[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100420380":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":50,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":10,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Primary Sclerosing Cholangitis (PSC)",null,"Subjects diagnosed with Primary Sclerosing Cholangitis (PSC) will be asked to provide bile and\u002For brush cytology at time of endoscopic retrograde cholangiopancreatography (ERCP) or cholecystectomy (gallbladder removal).",{"label":13,"type":10,"description":14,"interventionNames":10},"Control (non-PSC)","Subjects without a diagnosis of Primary Sclerosing Cholangitis (PSC) will be asked to provide bile and\u002For brush cytology at time of endoscopic retrograde cholangiopancreatography (ERCP) or cholecystectomy (gallbladder removal).",[16],{"name":17,"affiliation":5,"role":18},"Konstantinos Lazaridis, MD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Erik Schlicht, CCRP","CONTACT","(507) 284-4212","schlicht.erik@mayo.edu",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Jackie Bianchi","(507) 266-0346","bianchi.jackie@mayo.edu",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-92.4699,44.02163,{"lat":42,"lon":41},[45,48],{"name":46,"role":22,"phone":47,"phoneExt":10,"email":24},"Erik M Schlicht, B.A.,CCRP","507-284-4312",{"name":26,"role":22,"phone":49,"phoneExt":10,"email":28},"507-266-0346",{"type":18,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Konstantinos N. Lazaridis, M.D.","Principal Investigator",[54],{"name":55,"class":56},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100420380","characterization-of-biliary-cell-derived-organoids-from-bile-of-psc-and-non-psc-patients-100420380",false,"NCT04753996","Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients","Inclusion Criteria:\n\nPSC\n\n* Patients diagnosed with PSC between the age of 18 and 85.\n* The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.\n* Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.\n\nControls\n\n• Controls without history of PSC or evidence of other chronic liver disease of either gender that will participate in this study should be between the ages of 18-85.\n\nExclusion Criteria:\n\n* Patients unable to provide inform consent.\n* Prisoners and institutionalized individuals.\n* PSC with orthotopic liver transplantation\n* History of Roux En Y procedure",true,"ALL","18 Years","85 Years",{"count":68,"type":69},300,"ESTIMATED","OBSERVATIONAL","The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.",[73,74,75],"Primary Sclerosing Cholangitis","PSC","Cholangiocarcinoma","2026-02-12",{"date":78,"type":79},"2026-02-17","ACTUAL",{"date":81,"type":79},"2021-03-08",{"date":83,"type":69},"2035-01-01",{"name":5,"class":6},1]