[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100309771":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":55,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Indiana University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Eosinophilic Esophagitis patients",null,"PPI treatment",[13],"Diagnostic Test: endoflip",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","endoflip","Resolution of esophageal eosinophilia by a 2-month course of high dose PPI in patients will lead to improvement in esophageal distensibility, and thus should produce improvement in dysphagia symptoms.",[9],[21],{"name":22,"affiliation":5,"role":23},"Akiro Saito, MD","PRINCIPAL_INVESTIGATOR",[25,29],{"name":26,"role":27,"phone":10,"phoneExt":10,"email":28},"Maureen Schilling","CONTACT","maschi@iu.edu",{"name":30,"role":27,"phone":31,"phoneExt":10,"email":32},"Lainna Cohen","3172780621","larcohen@iu.edu",[34,51],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Indiana University Health University Hospital","RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-86.15804,39.76838,{"lat":46,"lon":45},[49,50],{"name":26,"role":27,"phone":10,"phoneExt":10,"email":28},{"name":22,"role":23,"phone":10,"phoneExt":10,"email":10},{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":52,"geoPoint":54,"contacts":10},{"type":43,"coordinates":53},[45,46],{"lat":46,"lon":45},{"type":23,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Akira Saito","Assistant Professor of Clinical Medicine","100309771","changes-in-esophageal-distensibility-with-proton-pump-inhibitors-in-patients-with-esophageal-eosinophilia-a-pilot-study-100309771",false,"NCT03312686","Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study","EOE","Inclusion Criteria:\n\n1\\. Presence of eosinophilia on esophageal biopsy, defined as a peak count of \\> 15 eosinophils per high power field (HPF) on light microscopy based on biopsies from at least 2 of the 3 biopsy segments (upper, middle and distal esophagus)\n\nExclusion Criteria:\n\n1. Secondary causes of esophageal eosinophilia has been excluded, such as eosinophilic GI diseases, celiac disease, Crohn's disease, esophageal infection, hypereosinophilic syndrome, drug hypersensitivity, vasculitis, pemphigus, connective tissue diseases, graft vs. host disease\n2. Age \\\u003C 18 or \\> 65 years\n3. Contraindication for biopsy, such as presence of esophageal varices, coagulopathy\n4. History of esophageal surgery, gastric or esophageal malignancy, anatomical abnormality, or major primary motility disorder (such as achalasia)\n5. Pregnancy\n6. Prisoners","ALL","18 Years","65 Years",{"count":69,"type":70},10,"ESTIMATED","OBSERVATIONAL","This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.",[74],"Eosinophilic Esophagitis",[17],"2025-11-21",{"date":78,"type":79},"2025-11-24","ACTUAL",{"date":81,"type":79},"2016-11",{"date":83,"type":70},"2026-12-31",{"name":5,"class":6},2]