[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100491342":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":38,"locations":44,"responsibleParty":166,"collaborators":168,"id":172,"slug":173,"hasResults":174,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":10,"eligibilityCriteria":178,"healthyVolunteers":179,"sex":180,"minAge":181,"maxAge":10,"enrollmentInfo":182,"targetDuration":10,"studyType":185,"phases":10,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":204},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-Carrier Cohort",null,"About 100 participants who are at-risk, healthy family members with No NOTCH3 Mutation and no symptoms or signs of cognitive decline.",[13],"Other: Study Procedures",{"label":15,"type":10,"description":16,"interventionNames":17},"Pre-Symptomatic NOTCH3 Cohort","About 133 participants who are pre-symptomatic, at-risk, and healthy (with verified NOTCH3 mutation) family members with no symptoms.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Symptomatic NOTCH3 Cohort - No Functional Decline","About 134 participants who are symptomatic (with verified NOTCH3 mutation) family members and no functional decline (e.g., mild cognitive impairment (MCI) with premorbid functional levels maintained).",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Symptomatic NOTCH3 Cohort - Functional Decline","About 133 participants who are symptomatic family members with a verified NOTCH3 CADASIL mutation and evidence of functional decline consistent with early dementia.",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Study Procedures","Participants will experience\n\n* Neurocognitive Tests and Self-Report Measures\n* Clinical Interviews\n* Neurological Exam\n* MRI screening at baseline, 18 months, 36 months\n* Fasted Blood draw",[9,15,23,19],[32,35],{"name":33,"affiliation":5,"role":34},"Jane S Paulsen, PhD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Michael D Geschwind, MD","University of California, San Francisco",[39],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"Cadasil Consortium","CONTACT","1-833-795-3016","info@cadasil-consortium.org",[45,59,67,77,87,97,106,116,126,137,146,156],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":10},"University of California","RECRUITING","Los Angeles","California","90095","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-118.24368,34.05223,{"lat":57,"lon":56},{"facility":46,"status":47,"city":60,"state":49,"zip":61,"country":51,"countryCode":52,"cosmosGeoPoint":62,"geoPoint":66,"contacts":10},"San Francisco","94143",{"type":54,"coordinates":63},[64,65],-122.41942,37.77493,{"lat":65,"lon":64},{"facility":68,"status":47,"city":69,"state":70,"zip":71,"country":51,"countryCode":52,"cosmosGeoPoint":72,"geoPoint":76,"contacts":10},"University of Colorado","Denver","Colorado","80204",{"type":54,"coordinates":73},[74,75],-104.9847,39.73915,{"lat":75,"lon":74},{"facility":78,"status":47,"city":79,"state":80,"zip":81,"country":51,"countryCode":52,"cosmosGeoPoint":82,"geoPoint":86,"contacts":10},"Georgia State University Research Foundation","Atlanta","Georgia","30303",{"type":54,"coordinates":83},[84,85],-84.38798,33.749,{"lat":85,"lon":84},{"facility":88,"status":47,"city":89,"state":90,"zip":91,"country":51,"countryCode":52,"cosmosGeoPoint":92,"geoPoint":96,"contacts":10},"Loyola University","Chicago","Illinois","60660",{"type":54,"coordinates":93},[94,95],-87.65005,41.85003,{"lat":95,"lon":94},{"facility":98,"status":47,"city":99,"state":99,"zip":100,"country":51,"countryCode":52,"cosmosGeoPoint":101,"geoPoint":105,"contacts":10},"Columbia University","New York","10027",{"type":54,"coordinates":102},[103,104],-74.00597,40.71427,{"lat":104,"lon":103},{"facility":107,"status":47,"city":108,"state":109,"zip":110,"country":51,"countryCode":52,"cosmosGeoPoint":111,"geoPoint":115,"contacts":10},"Oregon Health & Science