[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641563":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":57,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":78,"whyStopped":25,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual Care","ACTIVE_COMPARATOR","Patients will receive standard of care support",[13],"Other: Standard of Care",{"label":15,"type":16,"description":17,"interventionNames":18},"Structured Outreach","EXPERIMENTAL","Patients and relatives will receive outreach in the form of direct or indirect contact",[19],"Other: Cascade testing",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Cascade testing","Patient relatives will be contacted either directly or indirectly per patient preference:\n\nThe indirect contact method provides patients with structured Mayo approved educational materials to support the index patient in accurate and consistent communication with relatives. Relatives have the option to contact the study team for cascade genetic testing.\n\nThe direct contact method provides patients with a letter inviting relatives to contact the study team. After contact, relatives are offered educational materials and the opportunity for cascade genetic testing.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Standard of Care","No structured outreach is provided to patient or family members. Relatives may have their primary care provider refer them to genetic counseling services for cascade testing coordination.",[9],[31],{"name":32,"affiliation":5,"role":33},"Elisa J. Houwink, MD, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Family Medicine Research Study Coordinators","CONTACT","507-422-6823","RSTFMSC@mayo.edu",[41],{"facility":42,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Mayo Clinic in Rochester","Rochester","Minnesota","55905","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-92.4699,44.02163,{"lat":52,"lon":51},[55,56],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Isa J. Houwink","Principal Investigator","100641563","cascade-testing-in-identifying-at-risk-family-members-of-individuals-with-familial-hypercholesterolemia-fh-in-pcp-100641563",false,"NCT07653555","Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP","A Cluster Randomized Controlled Trial To Evaluate The Efficacy Of Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP","Inclusion Criteria:\n\nIndex Patients:\n\n* Age ≥ 18 years.\n* Confirmed FH diagnosis using Dutch Lipid Clinic Network criteria \\*or\\* genetic confirmation.\n* Identified through REP or Tapestry databases.\n* Able and willing to provide informed consent.\n* At least one eligible first- or second-degree relative.\n* Access to and active use of email (computer literacy requirement).\n\nRelatives:\n\n* First- or second-degree relative of an enrolled index patient.\n* Age ≥ 1 year (minors require parental consent + assent).\n* Willing to participate and able to complete electronic consent (guardian-assisted if minor).\n* Access to and active use of email (guardian).\n\nExclusion Criteria:\n\nIndex Patients:\n\n* No confirmed FH diagnosis.\n* Insufficient clinical follow-up (\\\u003C5 years).\n* No identifiable or contactable relatives.\n* Prior participation in structured cascade testing.\n* Severe cognitive impairment preventing informed consent.\n\nRelatives:\n\n* Prior participation in structured cascade testing.\n* Severe cognitive impairment preventing informed consent.","ALL","1 Year",{"count":70,"type":71},480,"ESTIMATED","INTERVENTIONAL",[74],"NA","The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).",[77],"Familial Hypercholesterolemia","NOT_YET_RECRUITING","2026-06-12",{"date":81,"type":82},"2026-06-17","ACTUAL",{"date":84,"type":71},"2026-06-20",{"date":86,"type":71},"2029-09-20",{"name":5,"class":6},1]