[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628588":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":40,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":10,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Seoul National University Bundang Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Older patients undergoing elective laparoscopic surgery",null,"Adults aged 65 years and older undergoing elective laparoscopic surgery under general anesthesia will be prospectively observed. During surgery, cerebral oxygen levels will be measured using a non-invasive forehead sensor to assess the brain's oxygen utilization response within the range of routine anesthesia care. Participants will be followed for up to three days after surgery to evaluate the occurrence of postoperative delirium.",[13],"Other: Intraoperative Cerebral Oxygen Utilization Assessment",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Intraoperative Cerebral Oxygen Utilization Assessment","Cerebral oxygenation will be monitored intraoperatively using a non-invasive forehead sensor based on functional near-infrared spectroscopy technology. During general anesthesia, the fraction of inspired oxygen (FiO₂) may be temporarily adjusted within the standard clinical range used in routine anesthesia care to evaluate the brain's oxygen utilization response. No experimental oxygen levels or additional therapeutic interventions will be administered beyond standard clinical practice.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Soowon Lee, MD, PhD","CONTACT","+82-31-787-7499","soowonlee@snubh.org",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":10,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"RECRUITING","Seongnam-si","Gyeonggi-do","13620","South Korea",{"type":33,"coordinates":34},"Point",[35,36],127.13778,37.43861,{"lat":36,"lon":35},[39],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},{"type":41,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100628588","cerebral-oxygen-consumption-response-to-increased-oxygen-supply-and-postoperative-delirium-in-older-surgical-patients-100628588",false,"NCT07463586","Cerebral Oxygen Consumption Response to Increased Oxygen Supply and Postoperative Delirium in Older Surgical Patients","Association Between Cerebral Oxygen Consumption Responsiveness to Increased Oxygen Supply and Postoperative Delirium: A Prospective Observational Study Using Functional Near-Infrared Spectroscopy","Inclusion Criteria:\n\n* Patients undergoing elective laparoscopic surgery under general anesthesia\n* Age 65 years or older\n\nExclusion Criteria:\n\n* Diagnosis of dementia or presence of delirium before surgery\n* Loss of capacity to provide informed consent\n* Moderate or severe cerebrovascular stenosis diagnosed before surgery\n* Moderate or severe obstructive or restrictive pulmonary dysfunction identified on preoperative pulmonary function testing\n* Requirement for supplemental oxygen therapy before surgery\n* History of neurological disorders (e.g., Parkinson's disease, stroke) or prior brain surgery\n* Severe hepatic dysfunction (AST or ALT \\> 120 IU\u002FL)\n* Severe renal dysfunction (estimated GFR \\\u003C 15 mL\u002Fmin\u002F1.73 m²)\n* Persistent severe hemodynamic instability (mean arterial pressure \\\u003C 60 mmHg)\n* Skin conditions preventing placement of the forehead fNIRS sensor\n* Combined surgical procedures performed concurrently\n* Planned postoperative admission to the intensive care unit","ALL","65 Years",{"count":52,"type":53},80,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether the brain's ability to use oxygen during surgery is associated with postoperative delirium in adults aged 65 years and older undergoing general anesthesia.\n\nThe main question it aims to answer is:\n\n\\- Does reduced cerebral oxygen consumption responsiveness during surgery increase the risk of postoperative delirium in older patients?\n\nParticipants who are undergoing elective laparoscopic surgery under general anesthesia as part of their routine medical care will have brain oxygen levels measured during surgery using a non-invasive forehead sensor, and will be assessed for delirium for up to three days after surgery.",[57,58],"Delirium - Postoperative","Cerebral Oxygenation","2026-03-29",{"date":61,"type":62},"2026-04-02","ACTUAL",{"date":64,"type":62},"2026-03-11",{"date":66,"type":53},"2028-05",{"name":5,"class":6},1]