[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592449":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":38,"locations":44,"responsibleParty":63,"collaborators":31,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":31,"enrollmentInfo":77,"targetDuration":31,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":46,"whyStopped":31,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Active-tACS","EXPERIMENTAL","Patients receive an active tACS stimulation with 2-4 mA amplitude",[13],"Device: Active-tACS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-tACS","SHAM_COMPARATOR","Patients receive a tACS stimulation with 0 mA amplitude",[19],"Device: Sham-tACS",{"label":21,"type":22,"description":23,"interventionNames":24},"Unlocked-tACS","ACTIVE_COMPARATOR","Patients receive an active tACS stimulation with 2-4 mA amplitude but without phase alignment between tremor and tACS",[25],"Device: Unlocked-tACS",[27,32,35],{"type":28,"name":9,"description":29,"armGroupLabels":30,"otherNames":31},"DEVICE","30 seconds of closed-loop tACS at 2-4 mA, with 6 alternating phase alignments and 1-3 repetitions. Phase alignment is adjusted to the patient's tremor frequency and rhythm in real time. Administered using the neuroConn LOOPIT device and 2 electrodes placed on the cerebellum and jaw, with an area of 5x5 and 5x7 respectively. The stimulation begins with a 3-second ramp-up and ends with a 3-second ramp-down.",[9],null,{"type":28,"name":15,"description":33,"armGroupLabels":34,"otherNames":31},"30 seconds of tACS at 0 mA and 1-3 repetitions. Administered using the neuroConn LOOPIT device and 2 electrodes placed on the cerebellum and jaw, with an area of 5x5 and 5x7 respectively. The sham protocol begins with a 3-second ramp-up and ends with a 3-second ramp-down.",[15],{"type":28,"name":21,"description":36,"armGroupLabels":37,"otherNames":31},"30 seconds of open-loop tACS at 2-4 mA, with no phase alignments and 1-3 repetitions. Administered using the neuroConn LOOPIT device and 2 electrodes placed on the cerebellum and jaw, with an area of 5x5 and 5x7 respectively. The stimulation begins with a 3-second ramp-up and ends with a 3-second ramp-down.",[21],[39],{"name":40,"role":41,"phone":42,"phoneExt":31,"email":43},"Simone Zittel, Dr. med.","CONTACT","+49 40 7410 53770","s.zittel-dirks@uke.de",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Hamburg","Free and Hanseatic City of Hamburg","20246","Germany","DE",{"type":53,"coordinates":54},"Point",[55,56],9.99302,53.55073,{"lat":56,"lon":55},[59,60],{"name":40,"role":41,"phone":42,"phoneExt":31,"email":43},{"name":61,"role":62,"phone":31,"phoneExt":31,"email":31},"Fatemeh Sadeghi, Dr.","SUB_INVESTIGATOR",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Simone Zittel","Principal Investigator","100592449","cerebellar-transcranial-alternating-current-stimulation-tacs-to-modulate-parkinsons-disease-tremor-100592449",false,"NCT06993571","Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor","Closed-loop Phase-adaptive Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Activity in the Cerebello-thalamo-cortical Network to Reduce Parkinson's Disease Tremor","tACS_PD_TR","Inclusion Criteria:\n\n* Clinical diagnosis of Parkinson's disease based on UK Brain Bank criteria\n* Patient exhibiting moderate to severe hand tremor\n* Provision written informed consent by the patient\n\nExclusion Criteria:\n\n* History of other neurological disorders such as vascular malformations, ischemic or haemorrhagic stroke, cerebral neoplasia, epilepsy, or major psychiatric illness\n* Existence of heart pacemaker or metal implants in the body\n* Pregnancy","ALL","18 Years",{"count":78,"type":79},10,"ESTIMATED","INTERVENTIONAL",[82],"NA","Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage. Common treatments, such as dopaminergic therapy, can have limitations in efficacy. Recent advancements in non-invasive brain stimulation, specifically phase-adaptive transcranial alternating current stimulation (tACS), offer a promising approach to reduce PD tremor. In the current project, a newly developed closed-loop system delivers precisely synchronized cerebellar tACS by aligning stimulation with the intrinsic hand tremor signal. The study will assess the efficacy of this novel approach to reduce hand tremor in PD patients.",[85,86],"Parkinson's Disease (PD)","Tremor",[88,89,90,91,92,93,94],"Parkinson's disease","Hand tremor","Transcranial alternating current stimulation","Non-invasive brain stimulation","Closed-loop stimulation","Phase-adaptive stimulation","Tremor entrainment","2026-04-28",{"date":97,"type":98},"2026-05-04","ACTUAL",{"date":100,"type":98},"2025-04-16",{"date":102,"type":79},"2026-12-31",{"name":5,"class":6},1]