[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644237":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":50,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":26,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University of Electronic Science and Technology of China","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Motivational Interviewing-based AI chatbot group","EXPERIMENTAL","Motivational Interviewing-based AI chatbot intervention",[13],"Behavioral: MI Chatbot Interaction",{"label":15,"type":16,"description":17,"interventionNames":18},"Active control chatbot group","ACTIVE_COMPARATOR","Active control nature-story chatbot intervention",[19],"Behavioral: Active Control Chatbot Interaction",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","MI Chatbot Interaction","The experimental chatbot is designed to use principles of Motivational Interviewing to support participants in exploring their personal values, motivation for change, and daily behavioral goals related to pleasure, engagement, and reward-seeking. During the intervention period, participants will interact with the chatbot regularly through brief text-based conversations. The chatbot will provide empathic, non-judgmental responses, encourage reflection on current difficulties, and help participants identify small, feasible actions that may increase daily engagement and positive experiences. It will not provide diagnosis, crisis counseling, or medical treatment.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Active Control Chatbot Interaction","Participants will interact with a chatbot matched in format and frequency of use. This chatbot will provide neutral nature-related stories or general natural history content. It will be designed to maintain participant engagement while avoiding therapeutic techniques, motivational interviewing strategies, behavioral activation guidance, or personalized mental health advice. This active control condition will help control for nonspecific effects of chatbot interaction, attention, expectancy, and digital engagement.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Benjamin Becker, Dr","CONTACT","(852) 3917-5097","bbecker@hku.hk",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":26,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":26},"RECRUITING","Chengdu","Sichuan","China","CN",{"type":45,"coordinates":46},"Point",[47,48],104.06667,30.66667,{"lat":48,"lon":47},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Benjamin Becker","Professor","100644237","chatbot-intervention-effects-on-social-and-monetary-incentive-processing-in-anhedonia-100644237",false,"NCT07665242","Chatbot Intervention Effects on Social and Monetary Incentive Processing in Anhedonia","Effects of a Chatbot-Based Intervention on Behavioral Responsiveness and Neural Anticipation of Social and Monetary Incentives in Individuals With Anhedonia","Inclusion Criteria:\n\n* 18-40 years\n* Right-handed\n* Normal or corrected normal visual acuity\n* Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 23.5 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory\n\nExclusion Criteria:\n\n* History of major central nervous system disorders, such as epilepsy, traumatic brain injury, stroke, or brain tumors.\n* History of severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, or other psychotic disorders.\n* History of substance or alcohol use disorder or substance or alcohol misuse within the past 12 months that may affect study participation or outcome assessment.\n* Individuals currently at high risk of suicide, severe self-harm, or experiencing an acute psychiatric crisis.\n* Individuals who are currently using psychiatric medications or have undergone psychotherapy within the past 4 weeks that may significantly affect mood, motivation, or reward processing.\n* Severe vision or hearing impairments that cannot be corrected and would interfere with task performance.\n* Contraindications to MRI scanning, including metallic implants, pacemakers, severe claustrophobia, or other conditions incompatible with MRI.\n* Pregnancy or breastfeeding.",true,"ALL","18 Years","40 Years",{"count":66,"type":67},80,"ESTIMATED","INTERVENTIONAL",[70],"NA","The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on social incentive processing in college students with elevated levels of depression and anhedonia by combining a randomized active-control intervention design with pre- and post-intervention Social Incentive Delay Task assessments during fMRI.",[73],"Healthy",[75,76],"fMRI","AI Interaction","2026-06-22",{"date":79,"type":80},"2026-06-24","ACTUAL",{"date":82,"type":67},"2026-06-20",{"date":84,"type":67},"2028-12-31",{"name":5,"class":6},1]