[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525828":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":37,"centralContacts":41,"locations":50,"responsibleParty":67,"collaborators":32,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":32,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":52,"whyStopped":32,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Florida State University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Steep-tRAS,","EXPERIMENTAL","Transcranial random aperiodic stimulation (tRAS) delivers 1 milliampere (mA) zero-to-peak amplitude at the target electrodes and 2 mA at the return electrode. The condition of interest, steep-tRAS, mimics a steep slope of the aperiodic signal characterized by greater low relative to high frequency power. Participants receive all three types of stimulation in an intermixed, balanced, and randomized order. There are twelve total blocks of approximately five minutes of stimulation with four blocks of each type of stimulation.",[13],"Device: Steep-tRAS",{"label":15,"type":16,"description":17,"interventionNames":18},"Flat-tRAS","ACTIVE_COMPARATOR","Transcranial random aperiodic stimulation (tRAS) delivers 1 milliampere (mA) zero-to-peak amplitude at the target electrodes and 2 mA at the return electrode. The active control, flat-tRAS, mimics a flat slope aperiodic signal characterized by greater high relative to low frequency power. Participants receive all three types of stimulation in an intermixed, balanced, and randomized order. There are twelve total blocks of approximately five minutes of stimulation with four blocks of each type of stimulation.",[19],"Device: Flat-tRAS",{"label":21,"type":22,"description":23,"interventionNames":24},"Sham-tRAS","SHAM_COMPARATOR","Transcranial random aperiodic stimulation (tRAS) delivers 1 milliampere (mA) zero-to-peak amplitude at the target electrodes and 2 mA at the return electrode. For active sham stimulation, steep-tRAS or flat-tRAS is delivered for only 15 seconds at the beginning and end of the block. This mimics the skin sensations (e.g., itching, burning, tingling) to assist with blinding the participant. Participants receive all three types of stimulation in an intermixed, balanced, and randomized order. There are twelve total blocks of approximately five minutes of stimulation with four blocks of each type of stimulation.",[25],"Device: Sham-tRAS",[27,33,35],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Steep-tRAS","Stimulation will be delivered via the NeuroConn Direct Current Stimulator Plus Multiple Channels, an investigational electrical non-invasive brain stimulation device that is being used for foundational neuroscience and translational research.",[9],null,{"type":28,"name":15,"description":30,"armGroupLabels":34,"otherNames":32},[15],{"type":28,"name":21,"description":30,"armGroupLabels":36,"otherNames":32},[21],[38],{"name":39,"affiliation":5,"role":40},"Justin Riddle, PhD","PRINCIPAL_INVESTIGATOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":32,"email":45},"CONTACT","850-645-2389","jriddle@fsu.edu",{"name":47,"role":43,"phone":48,"phoneExt":32,"email":49},"Lauren Jackson, BS","850-644-9869","lauren.jackson@fsu.edu",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"RECRUITING","Tallahassee","Florida","32306","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-84.28073,30.43826,{"lat":62,"lon":61},[65,66],{"name":39,"role":43,"phone":44,"phoneExt":32,"email":45},{"name":39,"role":40,"phone":32,"phoneExt":32,"email":32},{"type":40,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Justin Riddle","Principal Investigator","100525828","causal-role-of-the-aperiodic-signal-for-working-memory-100525828",false,"NCT06126809","Causal Role of the Aperiodic Signal for Working Memory","TRAS","Inclusion Criteria:\n\n* Between the ages of 18 and 35\n* Able to provide informed consent\n* Normal or corrected-to-normal vision\n* Willing to comply with all study procedures and be available for the duration of the study\n* Ability to speak, read and understand English without a translator\n* Not color-blind\n\nExclusion Criteria:\n\n* ADHD\u002FADD (currently under treatment)\n* Neurological disorder and conditions\n* Medical or neurological illness or treatment for a medical disorder that could interfere with study participation, e.g., unstable cardiac disease, HIV\u002FAIDS, malignancy, liver or renal impairment\n* Prior brain surgery\n* Any brain devices\u002Fimplants, including cochlear implants and aneurysm clips\n* History of traumatic brain injury\n* (For females) Pregnant\n* Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study\n* Current use of medications know to produce specific EEG activity known to disrupt interpretations of the findings including but not limited to: benzodiazepines, antipsychotics, antiepileptics and central nervous system stimulants",true,"ALL","18 Years","35 Years",{"count":82,"type":83},30,"ESTIMATED","INTERVENTIONAL",[86],"NA","Working memory (WM) is the ability to hold relevant information in mind in the absence of sensory input. The capacity for WM is a foundation for cognitive control and higher cognitive function more broadly. Previous research demonstrated that during the delay period of WM tasks, oscillatory electrical activity in the prefrontal cortex in the theta-frequency band (4-8 Hz) increased in amplitude. However, other groups found that the slope of the aperiodic signal in the brain was positively correlated with individual differences in WM capacity. Since low-frequency power and a steeper slope of the aperiodic signal are confounded in many analyses, it is not clear whether the slope of the aperiodic signal or the amplitude of low-frequency oscillations underlie WM capacity. With many studies investigating the causal role of theta oscillations in WM, the purpose of this project is to investigate the role of the aperiodic signal in WM performance.",[89],"Executive Dysfunction",[91,92,93,94],"cognitive control","working memory","electroencephalography","transcranial electrical stimulation","2026-01-09",{"date":97,"type":98},"2026-01-12","ACTUAL",{"date":100,"type":98},"2024-03-25",{"date":102,"type":83},"2026-12",{"name":5,"class":6},1]