[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100340330":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":36,"locations":44,"responsibleParty":250,"collaborators":252,"id":258,"slug":259,"hasResults":260,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":260,"sex":266,"minAge":267,"maxAge":24,"enrollmentInfo":268,"targetDuration":24,"studyType":271,"phases":272,"briefSummary":274,"conditions":275,"keywords":280,"overallStatus":206,"whyStopped":24,"lastUpdateSubmitDate":291,"lastUpdatePostDateStruct":292,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":299,"locationsCount":300},{"fullName":5,"class":6},"Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Primary prevention strategy","EXPERIMENTAL","Intensive cardiovascular monitoring focused on prevention and early diagnosis and treatment of cardiotoxicity based in cardio-onco-hematology teams involved in cancer patient care.",[13],"Other: Intensive cardiovascular monitoring",{"label":15,"type":6,"description":16,"interventionNames":17},"Secondary prevention strategy (control)","Current clinical practice: cardiac care is based on the onco-hematologist criteria.",[18],"Other: No intervention",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Intensive cardiovascular monitoring","Schedule of visits: Evaluation before starting chemotherapy, at three and six months and annually for five years (eight visits: baseline, 3rd and 6th month, 1st, 2nd, 3rd, 4th and 5th years).\n\nAssessment protocol: Anamnesis and physical examination; EKG; Echocardiogram; Biomarkers (troponin and natriuretic peptide); Structured counselling on healthy cardiac practices; Treatment optimization of cardiovascular risk factors and heart diseases; Quality of life (ECOG Performance status and Minnesota questionnaires); Interaction and management of patient care by the cardio-onco-hematology team. Moreover, cardiac MRI in centers participating in the CARTIER-MR sub-study.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"No intervention","Schedule of visits: Evaluation before starting chemotherapy, at three and six months and annually for five years (eight visits: baseline, 3rd and 6th month, 1st, 2nd, 3rd, 4th and 5th years).\n\nAssessment protocol: Anamnesis and physical examination; ECOG Performance status; cardiac patient care based on the onco-hematologist criteria",[15],[30,34],{"name":31,"affiliation":32,"role":33},"Pedro L Sánchez, Ph. D.","IBSAL-Instituto de Investigación Biomédica de Salamanca","STUDY_DIRECTOR",{"name":35,"affiliation":32,"role":33},"Ana Martín-García, Ph. D.",[37,42],{"name":31,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","923 291100","55356","plsanchez@saludcastillayleon.es",{"name":35,"role":38,"phone":39,"phoneExt":40,"email":43},"amartingarcia@usal.es",[45,66,82,97,112,128,141,152,164,176,188,204,219,235],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Hospital Clínico Universitario de Santiago de Compostela","NOT_YET_RECRUITING","Santiago de Compostela","A Coruña","15706","Spain","ES",{"type":54,"coordinates":55},"Point",[56,57],-8.54569,42.88052,{"lat":57,"lon":56},[60,64],{"name":61,"role":38,"phone":62,"phoneExt":24,"email":63},"Pilar Mazón-Ramos, MD","+34 981 950 000","pilarmazon@yahoo.es",{"name":61,"role":65,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"facility":67,"status":47,"city":68,"state":69,"zip":70,"country":51,"countryCode":52,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Hospital de Galdakao-Usansolo","Galdakao","Vizcaya","48960",{"type":54,"coordinates":72},[73,74],-2.8429,43.23073,{"lat":74,"lon":73},[77,81],{"name":78,"role":38,"phone":79,"phoneExt":24,"email":80},"Sonia Velasco, MD","+34 944 007 000","soniavelascodelcastillo@gmail.com",{"name":78,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":83,"status":47,"city":84,"state":24,"zip":85,"country":51,"countryCode":52,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Hospital Universitario Vall d´Hebron","Barcelona","08035",{"type":54,"coordinates":87},[88,89],2.15899,41.38879,{"lat":89,"lon":88},[92,96],{"name":93,"role":38,"phone":94,"phoneExt":24,"email":95},"Ignacio Ferreira-González, MD","+34 91 336 80 