[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615672":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":35,"centralContacts":40,"locations":49,"responsibleParty":86,"collaborators":88,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":101,"minAge":102,"maxAge":22,"enrollmentInfo":103,"targetDuration":22,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":115,"overallStatus":52,"whyStopped":22,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Centre Hospitalier St Anne","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Cognitive assessment","EXPERIMENTAL","Neuropsychological assessment assessing different cognitive dimensions (e.g., motivation and decision-making, metacognition, access to consciousness, Bayesian inference)",[13,14,15,16],"Behavioral: Cognitive assessment","Behavioral: Brain MRI (optional)","Behavioral: Electroencephalography (optional)","Behavioral: Magnetoencephalography (optional)",[18,23,27,31],{"type":19,"name":9,"description":20,"armGroupLabels":21,"otherNames":22},"BEHAVIORAL","This intervention consists of computerized neuropsychological assessments designed to evaluate high-level cognitive impairments. The tests cover various cognitive dimensions including motivation, metacognition, conscious access, and Bayesian causal inference. These assessments are performed using computers or tablets, aiming to build a multidimensional cognitive atlas comparing patients with severe psychiatric and neurological conditions to healthy volunteers. The tests will be progressively optimized for usability and adapted to the specific difficulties faced by patients. For some participants, additional brain imaging (MRI without contrast, EEG, MEG) may be offered optionally to identify neural correlates of cognitive deficits.",[9],null,{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Brain MRI (optional)","Brain MRI without contrast perform at one visit to identify neural correlates of cognitive deficits",[9],{"type":19,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Electroencephalography (optional)","Electroencephalography performed at one visit",[9],{"type":19,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"Magnetoencephalography (optional)","Magnetoencephalography performed at one visit",[9],[36],{"name":37,"affiliation":38,"role":39},"Pierre BOURDILLON, Dr","Hôpital Fondation Adolphe de Rothschild","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":22,"email":45},"Jacob DHOTE, Dr","CONTACT","+33 145658177","j.dhote@ghu-paris.fr",{"name":47,"role":43,"phone":22,"phoneExt":22,"email":48},"Fabien VINCKIER, Pr","F.VINCKIER@ghu-paris.fr",[50,69,79],{"facility":51,"status":52,"city":53,"state":22,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Departement of Adult Psychiatry, GH Pitié Salpétrière","RECRUITING","Paris","75013","France","FR",{"type":58,"coordinates":59},"Point",[60,61],2.3488,48.85341,{"lat":61,"lon":60},[64],{"name":65,"role":43,"phone":66,"phoneExt":67,"email":68},"Philippe FOSSATI, Pr","0142162870","+33","philippe.fossati@aphp.fr",{"facility":70,"status":52,"city":53,"state":22,"zip":71,"country":55,"countryCode":56,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences","75014",{"type":58,"coordinates":73},[60,61],{"lat":61,"lon":60},[76,78],{"name":42,"role":43,"phone":77,"phoneExt":22,"email":45},"33 + 0145658177",{"name":47,"role":43,"phone":22,"phoneExt":22,"email":48},{"facility":38,"status":80,"city":53,"state":22,"zip":22,"country":55,"countryCode":56,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"NOT_YET_RECRUITING",{"type":58,"coordinates":82},[60,61],{"lat":61,"lon":60},[85],{"name":37,"role":43,"phone":22,"phoneExt":22,"email":22},{"type":87,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[89],{"name":90,"class":91},"Institut du Cerveau et de la Moelle (ICM Institute)","UNKNOWN","100615672","characterization-of-high-level-cognitive-impairments-in-patients-with-neuropsychiatric-disorders-100615672",false,"NCT07295652","Characterization of High-Level Cognitive Impairments in Patients With Neuropsychiatric Disorders","Characterization of High-level Cognitive Impairments in Patients With Neuropsychiatric Disorders","COGPSY","Inclusion Criteria:\n\nFor patients:\n\n* Aged over 18 years\n* Diagnosed with a psychiatric disorder according to ICD-10 by a psychiatrist (F10-F98) or diagnosed with a neurological disorder according to ICD-10 by a neurologist (G00-G99)\n* Provided written informed consent\n* Affiliated with a social security scheme\n\nFor healthy volunteers:\n\n* Aged over 18 years\n* Provided written informed consent\n* Affiliated with a social security scheme\n\nExclusion Criteria:\n\nFor healthy volunteers:\n\n* Current diagnosis of a psychiatric disorder according to ICD-10 (F20-F98) or current prescription of a psychotropic medication, or diagnosis of a neurological disorder according to ICD-10 (G00-G99)\n* History of depression (F32)\n* Substance use disorder (excluding tobacco)\n* Neurological history (e.g., stroke, coma, epilepsy, neuroinflammatory or neurodegenerative disease) or identified cognitive disorder\n* Inability to complete cognitive testing (e.g., due to motor or sensory impairment)\n\nFor participants undergoing MRI (without contrast agent):\n\n* Presence of MRI contraindications: non-MRI-compatible pacemaker, heart valve, implant, or metallic foreign body\n* Pregnancy at the time of MRI",true,"ALL","18 Years",{"count":104,"type":105},600,"ESTIMATED","INTERVENTIONAL",[108],"NA","Neuropsychiatric disorders are extremely common, severe, and disabling conditions. In the field of psychiatry, they notably include schizophrenia, mood disorders (depressive and bipolar disorders), autism spectrum or neurodevelopmental disorders, obsessive-compulsive disorder, eating disorders, and personality disorders. In the field of neurology, one can cite neurodegenerative diseases (such as Alzheimer's disease, but also frontotemporal dementia or Parkinson's disease, which often represent frequent and challenging differential diagnoses of psychiatric disorders), focal neurological lesions (notably strokes and tumors), or epilepsy.\n\nCognitive impairments are present in nearly all neuropsychiatric disorders and contribute significantly to disability.\n\nWhile impairments in working memory and attention, executive functions, and social cognition have been relatively well studied, other cognitive domains remain largely unexplored in these populations. This is particularly the case for various aspects of motivation, metacognition, conscious access, or causal (Bayesian) inference.\n\nAlthough these domains likely play an important role in prognosis, no consensus currently exists regarding the methods for evaluating these functions.\n\nThe main objective of this study is to define a multidimensional, transdiagnostic atlas of high-level cognitive impairments-both specific and shared-across severe psychiatric disorders (notably schizophrenia, depressive disorder, bipolar disorder, autism spectrum or neurodevelopmental disorders, and obsessive-compulsive disorder) and neurological disorders (notably neurodegenerative diseases, focal neurological lesions, and epilepsy), by comparing them to healthy volunteers.\n\nThe investigators also aim to investigate the progression of cognitive impairments over time, across different phases of illness (symptom stabilization or exacerbation) or therapeutic intervention, through longitudinal follow-up of patients being monitored within the recruiting center.\n\nFinally, in a more exploratory manner, the investigators aim to investigate the neural correlates of the identified cognitive impairments.",[111,112,113,114],"Neurologic Disorders","Schizophrenia","Bipolar Disorder (BD)","Depressive Disorder",[116,117,118,119,120,121,122,123,124,125],"Cognitive dysfunction","Executive function","Metacognition","Motivation","Social cognition","Transdiagnostic approach","High-level cognition","Longitudinal cognitive changes","Cognitive profiling","Differential diagnosis","2025-12-16",{"date":128,"type":129},"2025-12-19","ACTUAL",{"date":131,"type":129},"2024-03-12",{"date":133,"type":105},"2039-03",{"name":5,"class":6},3]