[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551218":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":41,"centralContacts":45,"locations":52,"responsibleParty":70,"collaborators":72,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":32,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":32,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":54,"whyStopped":32,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham Cerebellar Stimulation + Sham mPFC Stimulation Group","SHAM_COMPARATOR","This is the sham stimulation group. The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.",[13],"Device: Sham Intervention over cerebellum and mPFC",{"label":15,"type":16,"description":17,"interventionNames":18},"Cerebellar-mPFC Dual-Coil Paired-Pulse TMS Intervention Group","EXPERIMENTAL","The stimulation protocol involved delivering a pulse to the cerebellum first, followed by a pulse to the mPFC after a 6ms inter-stimulus interval (ISI). This 6ms interval was determined based on findings from our prior mechanistic study.",[19],"Device: Paired Associative Stimulation Targeting the Cerebellar-mPFC",{"label":21,"type":22,"description":23,"interventionNames":24},"Cerebellar Sham + Real mPFC Stimulation Group","ACTIVE_COMPARATOR","This group serves as the positive control group for single-site stimulation. Participants in this group will receive real stimulation over the medial prefrontal cortex combined with sham stimulation over the cerebellum. This design allows us to determine whether the therapeutic effects of paired cerebellum-medial prefrontal cortex stimulation are attributable to the paired stimulation protocol itself, rather than to the effect of single-target stimulation of the medial prefrontal cortex alone.",[25],"Device: Sham stimulation over the cerebellum + real stimulation over the medial prefrontal cortex",[27,33,37],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DEVICE","Paired Associative Stimulation Targeting the Cerebellar-mPFC","The protocol consisted of 180 pulse trains. Each train contained 5 pulse pairs delivered over 1 second, resulting in a stimulation frequency of 5 Hz. Within each pulse pair, the cerebellum was stimulated first, followed by the mPFC after a 6-ms inter-stimulus interval (ISI). In total, 900 pulse pairs were administered, and a complete intervention session lasted 11 minutes and 57 seconds.",[15],null,{"type":28,"name":34,"description":35,"armGroupLabels":36,"otherNames":32},"Sham Intervention over cerebellum and mPFC","The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.",[9],{"type":28,"name":38,"description":39,"armGroupLabels":40,"otherNames":32},"Sham stimulation over the cerebellum + real stimulation over the medial prefrontal cortex","Participants in this group will receive sham stimulation over the cerebellum (The coil will be placed vertically over the cerebellum) combined with real stimulation over the medial prefrontal cortex.",[21],[42],{"name":43,"affiliation":5,"role":44},"Min Zhao, PhD","STUDY_CHAIR",[46,50],{"name":43,"role":47,"phone":48,"phoneExt":32,"email":49},"CONTACT","64387250","drminzhao@gmail.com",{"name":51,"role":47,"phone":48,"phoneExt":32,"email":49},"64387250 Zhao, PhD",[53],{"facility":43,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Shanghai","Shanghai Municipality","200000","China","CN",{"type":61,"coordinates":62},"Point",[63,64],121.45806,31.22222,{"lat":64,"lon":63},[67,68],{"name":43,"role":47,"phone":48,"phoneExt":32,"email":49},{"name":43,"role":47,"phone":69,"phoneExt":32,"email":49},"18017311005",{"type":71,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[73,76,78,80,82],{"name":74,"class":75},"Chengdu Drug Rehabilitation Center","UNKNOWN",{"name":77,"class":75},"Sichuan Ziyang Compulsory Isolation Drug Rehabilitation Center",{"name":79,"class":75},"Mental Health Center, West China Hospital of Sichuan University, Chengdu",{"name":81,"class":75},"Wuhan Mental Health Center, The Ninth Clinical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan",{"name":83,"class":75},"HanYang Comoulsory Isolation Drug Rehabilitation Center, Wuhan","100551218","cerebellum-prefrontal-paired-pulse-stimulation-for-methamphetamine-use-disorder-100551218",false,"NCT06457230","Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder","Exploring the Mechanisms and Efficacy of Cerebellum-Medial Prefrontal Cortex-Based Paired-Pulse Repetitive Transcranial Magnetic Stimulation for Methamphetamine Use Disorder","Inclusion Criteria\n\nParticipants will be eligible for inclusion if they meet the following criteria:\n\n1. Methamphetamine is the primary substance of use, and the participant meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe methamphetamine use disorder;\n2. aged 18 to 60 years;\n3. normal or corrected-to-normal vision and hearing, and right-handedness;\n4. primary school education or above, with the ability to understand the questionnaires and behavioral task instructions.\n\nExclusion Criteria\n\nParticipants will be excluded if they meet any of the following criteria:\n\n1. presence of metal objects in the body, such as metal dentures, orthodontic braces, bone fixation plates, aneurysm clips, or other metallic implants;\n2. severe physical illness or chronic disease, including heart disease, severe hypertension, stroke, epilepsy, or history of head trauma;\n3. comorbid psychiatric disorders, such as bipolar disorder, schizophrenia, or severe depression;\n4. previous participation in transcranial magnetic stimulation- or electroencephalography-related studies;\n5. refusal to participate in the study, poor compliance, or any other contraindications to transcranial magnetic stimulation.",true,"MALE","18 Years","60 Years",{"count":96,"type":97},90,"ESTIMATED","INTERVENTIONAL",[100],"NA","To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.",[103],"Methamphetamine Use Disorder",[105,106,107,108,109],"Repetitive transcranial magnetic stimulation","Cerebellum","Methamphetamine","Cortico-Cortical Paired Associative Stimulation","medial prefrontal cortex","2026-06-21",{"date":112,"type":113},"2026-06-24","ACTUAL",{"date":115,"type":113},"2024-12-24",{"date":117,"type":97},"2026-09",{"name":5,"class":6},1]