[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582316":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":36,"locations":24,"responsibleParty":42,"collaborators":24,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":24,"eligibilityCriteria":51,"healthyVolunteers":48,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":24,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":24,"overallStatus":67,"whyStopped":24,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":24},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"VOCO Fissurit","ACTIVE_COMPARATOR","Sealants are restorative dental materials applied to the pit-and-fissure surfaces of teeth. Upon application, the sealant material infiltrates the pits and fissures, subsequently polymerizing to form a hardened layer. This layer serves as a physical barrier, effectively preventing or restricting the penetration of bacteria and nutrients, thereby mitigating the risk of caries formation in these susceptible areas. Pit and fissure sealants: Evidence-based recommendations support the use of sealants for the prevention and management of pit and fissure caries. Sealants are effective and should be applied to the occlusal surfaces of first and second permanent molars. Additionally, non-operative cleaning of fissures with a toothbrush or bristle brush is recommended.",[13],"Other: VOCO Fissurit",{"label":15,"type":16,"description":17,"interventionNames":18},"Silver Diamine Fluoride (SDF)","EXPERIMENTAL","Advantage Arrest Silver Diamine Fluoride 38%-SDF is an anti-microbial and remineralizing liquid clinically applied to control and arrest active dental caries and stop hypersensitivity. It is a safe, painless alternative to traditional cavity drilling procedures with the Power of Silver and Fluoride. Silver acts as an antimicrobial agent that simultaneously strengthens the dentin. Fluoride is the active ingredient that puts a stop to tooth decay by remineralising and helps prevent additional decay from appearing. It is also helpful to get relief from hypersensitivity.\n\nThe only common side effect is SDF causes black staining, but SDF\u002FKI and NSF may reduce this staining effect. SDF can also stain surfaces that it comes into contact with when being applied, such as clothing or nearby tissues in the mouth. For best results, SDF should be reapplied every 3, 6, or 12 months, If the cavity still progresses.",[19],"Other: Silver Diamine Fluoride (SDF)",[21,25],{"type":6,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"Silver Diamine Fluoride has been used extensively around the globe for decades. Advantage Arrest silver diamine fluoride 38% will change how you offer your patients the protection they deserve.\n\nAdvantage Arrest:\n\nProvides immediate relief from dentinal hypersensitivity Kills pathogenic organisms Hardens softened dentin making it more acid and abrasion resistant Does not stain sound dentin or enamel Can provide important clinical feedback due to its potential to stain visible or hidden lesions Silver diamine fluoride 38% is indicated for the treatment of dentinal hypersensitivity.",[15],null,{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Transparent Light-cured pits and fissure sealant, with high stability and good adhesion to enamel",[9],[29,33],{"name":30,"affiliation":31,"role":32},"Omaima Safwat Hamza, Professor","Professor of Esthetic and Conservative Dentistry, Faculty of Dentistry, Cairo University in Egypt.","STUDY_DIRECTOR",{"name":34,"affiliation":35,"role":32},"Dina Mounir El-Kadi","Lecturer of Esthetic and Conservative Dentistry, Faculty of Dentistry, Cairo University.",[37],{"name":38,"role":39,"phone":40,"phoneExt":24,"email":41},"Amr Abir Atmaz Alsibaee, Master's student","CONTACT","(+20)1093034394","Amr.alsibaee@dentistry.cu.edu.eg",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Amr Abir Atmaz Alsibaee","Dr.Amr Abir Atmaz Alsibaee","100582316","caries-arrest-using-silver-diamine-fluoride-versus-fissure-sealant-in-occlusal-dental-carious-lesions-randomized-controlled-trial-100582316",false,"NCT06861725","CARIES ARREST USING SILVER DIAMINE FLUORIDE VERSUS FISSURE SEALANT in OCCLUSAL DENTAL CARIOUS LESIONS: RANDOMIZED CONTROLLED TRIAL","Inclusion Criteria:\n\n1. Patient consulting in the outpatient clinic.\n2. Patients with enamel caries in molars permanent teeth, according to ICDAS 1 and 2.\n3. Provide informed consent.\n4. Co-operative patients approving to participate in the trial.\n5. Patient age (20-45 years old).\n\nExclusion Criteria:\n\n1. Tooth mobility.\n2. Signs of pulpal infection.\n3. Severe medical conditions that would not allow management in the clinic.\n4. Hereditary developmental defects, such as amelogenesis imperfecta or dentinogenesis imperfecta.\n5. Known allergies or sensitivities to dental materials, including SDF and fissure sealant.\n6. Inability to return for recall visits.\n7. Patients with bad oral hygiene\n8. Refuse to participate in the study.","ALL","20 Years","45 Years",{"count":56,"type":57},76,"ESTIMATED","INTERVENTIONAL",[60],"NA","The goal of this randomized clinical trial is to evaluate if Silver Diamine Fluoride (SDF) is a more conservative and effective treatment in preventing the progression of mild occlusal caries compared to fissure sealant in patients aged 20-45 years with incipient molar caries. The main question it aims to answer is:\n\nIs SDF more effective in arresting caries progression than fissure sealant? Does SDF prevent the formation of new caries compared to fissure sealant? Researchers will compare SDF treatment to fissure sealant application to see if SDF results in better caries arrest and fewer new carious lesions.\n\nParticipants will:\n\nBe randomly assigned to receive either SDF or fissure sealant. Have follow-up assessments at 1, 3, 6, and 12 months for caries progression, arrest, and new caries formation.\n\nUndergo clinical evaluations using visual and tactile examinations to assess caries arrest and progression and using DIAGNOdent laser fluorescence system .",[63,64,65,66],"Dental Caries","Caries Arrested","Silver Diamine Fluoride","Fissure Sealant","NOT_YET_RECRUITING","2025-03-01",{"date":70,"type":71},"2025-03-06","ACTUAL",{"date":73,"type":57},"2025-04-01",{"date":75,"type":57},"2026-05-01",{"name":5,"class":6}]