[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563214":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":10,"centralContacts":35,"locations":44,"responsibleParty":65,"collaborators":67,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Royal Surrey County Hospital NHS Foundation Trust","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Part 1 - control patients",null,"25 healthy volunteers\n\n1 X Endothelial cell biopsy",[13],"Other: Endothelial cell biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Part 1 - surgical patients","20 surgical patients\n\n1 X Endothelial cell biopsy\n\nSamples collected at 24 hours post knife to skin to capture peak inflammation",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Part 1 - sepsis patients","20 sepsis patients\n\n1 X Endothelial cell biopsy\n\nSamples collected on admission to ICU",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Part 2 - surgical patients","20 surgical patients 3 X Endothelial cell biopsy\n\nSamples collected pre-surgery, 24 hours and 48 hours post knife to skin",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Part 2 - sepsis patients","20 sepsis patients 3 X Endothelial cell biopsy\n\nSamples collected on admission, 24 hours and 48 hours post admission to ICU",[13],[31],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Endothelial cell biopsy","Endothelial cell sample collected from the antecubital fossa of patients. A vein in the antecubital fossa is cannulated with a 20 g valveless cannula. A metal guidewire is then passed into the vessel to collect endothelial cells for analysis",[9,19,15,27,23],[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Ben Creagh-Brown, BM, PhD","CONTACT","+44 (0)1483 688 660","bencb@nhs.net",{"name":42,"role":38,"phone":39,"phoneExt":10,"email":43},"Charlie Piercy, MSc","charles.piercy@nhs.net",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Royal Surrey NHS Foundation Trust","RECRUITING","Guildford","Surrey","GU27XX","United Kingdom","UK",{"type":54,"coordinates":55},"Point",[56,57],-0.57427,51.23536,{"lat":57,"lon":56},[60,61,63],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},{"name":42,"role":38,"phone":39,"phoneExt":10,"email":62},"Charles.piercy@nhs.net",{"name":42,"role":64,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":66,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[68],{"name":69,"class":6},"University of Surrey","100563214","characterisation-of-endothelial-cells-in-different-inflammatory-pathologies-100563214",false,"NCT06613256","Characterisation of Endothelial Cells in Different Inflammatory Pathologies","JEDI-2","Inclusion Criteria:\n\nHealthy volunteer\n\n* Adult ≥ 18 years\n* Able and willing to give consent\n\nSurgical patients\n\n* Adult ≥ 18 years\n* Patients admitted to RSFT for planned major surgery\n\nCritically ill patients\n\n* Adult ≥ 18 years\n* Emergency admission to ICU at RSFT\n* Meets the sepsis 3.0 definition\n\nExclusion Criteria:\n\nHealthy volunteer\n\n* Not currently a patient within the hospital\n* Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD.\n* Not on immunomodulatory medications, such as corticosteroids\n* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)\n\nSurgical patients\n\n* Patients with restricted liberty, prisoners or under legal protection\n* Anticipated prohibitively difficult venous cannulation\n* Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, sepsis, diabetes with end organ damage, cardiovascular disease and CKD\n* Currently prescribed immunomodulatory medication or immunocompromised\n* Received chemotherapy within 2 weeks of predicted sampling\n* Receiving vasopressor support prior to surgery\n* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)\n\nCritically ill patients\n\n* Patients with restricted liberty, prisoners or under legal protection• Anticipated prohibitively difficult venous cannulation\n* Presenting with inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes with end organ damage, cardiovascular disease and CKD.\n* Currently prescribed immunomodulatory medication or immunocompromised\n* Received chemotherapy within 2 weeks of predicted sampling.\n* History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)",true,"ALL","18 Years",{"count":81,"type":82},105,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery.\n\nThe main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'",[86,87],"Sepsis","Vasoplegia","2024-09-23",{"date":90,"type":91},"2024-09-25","ACTUAL",{"date":93,"type":91},"2024-07-16",{"date":95,"type":82},"2026-11-12",{"name":5,"class":6},1]