[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634170":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":37,"collaborators":10,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":10,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"University of Chile","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy gingiva",null,"Adults without gingival inflammation diagnosed by a clinical exam",{"label":13,"type":10,"description":14,"interventionNames":10},"Periodontits","Adults with periodontitis diagnosed by a clinical exam",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Nicolas Dutzan, DDS, PhD","CONTACT","+56934037995","ndutzan@uchile.cl",[22],{"facility":23,"status":24,"city":25,"state":26,"zip":10,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Faculty of Dentistry, University of Chile","RECRUITING","Santiago","Metropolitan Region","Chile","CL",{"type":30,"coordinates":31},"Point",[32,33],-70.64827,-33.45694,{"lat":33,"lon":32},[36],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":38,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100634170","characterization-of-jak1-and-jak2-activation-in-gingival-tissues-during-homeostasis-and-periodontitis-100634170",false,"NCT07536204","Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis","Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets","Inclusion Criteria:\n\n* Adults\n* Sistemically healthy\n\nExclusion Criteria:\n\n* Active Maliganancy\n* History of radiation to the head-neck region\n* Chemotherapy or radiation within the last 5 years\n* History of hepatitis B\u002FC or HIV infection\n* Autoimmune diseases\n* Diagnosis of diabetes\n* Pregnancy or lactation\n* More than 3 hospitalizations over the last 3 years\n* Use of systemic antibiotics over the last 3 months\n* Use of systemic corticosteroids or immunosuppressants over the last 3 months\n* Use of cytokine therapy over the last 3 months\n* Use of large doses of pre\u002Fprobiotic supplements over the last 3 months\n* Smoke more than 10 cigarettes per day",true,"ALL","18 Years",{"count":50,"type":51},30,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to examine JAK1\u002F2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is:\n\nIs the JAK1\u002F2 pathway overactivated in periodontitis compared to health?\n\nParticipants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1\u002F2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.",[55,56,57,58,59],"Periodontitis","Periodontal Diseases","Periodontal Inflammation","Gingival Diseases","Periodontal Attachment Loss",[61,62,55,63,64],"JAK1","JAK2","Gingiva","Inflammation","2026-04-10",{"date":67,"type":68},"2026-04-17","ACTUAL",{"date":70,"type":68},"2023-06-01",{"date":72,"type":51},"2027-03-31",{"name":5,"class":6},1]