[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515833":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":35,"responsibleParty":64,"collaborators":19,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":19,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":19,"enrollmentInfo":76,"targetDuration":19,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":19,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"ST-MRI scans","All patients will undergo Saturation Transfer (ST)-MRI during their standard of care imaging visits (or within 14 days of their standard MRI).",[12],"Diagnostic Test: Saturation Transfer (ST)-MRI",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Saturation Transfer (ST)-MRI","Non-contrast magnetic resonance imaging \"Saturation Transfer\" scans consisting of magnetization transfer (MT) and chemical exchange saturation transfer (CEST)",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Greg J Stanisz, PhD","PRINCIPAL_INVESTIGATOR",[25,31],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Mary Jane Lim-Fat, MD","CONTACT","416-480-6100","61960","MaryJane.LimFat@sunnybrook.ca",{"name":32,"role":27,"phone":33,"phoneExt":19,"email":34},"Arjun Sahgal, MD","(416) 480-4998","Arjun.Sahgal@sunnybrook.ca",[36,52],{"facility":5,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Toronto","Ontario","M4N3M5","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-79.39864,43.70643,{"lat":47,"lon":46},[50],{"name":51,"role":27,"phone":19,"phoneExt":19,"email":19},"Mary Jane MaryJane.LimFat@sunnybrook.ca, MD",{"facility":53,"status":54,"city":38,"state":39,"zip":55,"country":41,"countryCode":42,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"St. Michael's Hospital","NOT_YET_RECRUITING","M5B 1W8",{"type":44,"coordinates":57},[46,47],{"lat":47,"lon":46},[60],{"name":61,"role":27,"phone":62,"phoneExt":19,"email":63},"Sunit Das, MD, PhD","(416) 864-5548","sunit.das@utoronto.ca",{"type":23,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Dr. MaryJane Lim Fat","Principal Investigator","100515833","cest-in-low-grade-glioma-study-100515833",false,"NCT05996653","CEST in Low-grade Glioma Study","A Multi-institutional Observational Study of CEST Imaging in Low-grade Glioma","Inclusion Criteria:\n\n1. Be at least 12 years of age;\n2. Diagnosed with:\n\n   1. Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and\u002For clinical findings; or\n   2. Cohort B (post-surgical): IDH1\u002F2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation\n3. No contraindications to MRI;\n4. eGFR \\> 30 ml\u002Fmin;\n5. No prior chemotherapy or radiation therapy;\n6. No need for upfront treatment (surgery, chemotherapy, and\u002For radiation therapy)\n7. Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital\n\nExclusion Criteria:\n\n1. Need for upfront post-surgical treatment with either chemotherapy and\u002For radiation therapy\n2. Pregnancy","ALL","12 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","Low grade gliomas (LGGs) are malignant, infiltrative and incurable brain tumours that typically present in the younger population. This project proposes to use non-contrast metabolic \"Saturation Transfer\" (ST)-MRI to evaluate LGG tumour progression and aims to predict early changes in LGG. Early identification of LGG patients whose tumours will progress will permit early interventions. ST-MRI does not involve any intravenous injection of contrast and which acquires metabolic information not seen by standard MRI.",[84],"Low-grade Glioma","2023-08-10",{"date":87,"type":88},"2023-08-18","ACTUAL",{"date":90,"type":88},"2022-08-12",{"date":92,"type":78},"2028-08-12",{"name":5,"class":6},2]