[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550717":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":40,"locations":49,"responsibleParty":113,"collaborators":115,"id":129,"slug":130,"hasResults":131,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":131,"sex":137,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":34,"studyType":143,"phases":144,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":52,"whyStopped":34,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":162},{"fullName":5,"class":6},"Fundación de Investigación Biomédica - Hospital Universitario de La Princesa","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise intervention group (EG)","EXPERIMENTAL","Major Depressive Disorder patients will receive the exercise intervention for 12 weeks as an add-on to their usual treatment (antidepressant treatment prescribed by the attending specialist). They will gradually increase their levels of physical activity by daily walking and will conduct aerobic and muscle strength activities 2 days per week. The program will be supervised by a physical education and sports professional.",[13,14],"Other: Physical Exercise","Drug: Antidepressant medication (ADM)",{"label":16,"type":17,"description":18,"interventionNames":19},"Control group (CG)","ACTIVE_COMPARATOR","Major Depressive Disorder patients will only receive standard treatment (antidepressant treatment prescribed by the attending specialist) and will be instructed to not change their usual physical activity.",[14],[21,29],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Physical Exercise","Daily walking. Participants will be given an activity band to self-monitor the number of steps they walk each day during the 12-week intervention period. Each participant must reach a certain number of daily steps with a progressive goal adjusted to the number of steps from the previous week. The goal is set considering the superior number to the median of steps of the preceding week.\n\nWeekly combined exercise sessions (aerobic + strength exercise) 2 sessions of 60 minutes per week in a 12-week program. The exercise intervention will combine the use of elastic bands and the body weight. First, 5 minutes of warm-up; second, training circuit with low-intensity strength exercises alternating work and rest times using rhythmic music. Upper, lower and middle body exercises will alternate. The program will progress in intensity, work: rest ratio, and technical difficulty of the exercises. At the end of the main part, there will be a cool-down and stretching for 5 minutes.",[9],[26,27,28],"Therapeutic Exercise","physical activity","Exercise",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","Antidepressant medication (ADM)","Patients will receive their standard antidepressant treatment prescribed by their psychiatrist.",[16,9],null,[36],{"name":37,"affiliation":38,"role":39},"Pilar López García, PhD","Universidad Autonoma de Madrid","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":34,"email":45},"Javier Gómez Cumplido, PT, MSc","CONTACT","(+34) 633467602","javier.gomezc@uam.es",{"name":37,"role":43,"phone":47,"phoneExt":34,"email":48},"(+34) 91 497 54 48","p.lopez@uam.es",[50,68,80,90,100],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Hospital Universitario Príncipe de Asturias","RECRUITING","Alcalá de Henares","Madrid","28805","Spain","ES",{"type":59,"coordinates":60},"Point",[61,62],-3.35996,40.48205,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":34,"phoneExt":34,"email":67},"María Vicens Poveda","mvicenspoveda@gmail.com",{"facility":69,"status":52,"city":54,"state":54,"zip":70,"country":56,"countryCode":57,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Hospital Universitario de La Princesa","28006",{"type":59,"coordinates":72},[73,74],-3.70256,40.4165,{"lat":74,"lon":73},[77],{"name":78,"role":43,"phone":34,"phoneExt":34,"email":79},"Itziar Leal Leturia, PhD","Ileal.leturia@uam.es",{"facility":81,"status":52,"city":54,"state":54,"zip":82,"country":56,"countryCode":57,"cosmosGeoPoint":83,"geoPoint":85,"contacts":86},"Hospital Universitario Ramón y Cajal","28034",{"type":59,"coordinates":84},[73,74],{"lat":74,"lon":73},[87],{"name":88,"role":43,"phone":34,"phoneExt":34,"email":89},"Jorge Gómez-Arnau","jorge.gomezarnau@salud.madrid.org",{"facility":91,"status":52,"city":54,"state":54,"zip":92,"country":56,"countryCode":57,"cosmosGeoPoint":93,"geoPoint":95,"contacts":96},"Hospital Universitario La Paz","28046",{"type":59,"coordinates":94},[73,74],{"lat":74,"lon":73},[97],{"name":98,"role":43,"phone":34,"phoneExt":34,"email":99},"Rosa Villanueva Peña, PhD","rosa.villanueva@salud.madrid.org",{"facility":101,"status":52,"city":102,"state":54,"zip":103,"country":56,"countryCode":57,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Hospital Universitario Puerta de Hierro-Majadahonda","Majadahonda","28222",{"type":59,"coordinates":105},[106,107],-3.87182,40.47353,{"lat":107,"lon":106},[110],{"name":111,"role":43,"phone":34,"phoneExt":34,"email":112},"María Teresa González Salvador","teresacap@hotmail.com",{"type":114,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[116,117,119,121,123,124,127],{"name":91,"class":6},{"name":118,"class":6},"Hospital Universitario Ramon y Cajal",{"name":120,"class":6},"Hospital Universitario Principe de Asturias",{"name":122,"class":6},"Quirón Madrid University Hospital",{"name":38,"class":6},{"name":125,"class":126},"Centro de Investigación Biomédica en Red de Salud Mental","NETWORK",{"name":128,"class":6},"Puerta de Hierro University Hospital","100550717","cerebral-and-anti-inflammatory-response-through-exercise---mechanisms-in-depressive-disorders-100550717",false,"NCT06450704","Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders","Inflammatory and Brain Mechanisms and Clinical and Cognitive Effects of an Exercise Intervention in Major Depressive Disorder: a Randomised Longitudinal Clinical Trial.","CARE-MIND","Inclusion Criteria:\n\n* A diagnosis of Major Depressive Disorder (MDD) according to DSM-5 criteria (through the Mini International Neuropsychiatric Interview (MINI)\n* Severity of depression according to the Hamilton Depression Rating Scale 17 items (HAM-D17): minimum of 14 cut-off score of moderate depression.\n* Outpatient clinical care.\n* Current antidepressant treatment that will be maintained during the 12 weeks of the physical exercise intervention.\n\nExclusion Criteria:\n\n* Diagnosis of any axis I diagnosis except for MDD;\n* Contraindications for Magnetic Resonance Imaging.\n* Antiinflammatory treatments or antibiotics within the week before randomisation.\n* Vaccines within the month before randomisation.\n* Fever (\\>38ºC) at the moment of study entry.\n* Pregnant women.\n* Alcohol or drug abuse.","ALL","18 Years","65 Years",{"count":141,"type":142},124,"ESTIMATED","INTERVENTIONAL",[145],"NA","The goal of this clinical trial is to study how physical exercise works when applied to patients diagnosed with Major Depressive Disorder (MDD). The main questions it aims to answer are:\n\n* What are the antiinflammatory and oxidative stress and neural mechanisms involved in the antidepressant effects of exercise?\n* How effective is a physical exercise program in MDD patients in real-life conditions?\n\nThe experimental group will receive an exercise intervention as an add-on to their usual treatment (antidepressant treatment prescribed by the attending specialist). Researchers will compare to a control group, which will only receive standard treatment (antidepressant treatment prescribed by the attending specialist) and will be instructed to not change their usual physical activity. The aim is to see if a physical exercise intervention would induce a significant improvement in depressive symptoms and which mechanisms are responsible for this result.",[148,149],"Major Depressive Disorder","Inflammatory Response",[148,22,151,152],"Inflammation","Neuroimaging","2026-01-05",{"date":155,"type":156},"2026-01-06","ACTUAL",{"date":158,"type":156},"2025-04-21",{"date":160,"type":142},"2026-12-31",{"name":5,"class":6},5]