[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100283653":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":43,"locations":52,"responsibleParty":106,"collaborators":108,"id":116,"slug":117,"hasResults":118,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":118,"sex":124,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":47,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":54,"whyStopped":47,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"The First Affiliated Hospital of Henan University of Science and Technology","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CRT group","ACTIVE_COMPARATOR","3-weekly cycles of cisplatin and 5-fluorouracil chemotherapy and radical radiotherapy delivered in IMRT mode (total of 50Gy given in 25 fractions) will be given over a period 5-6 weeks.",[13],"Procedure: CRT",{"label":15,"type":10,"description":16,"interventionNames":17},"Surgery group","The patients randomized to receive either standard esophagectomy will have the operation performed in an open manner with two-field lymphadenectomy",[18],"Procedure: surgery",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","CRT","Drug: Capecitabine(Aibin) capecitabine(Aibin)：625mg\u002Fm2, bid d1-5; q1w, po,5 weeks in total\n\nOther Names:\n\nAibin Drug: Oxaliplatin(Aiheng) Oxaliplatin(Aiheng)：65mg\u002Fm2，d1，8, 22, 29,I.V.\n\nOther Names:\n\nAiheng cisplatin: 75mg\u002Fm2 d1，29 or d1, 29, 57, 85. 5-Fu：750mg\u002Fm2 CIV24h d1-4，d29-32 or d1-4，d29-32, d57-60, d85-88.\n\nRadiation: Radiotherapy concurrent radiotherapy：IMRT radiotherapy 50Gy in total，2 Gy\u002Fd，5d\u002Fw，Until disease progression or unacceptable toxicity",[9],[26],"concurrent chemoradiotherapy",{"type":21,"name":28,"description":16,"armGroupLabels":29,"otherNames":30},"surgery",[15],[31],"esophagectomy",[33,37,40],{"name":34,"affiliation":35,"role":36},"Shegan Gao, MD, PhD","The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology","STUDY_CHAIR",{"name":38,"affiliation":39,"role":36},"Fuyou Zhou, MD, PhD","Anyang Tumor Hospital",{"name":41,"affiliation":35,"role":42},"Ruinuo Jia, MD","PRINCIPAL_INVESTIGATOR",[44,49],{"name":34,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","+86 18638859977",null,"gsg112258@163.com",{"name":41,"role":45,"phone":50,"phoneExt":47,"email":51},"+86 18537950766","jiaruinuo@163.com",[53,69],{"facility":39,"status":54,"city":55,"state":56,"zip":47,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Anyang","Henan","China","CN",{"type":60,"coordinates":61},"Point",[62,63],114.38278,36.096,{"lat":63,"lon":62},[66],{"name":67,"role":45,"phone":68,"phoneExt":47,"email":51},"Fuyou Zhou, MD,PhD","+86 13939998799",{"facility":35,"status":54,"city":70,"state":56,"zip":71,"country":57,"countryCode":58,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Luoyang","471003",{"type":60,"coordinates":73},[74,75],112.43684,34.67345,{"lat":75,"lon":74},[78,79,80,81,84,86,88,90,92,94,96,98,100,102,104],{"name":34,"role":45,"phone":46,"phoneExt":47,"email":48},{"name":41,"role":45,"phone":50,"phoneExt":47,"email":51},{"name":41,"role":42,"phone":47,"phoneExt":47,"email":47},{"name":82,"role":83,"phone":47,"phoneExt":47,"email":47},"Xinshuai Wang, MD, PhD","SUB_INVESTIGATOR",{"name":85,"role":83,"phone":47,"phoneExt":47,"email":47},"Guoqiang Kong, MD",{"name":87,"role":83,"phone":47,"phoneExt":47,"email":47},"Baoping Chang, MD, PhD",{"name":89,"role":83,"phone":47,"phoneExt":47,"email":47},"Jiachun Sun, MD, PhD",{"name":91,"role":83,"phone":47,"phoneExt":47,"email":47},"Xiaozhi Yuan, MD",{"name":93,"role":83,"phone":47,"phoneExt":47,"email":47},"Dan Zhou, MD",{"name":95,"role":83,"phone":47,"phoneExt":47,"email":47},"Ruina Yang, MD",{"name":97,"role":83,"phone":47,"phoneExt":47,"email":47},"Jing Ren, MD",{"name":99,"role":83,"phone":47,"phoneExt":47,"email":47},"Shuoguo Li, MD",{"name":101,"role":83,"phone":47,"phoneExt":47,"email":47},"Wei Wang, MD",{"name":103,"role":83,"phone":47,"phoneExt":47,"email":47},"Shiyuan Song, MD",{"name":105,"role":83,"phone":47,"phoneExt":47,"email":47},"Weijiao Yin, MD",{"type":107,"investigatorFullName":47,"investigatorTitle":47,"investigatorAffiliation":47,"oldNameTitle":47,"oldOrganization":47},"SPONSOR",[109,112,113],{"name":110,"class":111},"Jiangsu HengRui Medicine Co., Ltd.","INDUSTRY",{"name":39,"class":6},{"name":114,"class":115},"150th Hospital of PLA","OTHER_GOV","100283653","chemoradiation-versus-esophagectomy-for-locally-advanced-esophageal-cancer-100283653",false,"NCT02972372","Chemoradiation Versus Esophagectomy for Locally Advanced Esophageal Cancer","A Randomized, Open-label, Multicenter Trial of the Chemoradiation Versus Standard Esophagectomy for Locally Advanced Resectable Esophageal Squamous Cell Cancer in Chinese Patients","CELAEC","Inclusion Criteria:\n\n* Chinese\n* esophageal squamous cell cancer\n* mid or lower esophageal cancer\n* tumor is resectable disease\n* clinical stage: cT1bN+Mo, or cT2-4aN0-2M0\n\nExclusion Criteria:\n\n* who had distant metastasis to solid visceral organs or local invasion into trachea, descending aorta, or recurrent laryngeal nerve.\n* who had a serious premorbid condition or a poor physical status that compromised a thoracotomy.","ALL","18 Years","75 Years",{"count":128,"type":129},196,"ESTIMATED","INTERVENTIONAL",[132],"NA","The aim of this study is to compare outcomes in Chinese patients with locally advanced resectable esophageal squamous cell cancer who have received either surgery or definitive chemoradiation (CRT) by the randomized, open-label, multicenter trial.",[135],"Esophagus Cancer",[137,138,31],"esophageal cancer","chemoradiation","2025-02-06",{"date":141,"type":142},"2025-02-10","ACTUAL",{"date":144,"type":142},"2016-11",{"date":146,"type":129},"2027-12",{"name":5,"class":6},2]