[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100463159":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":69,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"PEA cohort",null,"patients with CTEPH receiving PEA",[13],"Procedure: pulmonary endarterectomy or balloon pulmonary angioplasty",{"label":15,"type":10,"description":16,"interventionNames":17},"BPA cohort","patients with CTEPH receiving BPA",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Pulmonary arterial hypertension (PAH)-specific medication","CTEPH patients without PEA or BPA, treatment with any PAH-specific medication, i.e. endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, soluble guanylate cyclase stimulators, drugs acting on the prostanoid pathway and prostaglandin I2 receptor agonists",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","pulmonary endarterectomy or balloon pulmonary angioplasty","A multidisciplinary team make the final treatments for patients with CTEPH depending on their disease and preferences.",[15,9,19],[29],"PEA or BPA",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhenguo Zhai, Ph.D.","CONTACT","+86 10 84206269","zhaizhenguo2011@126.com",[37],{"facility":38,"status":39,"city":40,"state":10,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"China-Japan Frendship hospital","RECRUITING","Beijing","100029","China","CN",{"type":45,"coordinates":46},"Point",[47,48],116.39723,39.9075,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhenguo Zhai, Ph D",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhenguo Zhai,MD,PhD","Principal Investigator","100463159","change-a-multi-center-chronic-thromboembolic-pulmonary-hypertension-cteph-database-in-china-100463159",false,"NCT05311072","Change-a Multi-center Chronic Thromboembolic Pulmonary Hypertension （CTEPH） Database in China","A Chinese Real-world Study to Investigate the Management Pattern and Outcomes of Chronic Thromboembolic Pulmonary Hypertension (CHANGE Study)","Inclusion Criteria:\n\n1. Patients must be diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH)\n2. Patients must be willing to provide informed consent\n3. Patients must meet the following criteria for CTEPH:\n\na mean pulmonary artery pressures (mPAP) ≥20 mmHg combined with a pulmonary vascular resistance (PVR) ≥ 3 WU and pulmonary arterial wedge pressure (PAWP)≤ 15 mmHg documented at right heart catheterization with radiographic evidence of organized thrombi involving the pulmonary arteries after 3 months of effective anticoagulation.\n\nExclusion Criteria:\n\n1. Main cause of PH other than CTEPH\n2. Participation in a therapeutic clinical trial with an unknown drug;\n3. Withdrawal or lack of informed consent.","ALL","14 Years",{"count":67,"type":68},1500,"ESTIMATED","3 Years","OBSERVATIONAL","The Change Database is a prospective, observational multi-center disease registry, which will collect data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China. It aims to illustrate the epidemiology, management and long-term outcomes of CTEPH.",[73],"Chronic Thromboembolic Pulmonary Hypertension",[73,75,76,77,78,79,80],"epidemiology","diagnosis","treatment","prognosis","balloon pulmonary angioplasty","pulmonary endarterectomy","2024-01-20",{"date":83,"type":84},"2024-01-23","ACTUAL",{"date":86,"type":84},"2015-10-01",{"date":88,"type":68},"2027-12-31",{"name":5,"class":6},1]