[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481197":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":54,"centralContacts":59,"locations":65,"responsibleParty":84,"collaborators":39,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":39,"eligibilityCriteria":92,"healthyVolunteers":93,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":39,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":39,"overallStatus":68,"whyStopped":39,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University of California, Davis","OTHER",[8,16,23,27,31],{"label":9,"type":10,"description":11,"interventionNames":12},"Low Flavanol Cocoa Powder","PLACEBO_COMPARATOR","12 g of Low Flavanol Cocoa Powder (30 mg of cocoa flavanols) provided as a beverage mixed in water",[13,14,15],"Other: High Flavanol Cocoa Powder","Other: Vine to Bar Chocolate - 2 servings","Other: Vine to Bar Chocolate - 1 serving",{"label":17,"type":18,"description":19,"interventionNames":20},"High Flavanol Cocoa Powder","EXPERIMENTAL","High Flavanol Cocoa Powder (435 mg of flavanols) will be provided as a beverage mixed in water.",[21,14,15,22],"Other: Low Flavanol Cocoa Powder","Other: Vine to Bar Chocolate covered almonds",{"label":24,"type":18,"description":25,"interventionNames":26},"Two Servings of Vine to Bar Chocolate","Two servings (60g, 6 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.",[15,22],{"label":28,"type":18,"description":29,"interventionNames":30},"One Serving of Vine to Bar Chocolate","A single serving (30g, 3 pieces) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc.",[21,13,14,22],{"label":32,"type":18,"description":33,"interventionNames":34},"Vine to Bar Chocolate covered Almonds","11 pieces (45g) of Vine to Bar Chocolate providing both cocoa flavanols and Chardonnay marc, with almonds",[14,15],[36,40,43,47,50],{"type":6,"name":9,"description":37,"armGroupLabels":38,"otherNames":39},"Measure the response 2 and 6 hours post low flavanol cocoa intake",[17,28],null,{"type":6,"name":17,"description":41,"armGroupLabels":42,"otherNames":39},"Measure the response 2 and 6 hours post high flavanol cocoa intake",[9,28],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":39},"Vine to Bar Chocolate - 2 servings","Measure the response 2 and 6 hours post chocolate intake",[17,9,28,32],{"type":6,"name":48,"description":45,"armGroupLabels":49,"otherNames":39},"Vine to Bar Chocolate - 1 serving",[17,9,24,32],{"type":6,"name":51,"description":52,"armGroupLabels":53,"otherNames":39},"Vine to Bar Chocolate covered almonds","Measure the response 2 and 6 hours post chocolate covered almond intake",[17,28,24],[55],{"name":56,"affiliation":57,"role":58},"Carl L Keen","Distinguished Professor Emeritus of Nutrition","PRINCIPAL_INVESTIGATOR",[60],{"name":61,"role":62,"phone":63,"phoneExt":39,"email":64},"Roberta R Holt","CONTACT","5304005952","rrholt@ucdavis.edu",[66],{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":72,"countryCode":73,"cosmosGeoPoint":74,"geoPoint":79,"contacts":80},"Academic Surge, University of California, Davis","RECRUITING","Davis","California","95616","United States","US",{"type":75,"coordinates":76},"Point",[77,78],-121.74052,38.54491,{"lat":78,"lon":77},[81],{"name":82,"role":62,"phone":83,"phoneExt":39,"email":64},"Roberta R Holt, PhD","530-400-5952",{"type":85,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR","100481197","chardonnay-marc-and-vascular-response-100481197",false,"NCT05545865","Chardonnay Marc and Vascular Response","Preclinical Trials to Determine the Range of Chardonnay Mark Intake for Improved Metabolic and Vascular Response.","Inclusion Criteria:\n\n* Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) \\\u003C 2.0\n* Subject is willing and able to comply with the study protocols.\n* Subject is willing to participate in all study procedures\n* BMI 25.0 - 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* BMI ≥ 35 kg\u002Fm2\n* Indivduals that weight less than a 110 lbs\n* Donation of blood within the previous 30 days\n* Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0\n* 1 ug\u002Fml and 3 ug\u002Fml collagen screening maximal platelet aggregatory response of \\\u003C 65%.\n* Platelet counts \\\u003C 150,000 \u002F ul\n* Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.\n* Dislike or allergy for nuts, cocoa or grape products\n* Self-reported use of daily anticoagulation agents including aspirin, NSAIDs\n* Vegan, Vegetarians, food faddists or those consuming a non-traditional diet\n* Fruit consumption ≥ 3 cups\u002Fday\n* Vegetable consumption ≥ 4 cups\u002Fday\n* Nut intake ≥ 2 servings\u002F week\n* Coffee\u002Ftea ≥ 3 cups\u002Fday\n* Dark chocolate ≥ 3 oz\u002Fday\n* Self-reported restriction of physical activity due to a chronic health condition\n* Self-reported chronic\u002Froutine high intensity exercise\n* Self-reported diabetes\n* Blood pressure ≥ 140\u002F90 mm Hg\n* Self-reported renal or liver disease\n* Self-reported heart disease, which includes cardiovascular events and stroke\n* Peripheral artery disease, Raynaud's syndrome\n* Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT\n* Self-reported cancer within past 5 years\n* Self-reported malabsorption\n* Currently taking prescription drugs or supplements.\n* Supplement use or unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.\n* Indications of substance or alcohol abuse within the last 3 years\n* smoking, vaping, cannabis use\n* Current enrollee in a clinical research study.",true,"MALE","30 Years","50 Years",{"count":98,"type":99},5,"ESTIMATED","INTERVENTIONAL",[102],"NA","This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes\u002Fbiomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.",[105,106,107],"Cardiovascular Diseases","Vascular Dilation","Oxidative Stress","2026-02-13",{"date":110,"type":111},"2026-02-18","ACTUAL",{"date":113,"type":111},"2022-09-01",{"date":115,"type":99},"2026-08-24",{"name":5,"class":6},1]