[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555730":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":36,"locations":45,"responsibleParty":63,"collaborators":10,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":68,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":84,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Dental implants",null,"Intra-oral photograph\n\nSample of Peri-implant Crevicular fluid\n\nClinical Examination\n\nPeri-apical x-ray",[13,14],"Diagnostic Test: Clinical Examination","Procedure: Peri-implant crevicular fluid",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Clinical Examination","Clinical examination of a dental implant",[9],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"PROCEDURE","Peri-implant crevicular fluid","Collection of a sample of peri-implant crevicular fluid",[9],[27,31,34],{"name":28,"affiliation":29,"role":30},"Heba Allah Madi Dr","McGill University","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":29,"role":33},"Nicholas Makhoul Dr","STUDY_DIRECTOR",{"name":35,"affiliation":29,"role":33},"Jocelyne Feine Dr",[37,41],{"name":28,"role":38,"phone":39,"phoneExt":10,"email":40},"CONTACT","+14383344777","heba.madi@mail.mcgill.ca",{"name":32,"role":38,"phone":42,"phoneExt":43,"email":44},"+15149341934","42492","nicholas.makhoul@muhc.mcgill.ca",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Montreal General Hospital - Oral & Maxillofacial Surgery Clinic","RECRUITING","Montreal","Quebec","H3G 1A4","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-73.58781,45.50884,{"lat":58,"lon":57},[61,62],{"name":28,"role":38,"phone":39,"phoneExt":10,"email":40},{"name":28,"role":30,"phone":10,"phoneExt":10,"email":10},{"type":30,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Nicholas Makhoul","Associate professor and Associate Dean of Post-Graduate Dental Education","100555730","characterizing-the-inflammation-around-dental-implants-bacterial-infection-hypersensitivity-or-both-100555730",false,"NCT06515886","Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?","Inclusion Criteria:\n\n* Received at least one functional implant (implant restored with a prothesis);\n* Did not receive peri-implant mucositis and peri-implantitis treatment in the past three months.\n\nExclusion criteria:\n\n* Dental records with incomplete information;\n* Individuals with a weak immune system or chronic disease such as diabetes, heart, lung or kidney disease;\n* Pregnant women;\n* Individuals undergoing orthodontic therapy and those who have oral piercing.\n* History of diseases that modify or suppress the immune and inflammatory response, including rheumatoid arthritis, diabetes, lupus, and inflammatory bowel disease and metastatic cancer;\n* Taking medications that cause antiresorptive osteonecrosis of the jaw (including any dose of intravenous bisphosphonates, oral bisphosphonate intake for more than three years, receptor activator of nuclear factor kappa-B ligand inhibitors, or antiangiogenic medications);\n* Taking medications known to induce gingival hyperplasia including anticonvulsants, immunosuppressants, or calcium channel blockers;\n* Taking steroid medications, systemic or local antibiotics in the last three months (as this may affect the interleukins activity);\n* Received radiation therapy to the head and neck or chemotherapy;\n* Received treatment to manage an inflamed implant, including management of peri-implantitis and peri-implant mucositis in the last three months.","ALL","18 Years",{"count":75,"type":76},40,"ESTIMATED","OBSERVATIONAL","The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs. The current study will investigate if the inflammation around the implant is due to bacterial infection, hypersensitivity or both.",[80,81,82,83],"Dental Implant Failed","Implant Complication","Implant Site Infection","Implant Site Reaction",[85,86,87,88,89,90],"Dental implant","Peri-implant inflammation","Inflammatory mediators","Bacterial infection","Hypersensitivity","peri-implantitis","2024-07-19",{"date":93,"type":94},"2024-07-23","ACTUAL",{"date":96,"type":94},"2022-09-22",{"date":98,"type":76},"2025-12-01",{"name":5,"class":6},1]