[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100441475":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":33,"responsibleParty":51,"collaborators":54,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":86,"studyType":87,"phases":10,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"sCAS patients",null,"Investigators plan to enroll 850 patients of symptomatic cerebral atherosclerotic stenosis (sCAS) for cerebral autoregulation assessment to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.",[13],"Diagnostic Test: Cerebral autoregulation assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Cerebral autoregulation assessment","Cerebral autoregulation assessment will be conducted by specialized neurovascular ultrasound doctors during 0-3 and 10-30 days after stroke onset.The recorded data will be stored for further cerebral autoregulation analysis.",[9],[21],{"name":22,"affiliation":23,"role":24},"Yi Yang, MD, PhD","Neuroscience Center, Department of Neurology, The First Hospital of Jilin University","STUDY_CHAIR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","0086-13756661217","doctor_yangyi@163.com",{"name":31,"role":27,"phone":10,"phoneExt":10,"email":32},"Zhenni Guo, MD","zhen1ni2@163.com",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"the First Hospital of Jilin University","RECRUITING","Changchun","Jilin","130000","China","CN",{"type":43,"coordinates":44},"Point",[45,46],125.32278,43.88,{"lat":46,"lon":45},[49],{"name":50,"role":27,"phone":10,"phoneExt":10,"email":10},"Yi Yang",{"type":52,"investigatorFullName":50,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Associated Dean of First Hospital of Jilin University",[55,57,59,61,63,65,67,69,71],{"name":56,"class":6},"Shenzhen Second People's Hospital",{"name":58,"class":6},"Shanghai Jiao Tong University Affiliated Sixth People's Hospital",{"name":60,"class":6},"The First Affiliated Hospital with Nanjing Medical University",{"name":62,"class":6},"The First Affiliated Hospital of University of South China",{"name":64,"class":6},"Eighth Affiliated Hospital, Sun Yat-sen University",{"name":66,"class":6},"The First Affiliated Hospital of Hebei North University",{"name":68,"class":6},"Qilu Hospital of Shandong University",{"name":70,"class":6},"The Affiliated Hospital of Qingdao University",{"name":72,"class":6},"The Affiliated Hospital of Yanbian University","100441475","cerebral-autoregulation-in-patients-with-symptomatic-cerebral-atherosclerotic-stenosis-100441475",false,"NCT05028855","Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis","CASCAS","Inclusion Criteria:\n\n* Age ranging from 18 to 80, both genders\n* Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)\n* Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area\n* Onset of disease \\\u003C30 d before enrollment\n* Modified Ranking Scale (mRS) ≤1 before stroke onset\n* National Institutes of Health Stroke Scale (NIHSS) ≤20\n* Sufficient bilateral temporal bone windows for insonation of the middle cerebral artery\n* Be conscious, and able to cooperate with CA assessment\n* Willing to participate and sign the informed consent\n\nExclusion Criteria:\n\n* Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or posterior cerebral artery (PCA) stenosis; Bilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis(rate of stenosis ranging from 50-99%)\n* Patients who have received or plan to undergo intravascular interventional treatment\u002Fendarterectomy\n* Other intracranial diseases, including cerebral hemorrhage (primary or secondary), intracranial neoplasm, aneurysm, arteriovenous malformation, etc.\n* Evidence for embolic stroke, such as atrial fibrillation, prosthetic valve surgery, and suspected endocarditis, etc.\n* Arrhythmia, anemia and hyperthyroidism which may influence the stability of cerebral blood flow diagnosed by two physicians by electrocardiogram and laboratory tests.\n* Dementia, severe anxiety, depression, and other mental diseases\n* Malignant neoplasm and expected lifetime \\\u003C2 years\n* Enrolled in other clinical trails within 6 months","ALL","18 Years","80 Years",{"count":84,"type":85},850,"ESTIMATED","24 Months","OBSERVATIONAL","In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.",[90,91],"Cerebrovascular Stroke","Cerebral Artery Stenosis",[93,94,95,96],"cerebral atherosclerotic stenosis","ischemic stroke","transient ischemic attack","cerebral autoregulation","2024-02-29",{"date":99,"type":100},"2024-03-01","ACTUAL",{"date":102,"type":100},"2017-01-14",{"date":104,"type":85},"2026-08-30",{"name":50,"class":6},1]