[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595789":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":34,"locations":44,"responsibleParty":65,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":18,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":18,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Istanbul Nisantasi University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CBT Intervention Group","EXPERIMENTAL","Participants diagnosed with restrictive-type anorexia nervosa will receive 12 weekly individual Cognitive-Behavioral Therapy (CBT) sessions. Each session will last approximately 60 minutes and be delivered by a trained therapist. The CBT protocol targets body image distortion, cognitive restructuring of maladaptive beliefs, exposure to food-related stimuli, emotional regulation strategies, and behavioral experiments to reduce avoidance. Pre- and post-treatment neurophysiological (EEG), physiological (GSR), and attentional (eye-tracking) assessments will be conducted.",[13],"Behavioral: Cognitive-Behavioral Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Waitlist Control Group","NO_INTERVENTION","Participants diagnosed with restrictive-type anorexia nervosa will be placed on a waitlist and will not receive any structured psychological intervention during the 12-week study period. They will complete the same neurophysiological (EEG), physiological (GSR), and attentional (eye-tracking) assessments at baseline and at the 12-week follow-up.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Cognitive-Behavioral Therapy","Manualized 12-week CBT protocol focused on reducing body image disturbance, distorted beliefs about food and appearance, and avoidance behaviors in individuals with anorexia nervosa. The intervention incorporates psychoeducation, cognitive restructuring, emotional regulation, food exposure, and body image work.",[9],[26,30],{"name":27,"affiliation":28,"role":29},"Gökben Hızlı Sayar, Professor","Üsküdar University","STUDY_CHAIR",{"name":31,"affiliation":32,"role":33},"Eda Yılmazer, Phd","Beykoz University","STUDY_DIRECTOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":18,"email":39},"Metin Çınaroğlu, Phd","CONTACT","00905324732070","metincinaroglu@gmail.com",{"name":41,"role":37,"phone":42,"phoneExt":18,"email":43},"Selami Varol Ülker, Phd","00905364360941","selamivarol.ulker@uskudar.edu.tr",[45],{"facility":46,"status":47,"city":48,"state":18,"zip":18,"country":49,"countryCode":18,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Üsküdar University Neuro Marketing Lab.","RECRUITING","Istanbul","Turkey (Türkiye)",{"type":51,"coordinates":52},"Point",[53,54],28.94966,41.01384,{"lat":54,"lon":53},[57,59,62,64],{"name":58,"role":37,"phone":42,"phoneExt":18,"email":43},"Selami Varol Ülker, phd",{"name":27,"role":37,"phone":60,"phoneExt":18,"email":61},"00905302441316","gokben.hizlisayar@uskudar.edu.tr",{"name":36,"role":63,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"name":31,"role":63,"phone":18,"phoneExt":18,"email":18},{"type":63,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Metin Çınaroğlu","Assistant Professor",[69,71],{"name":70,"class":6},"Uskudar University",{"name":32,"class":6},"100595789","cbt-effects-on-neural-physiological-and-attentional-responses-in-anorexia-nervosa-100595789",false,"NCT07037017","CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa","Neurophysiological Effects of Cognitive-Behavioral Therapy in Anorexia Nervosa: A Pre-Post EEG, GSR, and Eye-Tracking Study","Inclusion Criteria:\n\n* Female participants aged 18 to 35\n* Meeting DSM-5 diagnostic criteria for restrictive-type anorexia nervosa\n* Body Mass Index (BMI) between 15.0 and 18.5\n* Medically stable to participate in psychological and neurophysiological assessments\n* Willingness to participate in weekly therapy sessions (for the CBT group) and to complete pre- and post-assessments\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Current or past diagnosis of bulimia nervosa, binge-eating disorder, or other eating disorders\n* Presence of comorbid severe psychiatric disorders (e.g., psychosis, bipolar disorder, substance use disorder)\n* History of neurological illness or traumatic brain injury\n* Use of psychotropic medication within the last 6 weeks\n* Prior participation in structured Cognitive-Behavioral Therapy for an eating disorder\n* Pregnancy\n* Visual or neurological impairments that would prevent accurate EEG, GSR, or eye-tracking recordings","FEMALE","18 Years","35 Years",{"count":83,"type":84},60,"ESTIMATED","INTERVENTIONAL",[87],"NA","This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiological and attentional mechanisms related to body image disturbance and food-related anxiety in AN, contributing to biomarker-informed psychotherapy approaches.",[90],"Eating Disorders (Excluding Anorexia Nervosa)",[92,93,94,95,96],"Cognitive Behavioral Therapy (CBT)","EEG","Eye-Tracking","Galvanic Skin Response (GSR)","Body Image","2025-06-17",{"date":99,"type":100},"2025-06-25","ACTUAL",{"date":102,"type":100},"2025-05-15",{"date":104,"type":84},"2025-10-15",{"name":5,"class":6},1]