis","00302132032535","geo.adamis@gmail.com",{"facility":88,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S.",{"type":53,"coordinates":90},[69,70],{"lat":70,"lon":69},[93],{"name":94,"role":42,"phone":95,"phoneExt":10,"email":96},"Dr. Vasiliki Tzavara","00302132068843","vtzavara2015@gmail.com",{"facility":98,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"1st Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO",{"type":53,"coordinates":100},[69,70],{"lat":70,"lon":69},[103],{"name":104,"role":42,"phone":105,"phoneExt":10,"email":106},"Dr Charilaos Samaras","00302132163959","xarisamar@gmail.com",{"facility":108,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":109,"geoPoint":111,"contacts":112},"1st Intensive Care Clinic of the Medical School of the University of Athens, Evangelismos General Hospital",{"type":53,"coordinates":110},[69,70],{"lat":70,"lon":69},[113],{"name":114,"role":42,"phone":115,"phoneExt":10,"email":116},"Prof. Ioannis Kalomenidis","00302132043307","ikalom@med.uoa.gr",{"facility":118,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"1st University Department of Internal Medicine, General Hospital of Athens LAIKO",{"type":53,"coordinates":120},[69,70],{"lat":70,"lon":69},[123],{"name":124,"role":42,"phone":125,"phoneExt":10,"email":126},"Prof. Michael Samarkos","0030213 2061693","msamarkos@gmail.com",{"facility":128,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":129,"geoPoint":131,"contacts":132},"1st University Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases",{"type":53,"coordinates":130},[69,70],{"lat":70,"lon":69},[133],{"name":134,"role":42,"phone":135,"phoneExt":10,"email":136},"Assoc. Prof. Nikoletta Rovina","00302107763452","nikrovina@med.uoa.gr",{"facility":138,"status":48,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":139,"geoPoint":141,"contacts":142},"2nd Department of Internal Medicine, General Hospital of Voula ASKLEPIEIO",{"type":53,"coordinates":140},[69,70],{"lat":70,"lon":69},[143],{"name":144,"role":42,"phone":145,"phoneExt":10,"email":146},"Dr. Apostolos Maras","00302132163967","dr_tolismaras@yahoo.gr",{"facility":148,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":149,"geoPoint":151,"contacts":152},"2nd Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases",{"type":53,"coordinates":150},[69,70],{"lat":70,"lon":69},[153],{"name":154,"role":42,"phone":155,"phoneExt":10,"email":156},"Dr. Aimilia Tsaroucha","00302107773508","emilygeola@yahoo.gr",{"facility":158,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":159,"geoPoint":161,"contacts":162},"3rd University Department of Internal Medicine, Sotiria Athens Hospital of Chest Diseases",{"type":53,"coordinates":160},[69,70],{"lat":70,"lon":69},[163],{"name":164,"role":42,"phone":165,"phoneExt":10,"email":166},"Assoc. Prof. Garyfallia Poulakou","00302107763439","gpoulakou@gmail.com",{"facility":168,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":169,"geoPoint":171,"contacts":172},"4th Department of Internal Medicine, ATTIKON University General Hospital",{"type":53,"coordinates":170},[69,70],{"lat":70,"lon":69},[173],{"name":38,"role":42,"phone":43,"phoneExt":10,"email":44},{"facility":175,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":176,"geoPoint":178,"contacts":179},"Intensive Care Unit, General Hospital of Voula ASKLEPIEIO",{"type":53,"coordinates":177},[69,70],{"lat":70,"lon":69},[180],{"name":181,"role":42,"phone":182,"phoneExt":10,"email":183},"Dr Aikaterini Ioakeimidou","00302132163223","katioakim@gmail.com",{"facility":185,"status":65,"city":66,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":186,"geoPoint":188,"contacts":189},"Out-patients clinic, General Hospital of Voula ASKLEPIEIO",{"type":53,"coordinates":187},[69,70],{"lat":70,"lon":69},[190],{"name":191,"role":42,"phone":192,"phoneExt":10,"email":193},"Dr Sofia Nikolakopoulou","00306944479683","sofnikol@yahoo.gr",{"facility":195,"status":48,"city":196,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"1st Department of Internal Medicine, Thriasio General Hospital of Elefsina","Elefsina",{"type":53,"coordinates":198},[199,200],23.54295,38.04135,{"lat":200,"lon":199},[203],{"name":204,"role":42,"phone":205,"phoneExt":10,"email":206},"Dr. Styliani Symbardi","00302132028497","lianasympa@hotmail.com",{"facility":208,"status":48,"city":209,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"1st Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki","Thessaloniki",{"type":53,"coordinates":211},[212,213],22.93493,40.64072,{"lat":213,"lon":212},[216],{"name":217,"role":42,"phone":218,"phoneExt":10,"email":219},"Prof. Simeon Metallidis","00302313303110","metallidissimeon@yahoo.gr",{"facility":221,"status":48,"city":209,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":222,"geoPoint":224,"contacts":225},"Intensive Care Unit 2, AHEPA University General Hospital of Thessaloniki",{"type":53,"coordinates":223},[212,213],{"lat":213,"lon":212},[226],{"name":227,"role":42,"phone":228,"phoneExt":10,"email":229},"Assoc. Prof. Eleni Argyriadou","00302313303868","argiriadouhelena@hotmail.gr",{"facility":231,"status":48,"city":209,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":232,"geoPoint":234,"contacts":235},"Intensive