[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644541":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":25,"responsibleParty":42,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":25,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":66,"whyStopped":25,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":25},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group:","EXPERIMENTAL","Participants randomized to the intervention group will receive individualized intraoperative blood pressure management guided by real-time cerebral autoregulation monitoring to protect against both hypo- and hyper-cerebral perfusion.\n\nCerebral autoregulation will be assessed using the cerebral blood volume reactivity index (VRx), defined as the Pearson correlation coefficient between blood volume index (BVI) and mean arterial pressure (MAP). The lower and upper limits of autoregulation will be identified as the MAP values at which VRx exceeds 0.3.\n\nIf VRx remains outside the autoregulatory range for more than 60 seconds, the anesthesiologist may intervene to restore MAP within the individualized autoregulatory zone. The type and sequence of interventions will be at the discretion of the attending anesthesiologist.",[13],"Device: Mespere NeuroOs (Mespere Life Sciences) monitor",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group:","ACTIVE_COMPARATOR","In the control group, the cerebral oximetry monitor will be electronically blinded, although data will be continuously recorded for subsequent analysis. Intraoperative blood pressure management will follow current institutional standard practice at the discretion of the attending anesthesiologist.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Mespere NeuroOs (Mespere Life Sciences) monitor","bilateral Mespere NeuroOs cerebral oximeter sensors will be placed on the fronto-temporal area on the fronto-temporal area of all patients.",[15,9],null,[27],{"name":28,"affiliation":29,"role":30},"George Djaiani","Toronto General Hospital","PRINCIPAL_INVESTIGATOR",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"George Djaiani, MD FRCAFRCPS","CONTACT","416-340-4800","6205","george.djaiani@uhn.ca",{"name":39,"role":34,"phone":35,"phoneExt":40,"email":41},"Deep Grewal","4221","deep.grewal@uhn.ca",{"type":43,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100644541","cerebral-autoregulation-and-delirium-study-100644541",false,"NCT07671404","Cerebral Autoregulation and Delirium Study","Reducing Delirium After Cardiac Surgery: Personalized Targeted Blood Pressure Management Strategy Using Cerebral Autoregulation Monitoring: A Pilot Study","AUTO-POD","Inclusion Criteria:\n\n• Consenting patients aged ≥ 60 years undergoing elective complex cardiac surgery (coronary artery bypass grafting plus valve surgery, double-valve surgery, triple-valve surgery, redo operations, or aortic arch surgery), or patients aged ≥ 70 years undergoing isolated coronary artery bypass grafting or single-valve repair\u002Freplacement surgery.\n\nExclusion Criteria:\n\n* Patients with symptomatic cerebrovascular disease.\n* History of delirium.\n* Major neurocognitive impairment (e.g., dementia or Mini-Mental State Examination score \\\u003C 10).\n* Schizophrenia.","ALL","60 Years",{"count":55,"type":56},60,"ESTIMATED","INTERVENTIONAL",[59],"NA","Approximately one in four elderly patients develops postoperative delirium (POD) after cardiac surgery. POD is associated with prolonged hospitalization, increased mortality, and higher health care costs. While patient-related risk factors are often difficult to modify, surgery- and anesthesia-related factors may be optimized to reduce the incidence of POD. One potentially modifiable factor is intraoperative blood pressure management. Current practice commonly relies on standardized blood pressure targets during cardiac surgery; however, this \"one-size-fits-all\" approach may not account for individual variability in cerebral perfusion requirements. This study proposes a personalized blood pressure management strategy based on real-time monitoring of cerebral autoregulation, with the goal of maintaining optimal cerebral perfusion and protecting the brain from both hypo- and hyper-perfusion",[62,63],"Delirium - Postoperative","Cardiac Surgery",[65],"Cerebral Autoregulation Monitoring","NOT_YET_RECRUITING","2026-06-22",{"date":69,"type":70},"2026-06-26","ACTUAL",{"date":72,"type":56},"2026-06-01",{"date":74,"type":56},"2028-06-30",{"name":5,"class":6}]