[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100449230":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":60,"collaborators":11,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":11,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":11,"overallStatus":83,"whyStopped":11,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Qilu Hospital of Shandong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"radical surgery with PALND","EXPERIMENTAL",null,[13],"Procedure: Radical surgery with PALND",{"label":15,"type":16,"description":11,"interventionNames":17},"radical surgery without PALND","ACTIVE_COMPARATOR",[18],"Procedure: Radical surgery without PALND",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Radical surgery with PALND","sufficient resection margins of the tumor, D3 dissection of the regional lymph nodes and para-aortic lymph node dissection from the bifurcation of iliac artery to the left renal vein via laparoscopic approach",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Radical surgery without PALND","surgery includes sufficient resection margins of the tumor and D3 dissection of the regional lymph nodes without PALND",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Yong Dai, M.D. Ph.D.","CONTACT","+8618560085117","yongdai@hotmail.com",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"Xiang Zhang, M.D. Ph.D.","+8618560089182","xiang.zhang02@hotmail.com",[40],{"facility":5,"status":11,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Jinan","Shandong","250012","China","CN",{"type":47,"coordinates":48},"Point",[49,50],116.99722,36.66833,{"lat":50,"lon":49},[53,56],{"name":54,"role":32,"phone":55,"phoneExt":11,"email":38},"Xiang Zhang","18560089182",{"name":57,"role":32,"phone":58,"phoneExt":11,"email":59},"Yanlei Wang","18560085128","yanleiwang@hotmail.com",{"type":61,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100449230","chemoradiotherapy-sequenced-radical-surgery-for-colorectal-cancer-with-palnm-100449230",false,"NCT05129774","Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM","Concurrent Chemoradiotherapy Sequenced Radical Surgery for Para-aortic Lymph Node Metastasis of Left-sided Colon and Rectal Cancer","Inclusion Criteria:\n\n* age at enrollment is ≥ 18 and ≤ 75 years\n* ECOG PS 0-1\n* histologically confirmed left-sided colon and rectal carcinoma\n* synchronous para-aortic lymph node metastases confirmed by PET-CT, and located below the level of renal veins and above the bifurcation of iliac artery\n* patients potential to receive surgery and achieve no evidence of disease (NED)\n* able to tolerate surgery\n* providing written informed consent\n\nExclusion Criteria:\n\n* local invasion or distant metastasis other than para-aoritc lymph nodes\n* history of other malignant tumor\n* coupled with severe systematic diseases (recent myocardial infarction, cardiomyopathy, or acute pulmonary infection)\n* emergency surgery","ALL","18 Years","70 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%. Currently, there has been no standard treatment strategy for this situation. The present trial is designed to evaluate the safety and efficacy of para-aortic lymph node dissection for left-sided colon and rectal cancer with synchronous para-aortic lymph node metastasis",[80,81,82],"Colorectal Neoplasms Malignant","Lymph Node Excision","Chemoradiotherapy","NOT_YET_RECRUITING","2021-11-18",{"date":86,"type":87},"2021-11-22","ACTUAL",{"date":89,"type":74},"2022-01-01",{"date":91,"type":74},"2027-01-01",{"name":5,"class":6},1]