University","Portland","Oregon","97239",{"type":54,"coordinates":112},[113,114],-122.67621,45.52345,{"lat":114,"lon":113},{"facility":117,"status":47,"city":118,"state":119,"zip":120,"country":51,"countryCode":52,"cosmosGeoPoint":121,"geoPoint":125,"contacts":10},"Brown University","Providence","Rhode Island","02912",{"type":54,"coordinates":122},[123,124],-71.41283,41.82399,{"lat":124,"lon":123},{"facility":127,"status":128,"city":129,"state":130,"zip":131,"country":51,"countryCode":52,"cosmosGeoPoint":132,"geoPoint":136,"contacts":10},"University of Texas Health Science Center","NOT_YET_RECRUITING","Houston","Texas","77030",{"type":54,"coordinates":133},[134,135],-95.36327,29.76328,{"lat":135,"lon":134},{"facility":138,"status":128,"city":139,"state":130,"zip":140,"country":51,"countryCode":52,"cosmosGeoPoint":141,"geoPoint":145,"contacts":10},"University of Texas","San Antonio","78249",{"type":54,"coordinates":142},[143,144],-98.49363,29.42412,{"lat":144,"lon":143},{"facility":147,"status":47,"city":148,"state":149,"zip":150,"country":51,"countryCode":52,"cosmosGeoPoint":151,"geoPoint":155,"contacts":10},"University of Utah","Salt Lake City","Utah","84112",{"type":54,"coordinates":152},[153,154],-111.89105,40.76078,{"lat":154,"lon":153},{"facility":157,"status":47,"city":158,"state":159,"zip":160,"country":51,"countryCode":52,"cosmosGeoPoint":161,"geoPoint":165,"contacts":10},"University of Washington","Seattle","Washington","98195",{"type":54,"coordinates":162},[163,164],-122.33207,47.60621,{"lat":164,"lon":163},{"type":167,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[169],{"name":170,"class":171},"National Institute on Aging (NIA)","NIH","100491342","cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil-study-100491342",false,"NCT05677880","Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study","Unraveling the Early Phases of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)","Inclusion Criteria for CADASIL Participants:\n\n1. Must be at least 18 years old\n2. Positive NOTCH3 genetic testing; OR a positive skin biopsy; OR a willingness to have a NOTCH3 genetic test completed prior to enrolling AND are at-risk for, or diagnosed clinically with, CADASIL\n3. Willing to commit to three in-person visits (a baseline visit, an 18-month follow-up, and a 36-month follow-up) and to remote visits as needed by phone, email, mail or internet\n4. Willing to provide documentation of all current medications to study team\n\n   a. All medications will be allowed throughout the course of study. Documentation of medications will be used for analyses to assess potential impact of medications on study outcomes.\n5. Willing and able to undergo an MRI scan and blood draw at each in-person visit\n6. Must have a designated \"study companion\"\n\n   a. A \"study companion\" is someone who knows the participant well (has greater than or equal to 3 hours\u002Fmonth of contact with the CADASIL participant) and can provide additional information to the study team (either remotely or in-person).\n7. A functional capacity less than 4 on the Modified Rankin Scale\n\nInclusion Criteria for Healthy Controls (HC):\n\n1\\. Must meet same criteria as CADASIL participants, EXCEPT have negative NOTCH3 genetic testing\n\nExclusion Criteria:\n\n1. History of severe learning disability, intellectual disability, or other neurological disease or event not attributable to CADASIL\n2. History of serious alcohol or drug abuse within the past year\n3. Unwilling to undergo NOTCH3 genetic testing if there is no test on file",true,"ALL","18 Years",{"count":183,"type":184},660,"ESTIMATED","OBSERVATIONAL","This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.",[188],"CADASIL",[190,191,192,193,194],"neurodegeneration","dementia","cognitive impairment","NOTCH3","vascular dementia","2026-01-14",{"date":197,"type":198},"2026-01-15","ACTUAL",{"date":200,"type":198},"2022-06-03",{"date":202,"type":184},"2027-08",{"name":5,"class":6},12]