[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100356441":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":56,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":10,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Southern California","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ancillary-correlative (next generation sequencing)",null,"Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for RNA-based next generation sequencing of TCRA and TCRB genes.",[13,14],"Procedure: Biospecimen Collection","Other: Laboratory Biomarker Analysis",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"PROCEDURE","Biospecimen Collection","Undergo collection of blood samples",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Laboratory Biomarker Analysis","Correlative studies",[9],[26],{"name":27,"affiliation":5,"role":28},"Houda Alachkar, PharmD, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Christine Duran","CONTACT","323-865-0371","Duran_C@med.usc.edu",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"USC \u002F Norris Comprehensive Cancer Center","RECRUITING","Los Angeles","California","90033","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-118.24368,34.05223,{"lat":48,"lon":47},[51,55],{"name":52,"role":32,"phone":53,"phoneExt":10,"email":54},"Houda Alachkar","323-442-2696","alachkar@usc.edu",{"name":52,"role":28,"phone":10,"phoneExt":10,"email":10},{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[59],{"name":60,"class":61},"National Cancer Institute (NCI)","NIH","100356441","characterization-of-t-cell-repertoire-in-patients-with-acute-myeloid-leukemia-undergoing-donor-stem-cell-transplant-100356441",false,"NCT03921047","Characterization of T-cell Repertoire in Patients With Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant","Characterization of T-cell Repertoire in Patients With AML Undergoing HSCT Through Next-Generation Sequencing of T Cell Receptor Alpha (TCRA) and T Cell Receptor Beta (TCRB) Genes","Inclusion Criteria:\n\n* Diagnosis of AML scheduled to undergo HSCT at University of Southern California (USC)\n\nExclusion Criteria:\n\n* Inability to provide consent because of severe mental disorders\n* Donor unwilling to provide consent","ALL","18 Years",{"count":72,"type":73},250,"ESTIMATED","OBSERVATIONAL","This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.",[77],"Acute Myeloid Leukemia","2026-05-29",{"date":80,"type":81},"2026-06-03","ACTUAL",{"date":83,"type":81},"2018-04-12",{"date":85,"type":73},"2027-12-31",{"name":5,"class":6},1]