00","nachoferreira@secardiologia.es",{"name":93,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":98,"status":47,"city":99,"state":24,"zip":100,"country":51,"countryCode":52,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Hospital Universitario Reina Sofía","Córdoba","14004",{"type":54,"coordinates":102},[103,104],-4.77275,37.89155,{"lat":104,"lon":103},[107,111],{"name":108,"role":38,"phone":109,"phoneExt":24,"email":110},"Dolores Mesa, MD","+34 957 010 000","loladoctora@gmail.com",{"name":108,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":113,"status":47,"city":114,"state":24,"zip":115,"country":51,"countryCode":52,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Hospital Universitario de La Princesa","Madrid","28006",{"type":54,"coordinates":117},[118,119],-3.70256,40.4165,{"lat":119,"lon":118},[122,126],{"name":123,"role":38,"phone":124,"phoneExt":24,"email":125},"Fernando Alfonso-Manterola","+34 915 202 200","falf@hotmail.com",{"name":127,"role":65,"phone":24,"phoneExt":24,"email":24},"Fernando Alfonso-Manterola, Md",{"facility":129,"status":47,"city":114,"state":24,"zip":130,"country":51,"countryCode":52,"cosmosGeoPoint":131,"geoPoint":133,"contacts":134},"Hospital G. Universitario Gregorio Marañón","28009",{"type":54,"coordinates":132},[118,119],{"lat":119,"lon":118},[135,139],{"name":136,"role":38,"phone":137,"phoneExt":24,"email":138},"Eduardo Zatarain-Nicolás","+34 915 868 000","eduzatanico@gmail.com",{"name":140,"role":65,"phone":24,"phoneExt":24,"email":24},"Eduardo Zatarain-Nicolás, MD",{"facility":142,"status":47,"city":114,"state":24,"zip":143,"country":51,"countryCode":52,"cosmosGeoPoint":144,"geoPoint":146,"contacts":147},"Hospital Universitario Ramón y Cajal","28034",{"type":54,"coordinates":145},[118,119],{"lat":119,"lon":118},[148,151],{"name":149,"role":38,"phone":94,"phoneExt":24,"email":150},"Ana Pardo-Sanz, MD","anapardosanz0@gmail.com",{"name":149,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":153,"status":47,"city":114,"state":24,"zip":154,"country":51,"countryCode":52,"cosmosGeoPoint":155,"geoPoint":157,"contacts":158},"Hospital Universitario Fundación Jiménez Díaz","28040",{"type":54,"coordinates":156},[118,119],{"lat":119,"lon":118},[159,163],{"name":160,"role":38,"phone":161,"phoneExt":24,"email":162},"Luis F Navarro-del-Amo, MD","+34 915 504 800","fnavarro@gmail.com",{"name":160,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":165,"status":47,"city":114,"state":24,"zip":166,"country":51,"countryCode":52,"cosmosGeoPoint":167,"geoPoint":169,"contacts":170},"Hospital Universitario 12 de Octubre","28041",{"type":54,"coordinates":168},[118,119],{"lat":119,"lon":118},[171,175],{"name":172,"role":38,"phone":173,"phoneExt":24,"email":174},"Carmen Jiménez-López-Guarch, MD","+34 91 390 80 00","cjlguarch@gmail.com",{"name":172,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":177,"status":47,"city":114,"state":24,"zip":178,"country":51,"countryCode":52,"cosmosGeoPoint":179,"geoPoint":181,"contacts":182},"Hospital Universitario Puerta de Hierro","28222",{"type":54,"coordinates":180},[118,119],{"lat":119,"lon":118},[183,187],{"name":184,"role":38,"phone":185,"phoneExt":24,"email":186},"Cristina Mitroi, MD","+34 911 916 565","cristina_mitroi@hotmail.com",{"name":184,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":189,"status":47,"city":190,"state":24,"zip":191,"country":51,"countryCode":52,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Hospital Universitario Virgen de la Victoria","Málaga","29010",{"type":54,"coordinates":193},[194,195],-4.42034,36.72016,{"lat":195,"lon":194},[198,202],{"name":199,"role":38,"phone":200,"phoneExt":24,"email":201},"Juan J Gómez-Doblas","+34 951 032 000","jjgomezdoblas@gmail.com",{"name":203,"role":65,"phone":24,"phoneExt":24,"email":24},"Juan J Gómez-Doblas, MD",{"facility":205,"status":206,"city":207,"state":24,"zip":208,"country":51,"countryCode":52,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Complejo Asistencial Universitario de Salamanca","RECRUITING","Salamanca","37007",{"type":54,"coordinates":210},[211,212],-5.66388,40.96882,{"lat":212,"lon":211},[215,217,218],{"name":35,"role":38,"phone":216,"phoneExt":40,"email":43},"+34 