[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622231":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":24,"centralContacts":38,"locations":47,"responsibleParty":92,"collaborators":10,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":10,"eligibilityCriteria":99,"healthyVolunteers":96,"sex":100,"minAge":101,"maxAge":10,"enrollmentInfo":102,"targetDuration":10,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":117,"whyStopped":10,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Atrial Fibrillation Network","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Usual Care",null,[12],"Other: Usual Care",{"label":14,"type":6,"description":10,"interventionNames":15},"Pulmonary Vein Isolation",[16],"Other: Pulmonary Vein Isolation",[18,21],{"type":6,"name":9,"description":19,"armGroupLabels":20,"otherNames":10},"Usual care will consist of optimal AF and heart failure therapy based on guideline recommendations and local protocols and usage. Individual treatment decisions will be taken by the site teams, considering the approved instruction for use (IFU) of medical devices and summary of product characteristics (SmPC) of all approved medications in patients with AF. The choice of therapies and medications follows routine care in line with medical guidelines and local policies at the discretion of the treating physician and should be based on the individual medical status of each study patient.",[9],{"type":6,"name":14,"description":22,"armGroupLabels":23,"otherNames":10},"Patients randomised to AF ablation will undergo pulmonary vein isolation using a safe and effective technology within 30 days after randomisation.",[14],[25,29,32,35],{"name":26,"affiliation":27,"role":28},"Lars Eckardt, MD","University Hospital Münster","STUDY_DIRECTOR",{"name":30,"affiliation":31,"role":28},"Daniel Steven, MD","University Hospital Cologne",{"name":33,"affiliation":34,"role":28},"Reza Wakili, MD","University Heart and Vascular Center Frankfurt",{"name":36,"affiliation":37,"role":28},"Stephan Willems, MD","Asklepios Hospital St. Georg",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Vincent Beuger, PhD","CONTACT","+49 251 276001 64","caba-mitra@af-net.eu",{"name":45,"role":41,"phone":46,"phoneExt":10,"email":43},"Sabine Jürgensmeyer, PhD","+4925127600167",[48,61,71,81],{"facility":31,"status":10,"city":49,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Cologne","Germany","DE",{"type":53,"coordinates":54},"Point",[55,56],6.95,50.93333,{"lat":56,"lon":55},[59],{"name":30,"role":41,"phone":60,"phoneExt":10,"email":43},"+ 49 221 478 32396",{"facility":34,"status":10,"city":62,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Frankfurt",{"type":53,"coordinates":64},[65,66],10.53333,49.68333,{"lat":66,"lon":65},[69],{"name":33,"role":41,"phone":70,"phoneExt":10,"email":43},"+49 69 6301-5789",{"facility":37,"status":10,"city":72,"state":10,"zip":10,"country":50,"countryCode":51,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Hamburg",{"type":53,"coordinates":74},[75,76],9.99302,53.55073,{"lat":76,"lon":75},[79],{"name":36,"role":41,"phone":80,"phoneExt":10,"email":43},"+49 40 181885-2050\u002F2309",{"facility":27,"status":10,"city":82,"state":10,"zip":83,"country":50,"countryCode":51,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Münster","48149",{"type":53,"coordinates":85},[86,87],7.62571,51.96236,{"lat":87,"lon":86},[90],{"name":26,"role":41,"phone":91,"phoneExt":10,"email":43},"+49 251 834 7637",{"type":93,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622231","catheter-ablation-for-af-in-patients-with-severe-mitral-regurgitation-after-successful-transcatheter-mitral-valve-repair-100622231",false,"NCT07380932","Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair","Inclusion Criteria:\n\n* Patients with documented atrial fibrillation (AF).\n* Transcatheter edge-to-edge mitral-valve repair (TEER) for severe functional mitral valve regurgitation (MR) with successful result (less than moderate MR, gradient \\\u003C 5 mmHg) performed within a period of minimum of 30 days and a maximum of 6 months. Moderate residual MR is eligible if no further mitral valve intervention or surgery is planned and patient is stable for \\> 3 months.\n* Provision of signed informed consent.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Patient not suitable for AF ablation\n* Previous ablation procedure for AF\n* Acute coronary syndrome, cardiac surgery, angioplasty, or cerebrovascular accident within 2 months prior to enrolment\n* Untreated hypothyroidism or hyperthyroidism requiring therapy\n* Enrolment in another randomised study\n* Indication for cardiac resynchronization therapy\n* Current pregnancy, breastfeeding, or women not using reliable contraceptive measures during fertility age\n* Mental or physical inability to participate in the study\n* Planned cardiovascular intervention or operation\n* Life expectancy ≤ 12 month","ALL","18 Years",{"count":103,"type":104},956,"ESTIMATED","INTERVENTIONAL",[107],"NA","CABA-MiTRA-AFNET12 is a non-commercial, parallel-group, prospective, randomised, open, blinded endpoint assessment (PROBE), multi-centre, therapy strategy trial. The trial investigates patients with severe mitral valve regurgitation who have undergone transcatheter edge-to-edge mitral valve repair (M-TEER) and have concomitant atrial fibrillation (AF). The objective is to assess whether catheter ablation of AF is superior to standard-of-care treatment in patients after TEER in reduction of major adverse cardiovascular and cerebrovascular events (MACCE).",[110,111],"Atrial Fibrillation (AF)","Mitral Valve (MV) Regurgitation",[113,114,115,116],"Atrial fibrillation","Mitral valve regurgitation","Mitral valve repair","Catheter ablation","NOT_YET_RECRUITING","2026-01-23",{"date":120,"type":121},"2026-02-02","ACTUAL",{"date":123,"type":104},"2026-07-01",{"date":125,"type":104},"2032-01-31",{"name":5,"class":6},4]