[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578650":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":57,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":62,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":10,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Tanta University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"GA induced hypotension in geriatrics",null,"Postinduction hypotension will be defined as either\n\n* A 30% drop in SBP or 20% drop in MAP from baseline, or an absolute SBP of less than 90 mm Hg and MAP of less than 65 mm Hg within three minutes of general anaesthesia induction, every minute until 15 min after endotracheal intubation and before the start of any surgical manipulations.\n* Since endotracheal intubation and direct laryngoscopy can generate sympathetic activation, which will change blood pressure, we decided to start haemodynamic monitoring three minutes post endotracheal intubation.\n* If the MAP was less than 65 mmHg, a 250 ml crystalloid bolus will be administered and repeated as necessary.\n* If hypotension persist after IV fluid bolus, ephedrine will be given by three milligrams.\n\nAt the end of surgery.",[13,14],"Diagnostic Test: Carotid Artery Corrected Flow Time measurement","Diagnostic Test: Inferior vena cava collapsibility index",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Carotid Artery Corrected Flow Time measurement","* The cFT is defined as the time between the onset of systolic flow until closure of the aortic valve corrected for the HR and has been found to correlate with the intravascular volume.\n* carotid ultrasound imaging will be performed 10 minutes before induction of general anesthesia in the preoperative holding area.\n* Ultrasound measurements will be performed under a vascular setting with a 6.0 to 13.0MHz linear array transducer\n* The right common carotid artery cFT will be measured in supine position with their heads tilted 30° to the left\n* After that, a pulse wave Doppler will be chosen, and the sampling frame will be positioned at an angle of less than 60° in the region of the carotid artery with the best color flow to acquire the blood flow spectrum.",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Inferior vena cava collapsibility index","* The IVC will be examined while the patient has been spontaneously, quietly breathing and lying in the supine position for at least 5 min before assessment.\n* A two-dimensional image of the IVC as it entered the right atrium will be obtained through the paramedian long-axis view via a subcostal approach using a curvilinear phased array probe (2-5 MHz)\n* Then, using M-mode imaging produced at a medium sweep speed, changes in IVC diameter with breathing will be evaluated 2 to 3 cm distal to the right atrium.\n* During the same respiratory cycle, measurements will be made of the IVC's greatest expiratory diameter (dIVC expiration) and lowest inspiratory diameter (dIVC inspiration). The formula IVCCI = (dIVC expiration - dIVC inspiration) × 100\u002FdIVC expiration will be used to determine IVCCI as a percentage. (12)\n* IVCCI will be assessed by the same trained anesthesiologist who was blinded to postin duction hemodynamic measurements.",[9],[26],{"name":27,"affiliation":28,"role":29},"tarek Mostafa","tanta university, faculty of medicine","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"tarek AH Mostafa","CONTACT","01003591332","dr.tarek311@yahoo.com",{"name":37,"role":33,"phone":10,"phoneExt":10,"email":38},"sameh Ahmed","samehabdelkhalik1982@gmail.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Faculty of medicine, Tanta university","RECRUITING","Tanta","El Gharbyia","31111","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.00192,30.78847,{"lat":52,"lon":51},[55],{"name":27,"role":33,"phone":56,"phoneExt":10,"email":35},"020403332033",{"type":29,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"tarek abdel hay mostafa","principle investigator","100578650","carotid-artery-corrected-flow-time-and-inferior-vena-cava-collapsibility-index-for-prediction-of-hypotension-after-induction-of-general-anesthesia-in-geriatric-patients-undergoing-elective-surgery-100578650",false,"NCT06814054","Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery","Inclusion Criteria:\n\n* American Society of Anaesthesiologists Physical Status I to Ⅱ\n* receiving general anesthesia for elective surgery\n* fasted for at least 6 to 8 hours were recruited in this study\n\nExclusion Criteria:\n\n* • patients who refused to participate in the study\n\n  * American Society of Anaesthesiologists Physical Status Ⅲ or Ⅳ\n  * Patients with a history of peripheral arterial diseases or atherosclerosis\n  * Patients with body mass index of greater than 30 kg\u002Fm2\n  * Patients with arrhythmia or cardiomyopathy\n  * Chronic obstructive pulmonary disease (COPD)\n  * baseline systolic arterial pressure (SAP) ≥ 180 mmHg or \\\u003C 90mmHg\n  * Any episode of desaturation or difficult intubation during general anasethia induction","ALL","65 Years",{"count":69,"type":70},189,"ESTIMATED","OBSERVATIONAL","In this observational study, we will assess cFT by Carotid ultrasound and IVC collapsibility index for prediction of hypotension after induction of general anesthesia in geriatric patients undergoing elective surgery.",[74,75,76,77],"Geriatrics","Hypotension on Induction","General Anesthetic Drug Adverse Reaction","Elective Surgery","2025-06-29",{"date":80,"type":81},"2025-07-01","ACTUAL",{"date":83,"type":81},"2025-03-01",{"date":85,"type":70},"2026-05",{"name":5,"class":6},1]