[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100491743":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":39,"collaborators":41,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":7,"studyType":58,"phases":7,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Oxford","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"History of being born to hypertensive or normal pregnancy","CLARITY is an observational study whereby participants will attend one 4-hr visit the Division of Cardiovascular Medicine, University of Oxford at the John Radcliffe Hospital in Oxford, with the option to split the study visit over two days for convenience.\n\nParticipants will be invited by the ALSPAC study team to attend a study visit in Oxford where the investigators will use MRI and other imaging modalities to study the brain, heart, liver, kidneys, and vasculature using standardised protocols. A dataset including information from previous follow-up of these cohorts and the detailed pregnancy data available within ALSPAC will be generated by the study team in Bristol and integrated with available data from the Oxford cohorts.",[13],{"name":14,"affiliation":15,"role":16},"Adam J Lewandowski","Cardiovascular Clinical Research Facility","PRINCIPAL_INVESTIGATOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":7,"email":22},"Katie Suriano","CONTACT","01865 226845","clarity@cardiov.ox.ac.uk",[24],{"facility":5,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"RECRUITING","Oxford","Oxfordshire","OX3 9DU","United Kingdom","UK",{"type":32,"coordinates":33},"Point",[34,35],-1.25596,51.75222,{"lat":35,"lon":34},[38],{"name":19,"role":20,"phone":21,"phoneExt":7,"email":22},{"type":40,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[42],{"name":43,"class":6},"University of Bristol","100491743","cardiovascular-longitudinal-alspac-research-investigations-following-hypertensive-pregnancy-in-young-adulthood-100491743",false,"NCT05683093","Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood","Cardiovascular Longitudinal the Avon Longitudinal Study of Parents and Children (ALSPAC) Research Investigations Following Hypertensive Pregnancy in Young Adulthood","CLARITY","Inclusion Criteria:\n\n* Participant is willing and able to give informed consent for participation in the study\n* Male or female, aged 30 to 40 years at time of enrolment\n* Participant previously took part in the ALSPAC study\n* Able (in the investigator's opinion) and willing to comply with all study requirements\n* Adequate understanding of verbal and written English\n\nExclusion Criteria:\n\n* Pregnant or lactating when they are due to attend for study visit 1\n* Less than six months postpartum\n* Planning to donate blood within two weeks prior to study visit 1\n* Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study\n* Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status\n\nFor exclusion of MRI component only:\n\n* Unsuitable for MRI based on participant screening; the participant may still be included in other parts of the study","ALL","30 Years","40 Years",{"count":56,"type":57},200,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to understand more about why young people who were born to a hypertensive pregnancy may have increased risk of high blood pressure and are often at increased risk of heart and blood vessel disease later in life.",[61,62,63,64,65,66],"Young Adult","Hypertension in Pregnancy","Hypertension","Cardiovascular Diseases","Cerebrovascular Diseases","Vascular Diseases",[61,68,62,69,70],"Birth History","Cardiovascular Risk","Exercise Capacity","2023-01-05",{"date":73,"type":74},"2023-01-12","ACTUAL",{"date":76,"type":74},"2022-11-17",{"date":78,"type":57},"2027-01-31",{"name":5,"class":6},1]