Care Unit, \"Ippokrateion\" General Hospital of Thessaloniki",{"type":53,"coordinates":233},[212,213],{"lat":213,"lon":212},[236],{"name":237,"role":42,"phone":238,"phoneExt":10,"email":239},"Dr. Eleni Mouloudi","00302313312358","elmoulou@yahoo.gr",{"type":241,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100562348","cardiovascular-disease-progression-in-survivors-of-community-acquired-pneumonia-and-lung-infection-by-covid-19-100562348",false,"NCT06601998","Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Covid-19.","A Non-interventional, Prospective, Cross-sectional Study of Cardiovascular Disease Progression in Survivors of Community Acquired Pneumonia and Lung Infection by Sars-Cov-2","HOMI-LUNG CAP","Inclusion Criteria:\n\nGroup A (healthy controls)\n\n1. Adults (18 years or more) of both genders (Female\u002FMale: 50\u002F50 ratio)\n2. No history of severe pneumonia (sCAP, COVID-19 or HAP)\n3. Presence of no or one of the following comorbidities: obesity (defined as body mass index over 35 kg\u002Fm2), type 2 diabetes mellitus, hypercholesterolemia, essential arterial hypertension, or familial history of CVD.\n\nGroup B (CVRD controls)\n\n1. Adults (18 years or more) of both genders (Female\u002FMale ratio: 50\u002F50)\n2. No history of severe pneumonia (sCAP, COVID-19 or HAP)\n3. At least two of the following comorbidities: obesity (defined as body mass index over 35 kg\u002Fm2), type 2 diabetes mellitus, hypercholesterolemia, essential arterial hypertension, or familial history of CVD\n\nGroup C (COVID-19 survivors)\n\n1. Adults (18 years or more) of both genders (Female\u002FMale ratio: 50\u002F50)\n2. Survivors from severe COVID-19 pneumonia at hospital discharge; all patients had consolidation in chest X-ray or chest computed tomography during acute infection and were treated for pneumonia\n3. SoC treatment for acute COVID-19 with dexamethasone\n\nGroup D (sCAP survivors)\n\n1. Adults (18 years or more) of both genders\n2. Survivors from sCAP pneumonia; these patients may be either hospitalized in the ward with pO2FiO2 ratio less than 300 or require admission and hospitalization in the Intensive Care Unit.\n3. SoC treatment for sCAP with antibiotics\n\nExclusion Criteria:\n\nGroup A (healthy controls)\n\n1. Presence of two or more comorbidities\n2. Any other co-existing disorder generating CVRD symptoms\n3. Limited chance of survival for at least six months due to co-existing comorbidity (-ies) according to the judgement of the attending physicians\n4. Pregnancy or lactation\n\nGroup B (CVRD controls)\n\n1. Any other co-existing disorder generating CVRD symptoms\n2. Limited chance of survival for at least six months due to co-existing comorbidity (-ies) according to the judgement of the attending physicians\n3. Pregnancy or lactation\n\nGroup C (COVID-19 survivors)\n\n1. Medical history of severe congestive heart failure (Stage III-IV)\n2. Medical history of stage III or IV dyspnoea according to the New York Heart Association classification before the acute COVID-19\n3. Limited chance of survival for at least six months due to co-existing comorbidity (-ies) according to the judgement of the attending physicians\n4. Pregnancy or lactation\n\nGroup D (sCAP survivors)\n\n1. Medical history of severe congestive heart failure (Stage III-IV)\n2. Medical history of stage III or IV dyspnoea according to the New York Heart Association classification before the sCAP\n3. Limited chance of survival for at least six months due to co-existing comorbidity (-ies) according to the judgement of the attending physicians\n4. Pregnancy or lactation",true,"ALL","18 Years",{"count":254,"type":255},650,"ESTIMATED","OBSERVATIONAL","Pneumonia, which can be acquired in the community (including influenza and COVID-19), is a leading cause of mortality. The risk of severe cardiovascular diseases events (stroke, myocardial infarction, pulmonary embolism) increases after infections, but causal mechanisms are not understood yet. There is an essential need for improved understanding of the relationship between pneumonia and cardiovascular diseases and early identification of patients at risk of cardiovascular events to develop tailored therapies.\n\nThe overall concept underpinning \"Homi-lung\" is to investigate the time course of host-microbiome interactions during \\& after pneumonia to i) understand the causal relationship between trained immunity, microbiome dysbiosis and cardiovascular and respiratory diseases (CVRD) progressions, ii) define endotypes of pneumonia associated with response to treatment \\& CVRD history; iii) develop biomarkers to predict the individual response to the treatment \\& CVRD progression, and iv) preclinically validate therapeutical approaches for CVRD during \\& after pneumonia.",[259,260,261],"Pneumonia, Community-Acquired","COVID-19 Pneumonia","Cardiovascular Diseases",[263,264,265,266,267,268,269,270,271],"Covid-19","SARS-CoV-2","Lung infection","Cardiovascular disease","Respiratory disease","Endotypes","Biomarkers","Cardiorespiratory","Economic cost","2026-06-09",{"date":274,"type":275},"2026-06-10","ACTUAL",{"date":277,"type":275},"2024-11-08",{"date":279,"type":255},"2028-06-08",{"name":5,"class":6},18]