[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550797":3},{"organization":4,"armGroups":7,"interventions":36,"overallOfficials":51,"centralContacts":56,"locations":66,"responsibleParty":141,"collaborators":42,"id":143,"slug":144,"hasResults":145,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":145,"sex":151,"minAge":152,"maxAge":42,"enrollmentInfo":153,"targetDuration":42,"studyType":156,"phases":157,"briefSummary":159,"conditions":160,"keywords":42,"overallStatus":69,"whyStopped":42,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},{"fullName":5,"class":6},"Institut Pasteur","INDUSTRY",[8,16,20,23,27,30,33],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral lichen planus erosive","EXPERIMENTAL","Human biological samples :\n\n* blood samples collection at visit 1 and 2 (6 month after first visit)\n* brushing on skin or mucous membrane lesions at visit 1\n* skin or mucous membrane biopsy at visit 1 and 2",[13,14,15],"Other: Blood samples collection","Other: Skin or mucous membrane brushing","Other: Skin or mucous membrane biopsy",{"label":17,"type":10,"description":18,"interventionNames":19},"mucosal pemphigoid with oral lesions","Human biological samples :\n\n* blood samples collection at visit 1\n* brushing on skin or mucous membrane lesions at visit 1",[13,14],{"label":21,"type":10,"description":18,"interventionNames":22},"lichen planus with scalp involvement",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Pseudopelade of Brocq","Human biological samples :\n\n* blood samples collection at visit 1\n* brushing on skin or mucous membrane lesions at visit 1\n* skin or mucous membrane biopsy at visit 1",[13,14,15],{"label":28,"type":10,"description":18,"interventionNames":29},"lichen planus with nail involvement",[13,14],{"label":31,"type":10,"description":18,"interventionNames":32},"psoriasis and specific nail involvement",[13,14],{"label":34,"type":10,"description":18,"interventionNames":35},"Lichenoid graft-versus-host disease",[13,14],[37,43,47],{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"OTHER","Blood samples collection","50 mL blood sample",[34,9,24,28,21,17,31],null,{"type":38,"name":44,"description":45,"armGroupLabels":46,"otherNames":42},"Skin or mucous membrane brushing","brushing on skin or mucous membrane lesions",[34,9,24,28,21,17,31],{"type":38,"name":48,"description":49,"armGroupLabels":50,"otherNames":42},"Skin or mucous membrane biopsy","6 mm biopsy",[9,24],[52],{"name":53,"affiliation":54,"role":55},"Manuelle Vigiuer","CHU Reims Service de Dermatologie Avenue du Général Koenig 51092 Reims","PRINCIPAL_INVESTIGATOR",[57,62],{"name":58,"role":59,"phone":60,"phoneExt":42,"email":61},"Marie-Lise Gougeon","CONTACT","1 40 66 97 87","marie-lise.gougeon@pasteur.fr",{"name":63,"role":59,"phone":64,"phoneExt":42,"email":65},"Sandrine Fernandes Pellerin","1 45 68 81 79","sandrine.fernandes-pellerin@pasteur.fr",[67,83,94,108,118,130],{"facility":68,"status":69,"city":70,"state":42,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"CHU de Besançon","RECRUITING","Besançon","25030","France","FR",{"type":75,"coordinates":76},"Point",[77,78],6.01815,47.24878,{"lat":78,"lon":77},[81],{"name":82,"role":59,"phone":42,"phoneExt":42,"email":42},"François Aubin, Pr",{"facility":84,"status":69,"city":85,"state":42,"zip":42,"country":72,"countryCode":73,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"CHU Paris Seine-Saint-Denis- Hôpital Avicenne","Bobigny",{"type":75,"coordinates":87},[88,89],2.45012,48.90982,{"lat":89,"lon":88},[92],{"name":93,"role":59,"phone":42,"phoneExt":42,"email":42},"Frédéric Caux, Pr",{"facility":95,"status":69,"city":96,"state":42,"zip":97,"country":72,"countryCode":73,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"Centre Medical de l'Institut Pasteur","Paris","75015",{"type":75,"coordinates":99},[100,101],2.3488,48.85341,{"lat":101,"lon":100},[104],{"name":105,"role":59,"phone":106,"phoneExt":42,"email":107},"Fabien Taieb, Dr","+33145688088","fabien.taieb@pasteur.fr",{"facility":109,"status":69,"city":96,"state":42,"zip":42,"country":72,"countryCode":73,"cosmosGeoPoint":110,"geoPoint":112,"contacts":113},"Hôpital Saint-Louis",{"type":75,"coordinates":111},[100,101],{"lat":101,"lon":100},[114,116],{"name":115,"role":59,"phone":42,"phoneExt":42,"email":42},"Hervé Bachelez, Pr",{"name":117,"role":55,"phone":42,"phoneExt":42,"email":42},"Jean-David Bouaziz",{"facility":119,"status":69,"city":120,"state":42,"zip":121,"country":72,"countryCode":73,"cosmosGeoPoint":122,"geoPoint":126,"contacts":127},"Hôpital Robert Debré, CHU de Reims","Reims","51092",{"type":75,"coordinates":123},[124,125],4.02853,49.26526,{"lat":125,"lon":124},[128],{"name":129,"role":59,"phone":42,"phoneExt":42,"email":42},"Manuelle Viguier, Pr",{"facility":131,"status":69,"city":132,"state":42,"zip":42,"country":72,"countryCode":73,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"CHU de Rouen","Rouen",{"type":75,"coordinates":134},[135,136],1.09932,49.44313,{"lat":136,"lon":135},[139],{"name":140,"role":59,"phone":42,"phoneExt":42,"email":42},"Pascal Joly, Pr",{"type":142,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100550797","cellular-and-molecular-biomarkers-in-patients-with-lichen-planus-100550797",false,"NCT06451744","Cellular and Molecular Biomarkers in Patients With Lichen Planus","Evaluation of the Clinical Specificity of Cellular and Molecular Biomarkers Identified in Patients With Lichen Planus","HELP","Inclusion Criteria:\n\n* Subject coming at the time of diagnosis of the disease before any systemic treatment, or at the time of a progressive episode of the disease, without systemic treatment or after cessation of immunomodulatory or immunosuppressive treatment\n* Ability to give their consent in writing\n* Must understand spoken and written French\n* Affiliated to the French social security or assimilated regimes\n\nExclusion Criteria:\n\n* Dermatosis exclusively localised in the skin folds or on the face (risk of scarring from biopsies)","ALL","18 Years",{"count":154,"type":155},70,"ESTIMATED","INTERVENTIONAL",[158],"NA","Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology, affecting the skin and mucous membranes, characterised by a CD8+ cytotoxic T-cell infiltrate, associated with epithelial cell death and disruption of the basement membrane zone. In previous work, T cell antigen receptor (TCR) repertoire studies were performed. In all patients tested, whether with erosive or non-erosive LP, unique nucleotide sequences, called clonotypes, have been identified. They appear during the process of TCR gene rearrangement. These clonotypes are specific for human papillomavirus (HPV) in blood and lesions, suggesting antigenic stimulation of these clonotypes by a viral epitope of HPV, which crosses with an epitope on keratinocytes. The diagnosis of LP is made on the basis of clinical and histological criteria, but in some patients and in some anatomical locations, the diagnosis is difficult to make and LP may be confused with other skin conditions.",[161],"Lichen Planus","2025-06-27",{"date":164,"type":165},"2025-07-01","ACTUAL",{"date":167,"type":165},"2023-11-01",{"date":169,"type":155},"2027-04-30",{"name":5,"class":6},6]