923291100",{"name":35,"role":65,"phone":24,"phoneExt":24,"email":24},{"name":31,"role":65,"phone":24,"phoneExt":24,"email":24},{"facility":220,"status":47,"city":221,"state":24,"zip":222,"country":51,"countryCode":52,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Hospital Universitario Virgen del Rocío","Seville","41013",{"type":54,"coordinates":224},[225,226],-5.97317,37.38283,{"lat":226,"lon":225},[229,233],{"name":230,"role":38,"phone":231,"phoneExt":24,"email":232},"Gonzalo Baron-Esquivias","+34 955 012 000","gonzalo.baron.sspa@juntadeandalucia.es",{"name":234,"role":65,"phone":24,"phoneExt":24,"email":24},"Gonzalo Baron-Esquivias, MD",{"facility":236,"status":47,"city":237,"state":24,"zip":238,"country":51,"countryCode":52,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"Hospital Universitario Río Hortega","Valladolid","47012",{"type":54,"coordinates":240},[241,242],-4.72353,41.65541,{"lat":242,"lon":241},[245,249],{"name":246,"role":38,"phone":247,"phoneExt":24,"email":248},"Marina Revilla-Martínez, MD","+34 983 420 400","marinarema@hotmail.com",{"name":246,"role":65,"phone":24,"phoneExt":24,"email":24},{"type":251,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[253,255],{"name":254,"class":6},"Instituto de Investigación Biomédica de Salamanca",{"name":256,"class":257},"Instituto de Salud Carlos III","OTHER_GOV","100340330","cardiovascular-prevention-strategies-in-elderly-patients-with-cancer-cartier-clinical-trial-100340330",false,"NCT03711110","Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)","Cardiotoxicity in the Elderly. Comparative Clinical Trial Between Primary Versus Secondary Cardiovascular Prevention Strategies","CARTIER","Inclusion Criteria:\n\n* \\> 65 years old\n* Expected survival \\>1 year\n* Colon cancer, breast cancer, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia, myeloma\n* Signature on the informed consent\n\nExclusion Criteria:\n\n* Patients included in clinical trials will be excluded if they interfere with the CARTIER follow-up protocol. If they do not interfere they can be included\n* Patients who had received previous potentially cardiotoxic anticancer treatment","ALL","65 Years",{"count":269,"type":270},514,"ESTIMATED","INTERVENTIONAL",[273],"NA","The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive cardiovascular monitoring focused on prevention and early diagnosis and treatment of cardiotoxicity based in cardio-onco-hematology teams involved in cancer patient care) vs. secondary (current clinical practice where intensive cardiovascular monitoring is not routinely performed and cardiotoxicity patient care is based on the onco-hematologist criteria).\n\nThe primary endpoint is to determine whether this primary prevention englobing cardiovascular monitoring plus intensive multidisciplinary management is superior to the current clinical practice in reducing all cause mortality.\n\nOther secondary objectives of the study are to analyze the impact of this intensive cardiovascular monitoring strategy on the incidence of cardiovascular mortality, oncological mortality, hospitalization and\u002For urgent care due to cardiovascular complications, hospitalization and\u002For urgent oncological care due to cancer complications, tumor progression and cost-effectiveness analysis.\n\nA total of 514 patients ≥ 65 years old diagnosed with any of the following onco-hematological cancers, colon, breast, lymphoma, chronic lymphoma leukemia, chronic myeloid leukemia or myeloma, undergoing standardized anti-tumoral treatment, will be recruited.\n\nThe incidence of primary and secondary outcomes will be measured at 2 and 5 years",[276,277,278,279],"Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)","Elderly","Antineoplastic Agents","Cardiotoxicity",[279,277,281,282,283,284,285,286,287,288,289,290],"Antineoplastic agents","Cardiovascular monitoring","Cardioprotection","Cardio-oncology","Chemically-Induced Disorders","Radiation Injuries","Drug-Related Side Effects and Adverse Reactions.","Primary prevention","Secondary prevention.","Mortality","2025-03-18",{"date":293,"type":294},"2025-03-21","ACTUAL",{"date":296,"type":294},"2019-08-02",{"date":298,"type":270},"2025-11-30",{"name":5,"class":6},14]