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age\n\nCase Exclusion Criteria:\n\n* Currently receiving any treatment for cancer\n* Currently taking any demethylating agents\u002FDNA hypomethylating agents\n* Simultaneously diagnosed with two or more invasive cancers\n* Diagnosed with any invasive or non-invasive cancer in addition to the index cancer in the last 5 years\n* Currently diagnosed with any chronic hematopoietic cancer (e.g. chronic CLL) in addition to the index cancer\n* Currently diagnosed with any myelodysplastic syndromes and\u002For precursor hematologic conditions (e.g. MGUS) in addition to the index cancer\n* Women who are known to be pregnant (self-reported)\n\nControl Inclusion Criteria\n\n* Not diagnosed with any cancer in the last 5 years (non-invasive cancer is allowed)\n* Able and willing to provide informed consent\n* ≥40 years of age\n\nControl Exclusion Criteria\n\n* Currently receiving any treatment for cancer\n* Currently taking any demethylating agents\u002FDNA hypomethylating agents\n* Women who are known to be pregnant (self-reported)",true,"ALL","40 Years",{"count":316,"type":317},7000,"ESTIMATED","OBSERVATIONAL","This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mortality to maximize impact on clinical care.\n\nAdditionally, the ability of the whole-genome methylome enrichment platform to detect minimal residual disease after completion of cancer treatment and to detect relapse prior to clinical presentation will be evaluated in lung cancer. This cancer was selected based on the existing clinical landscape and treatment availability.",[321,322,323,324,325,326,327,328,329,330,331,332,333,334,335,336,337,338,339,340],"Brain Cancer","Breast Cancer","Bladder Cancer","Cervical Cancer","Colorectal Cancer","Endometrial Cancer","Esophageal Cancer","Stomach Cancer","Head and Neck Cancer","Hepatobiliary Cancer","Leukemia","Lung Cancer","Lymphoma","Multiple Myeloma","Ovarian Cancer","Pancreatic Cancer","Prostate Cancer","Renal Cancer","Sarcoma","Thyroid Cancer",[342,343,344,345,346],"Multi-cancer early detection","Liquid Biopsy","Methylome","Cancer screening","cell-free DNA","2026-01-16",{"date":349,"type":350},"2026-01-20","ACTUAL",{"date":352,"type":350},"2022-05-03",{"date":354,"type":317},"2027-03",{"name":5,"class":6},17]