[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553034":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":27,"responsibleParty":82,"collaborators":85,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":98,"sex":103,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":10,"studyType":109,"phases":10,"briefSummary":110,"conditions":111,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"msTBI",null,"Subjects with moderate to severe TBI within the first week after initial injury",{"label":13,"type":10,"description":14,"interventionNames":10},"Orthopedic control","Orthopedic trauma controls within the first week after initial injury",[16],{"name":17,"affiliation":5,"role":18},"Kan Ding, MD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","214-648-3571","kan.ding@utsouthwestern.edu",{"name":25,"role":21,"phone":22,"phoneExt":10,"email":26},"Jill Morales, MS","Epitbiresearch@utsouthwestern.edu",[28,52,64],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Texas Health Presbyterian Hospital","RECRUITING","Dallas","Texas","75231","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-96.80667,32.78306,{"lat":40,"lon":39},[43,46,49,50],{"name":44,"role":21,"phone":10,"phoneExt":10,"email":45},"Philip Edmundson, MD","philipedmundson@texashealth.org",{"name":47,"role":21,"phone":10,"phoneExt":10,"email":48},"Jill Morales, BA","jill.morales@utsouthwestern.edu",{"name":17,"role":18,"phone":10,"phoneExt":10,"email":10},{"name":44,"role":51,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"facility":53,"status":30,"city":31,"state":32,"zip":54,"country":34,"countryCode":35,"cosmosGeoPoint":55,"geoPoint":57,"contacts":58},"Parkland Health and Hospital System","75235",{"type":37,"coordinates":56},[39,40],{"lat":40,"lon":39},[59,62],{"name":60,"role":21,"phone":10,"phoneExt":10,"email":61},"Alex Valadka, MD","alex.valadka@utsouthwestern.edu",{"name":63,"role":51,"phone":10,"phoneExt":10,"email":10},"Alex Valadka",{"facility":65,"status":30,"city":31,"state":32,"zip":66,"country":34,"countryCode":35,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"UT Southwestern Medical Center","75390",{"type":37,"coordinates":68},[39,40],{"lat":40,"lon":39},[71,72,73,74,76,78,80],{"name":17,"role":21,"phone":10,"phoneExt":10,"email":23},{"name":47,"role":21,"phone":10,"phoneExt":10,"email":48},{"name":17,"role":18,"phone":10,"phoneExt":10,"email":10},{"name":75,"role":18,"phone":10,"phoneExt":10,"email":10},"Rong Zhang, PhD",{"name":77,"role":18,"phone":10,"phoneExt":10,"email":10},"David Zhu, PhD",{"name":79,"role":51,"phone":10,"phoneExt":10,"email":10},"C M Cullum, PhD",{"name":81,"role":51,"phone":10,"phoneExt":10,"email":10},"Yulun Liu, PhD",{"type":18,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kan Ding","Associate Professor",[86,88,90,93],{"name":87,"class":6},"Albert Einstein College of Medicine",{"name":89,"class":6},"Texas Health Resources",{"name":91,"class":92},"Institute for Exercise and Environmental Medicine","UNKNOWN",{"name":94,"class":95},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100553034","cerebral-autoregulation-brain-perfusion-and-neurocognitive-outcomes-after-traumatic-brain-injury-100553034",false,"NCT06480838","Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury","CAPCOG-TBI","Inclusion Criteria:\n\n* Documented\u002FVerified TBI (ACRM Criteria) (eg, motor vehicle (MV) occupant, MV pedestrian\u002Fcyclist, fall, other non-intentional, violence\u002Fassault)\n* A documented moderate to severe TBI defined as: Glasgow Coma Scale (GCS) \\\u003C 13, or loss of consciousness (LOC) \\> 30 minutes, or posttraumatic amnesia (PTA) \\> 24 hours or intracranial neuroimaging abnormalities\n* Between the age 18 - 80 year-old\n* ≤ 1 week postinjury\n* Acute brain CT for clinical care\n* Admitted to the hospital for TBI\n* Visual acuity\u002Fhearing adequate for testing\n* Fluent in English or Spanish\n* Patient or LAR ability to provide informed consent\n\nExclusion Criteria:\n\n* Age greater or less than the range 18-80 years\n* Significant polytrauma that would interfere with follow-up and outcome assessment\n* Major debilitating baseline mental health disorders (e.g., schizophrenia, bipolar disorder, severe depression with active suicidal thoughts at the time of evaluation) that would interfere with follow-up and the validity of outcome assessment.\n* Major debilitating neurological disease (e.g., stroke, CVA, dementia, tumor) impairing baseline awareness, cognition, or validity of follow-up and outcome assessment.\n* Significant history of pre-existing conditions that would interfere with follow-up and outcome assessment (e.g., active substance abuse, alcoholism, HIV\u002FAIDs, end-stage cancers, learning disabilities, developmental disorders)\n* Patients on psychiatric hold\n* Prisoners or patients in custody\n* Pregnancy in female subjects\n* Low likelihood of follow-up (e.g., participants or family indicating low interest, residence in another state or country, homeless or lack of reliable contacts)\n* Current participant in an interventional trial (e.g., drug, device, behavioral)\n* Penetrating TBI\n* Spinal cord injury with ASIA score of C or worse\n* Contraindications to MRI","ALL","18 Years","80 Years",{"count":107,"type":108},130,"ESTIMATED","OBSERVATIONAL","Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (\\\u003C 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition and prevent neurodegeneration after msTBI.",[112,113,114,115,116],"Traumatic Brain Injury With Loss of Consciousness","Brain Injury Traumatic Severe","Brain Injury Traumatic Moderate","TBI (Traumatic Brain Injury)","TBI","2026-06-30",{"date":119,"type":120},"2026-07-02","ACTUAL",{"date":122,"type":120},"2023-09-01",{"date":124,"type":108},"2029-05-31",{"name":5,"class":6},3]