[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587208":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":28,"responsibleParty":42,"collaborators":10,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Rijeka","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Pregnant women referred for thyroid examination due to suspected thyroid disease",null,"Adult pregnant women referred to the Clinical Department of Nuclear Medicine and the Department of Endocrinology, Diabetes and Metabolic Diseases of the Clinic of Internal Medicine of the Clinical Hospital Center Rijeka for thyroid examination due to suspected or known AITD and who have signed an informed consent form will participate in the study. The following data is collected and analyzed from pregnant women who are included in the examination on the basis of a signed consent form: Age, number of pregnancies, number of abortions, pregnancy outcome (abortion, premature birth, timely birth, delayed birth). The pregnant women included in the study will be tested three times, i.e. in the first, second and third trimester of pregnancy. Depending on the results of the hormone status and the thyroid autoantibody titre, the pregnant women will be divided into two groups: (1) normal pregnancy and (2) pregnant women with autoimmune thyroid disease.",[13],{"name":14,"affiliation":15,"role":16},"Tatjana Bogović Crnčić","Faculty of Medicine University of Rijeka","PRINCIPAL_INVESTIGATOR",[18,24],{"name":19,"role":20,"phone":21,"phoneExt":22,"email":23},"Bogović Crnčić","CONTACT","0038551658365","0038551658370","tatjanabc@uniri.hr",{"name":25,"role":20,"phone":26,"phoneExt":10,"email":27},"Sotošek","0038551651185","vlatkast@uniri.hr",[29],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":10},"Faculty of Medicine University of Rijeka, Clinical Hospital Center Rijeka","Rijeka","Primorsko-goranska County","51000","Croatia","HR",{"type":37,"coordinates":38},"Point",[39,40],14.44241,45.32673,{"lat":40,"lon":39},{"type":16,"investigatorFullName":14,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Associate professor, MD, PhD, Head of the Department of Nuclear Medicine at Faculty of Medicine","100587208","changes-in-natural-immunity-in-pregnant-women-with-autoimmune-thyroid-disease-100587208",false,"NCT06925399","Changes in Natural Immunity in Pregnant Women With Autoimmune Thyroid Disease","Dynamic Changes of Innate Immune Cells in Pregnant Women With Autoimmune Thyroid Disease","CIPAT","Inclusion Criteria: adult healthy pregnant women and pregnant women with autoimmune thyroid disease\n\n* with a single pregnancy\n* older than 18 years\n* who have signed the informed consent form\n\nExclusion Criteria:\n\n* pregnant women who refuse to give informed consent\n* pregnant women under the age of 18\n* pregnant women with malignant diseases\n* pregnant women with thyrotoxicosis or hypothyroidism of a non-autoimmune nature and previous thyroidectomy or ablative therapy with iodine-131\n* pregnant women with an acute or chronic disease that is not an autoimmune thyroid disease","FEMALE","18 Years","45 Years",{"count":56,"type":57},80,"ESTIMATED","OBSERVATIONAL","Autoimmune thyroid disease (AITD) is the most common endocrine disorder in women of reproductive age, including during pregnancy. It encompasses two clinical conditions: autoimmune hyperthyroidism and hypothyroidism. Pregnancy significantly affects thyroid function regulation, while thyroid dysfunction can influence fertility, pregnancy progression, and the postpartum health. Although the role of acquired immunity in AITD is well understood, recent research increasingly emphasizes innate immunity. Key cells involved in innate immunity include neutrophils, monocytes, and NKT cells. However, limited data exist on their role during pregnancy, especially in women with AITD.\n\nThis study aims to investigate the dynamic changes in neutrophils, monocytes and NKT cells during pregnancy and compare findings between women with normal pregnancies and those with AITD.\n\nThe study will analyze the frequency and activation status of these innate immune cells in peripheral blood samples collected during the first, second, and third trimesters. In addition, concentrations of thyrotropin, thyroid hormones, thyroglobulin, and thyroid autoantibodies, will be measured. A thyroid ultrasound will also be performed.",[61,62],"Pregnancy","Autoimmune Thyroid Disease",[61,64,65,66,67,68],"Autoimmune thyroid disease","Innate immunity","NKT cells","Monocytes","Neutrophils","NOT_YET_RECRUITING","2025-04-06",{"date":72,"type":73},"2025-04-13","ACTUAL",{"date":75,"type":57},"2025-05-01",{"date":77,"type":57},"2027-05-01",{"name":5,"class":6},1]