[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503159":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":30,"locations":37,"responsibleParty":53,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Included patients",null,"The study population will comprise 200 (two hundred) adult patients candidate to neurosurgical treatment for newly diagnosed malignant brain tumors, able to express an informed consent.",[13,14],"Diagnostic Test: Circulating leukocytes immunophenotype","Diagnostic Test: Tumor sampling",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Circulating leukocytes immunophenotype","Blood samples will be tested with flow cytometry in order to characterize leukocyte subpopulations and to evaluate the circulating immunophenotype",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Tumor sampling","Immunohistochemical analysis will be performed on tumor samples in order to characterize immune T cells distribution within the tumor.",[9],[26],{"name":27,"affiliation":28,"role":29},"Pietro Mortini, MD, Prof.","IRCCS San Raffaele Scientific Institute","STUDY_DIRECTOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Laura Sincinelli","CONTACT","0226435568","0039","sincinelli.laura@hsr.it",[38],{"facility":28,"status":39,"city":40,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Milan","20132","Italy","IT",{"type":45,"coordinates":46},"Point",[47,48],9.18951,45.46427,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":52,"phoneExt":10,"email":36},"003926435568",{"type":54,"investigatorFullName":27,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Professor","100503159","characterization-of-circulating-and-tumor-infiltrating-immune-cells-in-malignant-brain-tumors-100503159",false,"NCT05831631","Characterization of Circulating and Tumor-infiltrating Immune Cells in Malignant Brain Tumors","Immunophenotype Characterization of Circulating and Tumor Infiltrating Immune Cells in Malignant Brain Tumors.","Inclusion criteria:\n\n* Adult patients (≥18 years)\n* Able to express informed consent\n* With primary or secondary malignant brain tumor\n* Requiring neurosurgical treatment (radiosurgery, stereotactic biopsy, surgery)\n\nExclusion Criteria:\n\n* Patients who do not meet inclusion criteria.","ALL","18 Years",{"count":66,"type":67},200,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome.\n\nParticipants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.",[71,72],"Brain Tumor, Primary","Brain Tumor - Metastatic",[74,75],"Immunophenotype","Primary and secondary brain tumor","2025-06-06",{"date":78,"type":79},"2025-06-11","ACTUAL",{"date":81,"type":79},"2022-08-01",{"date":83,"type":67},"2029-08-01",{"name":27,"class":6},1]