[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537128":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":32,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":18,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":34,"whyStopped":18,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The Netherlands Cancer Institute","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Blood sample","Collection of serum blood sample at day of start neo adjuvant treatment",[12],"Procedure: Blood sample",[14],{"type":15,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"PROCEDURE","Collection of serum sample at the day of start of neo adjuvant treatment",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Sabine Linn, MD","Antoni van Leeuwenhoek","PRINCIPAL_INVESTIGATOR",[25,29],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},"CONTACT","+31205129111","s.linn@nki.nl",{"name":30,"role":26,"phone":18,"phoneExt":18,"email":31},"Ingrid Mandjes","i.mandjes@nki.nl",[33],{"facility":22,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Amsterdam","North Holland","1066CX","Netherlands","NL",{"type":41,"coordinates":42},"Point",[43,44],4.88969,52.37403,{"lat":44,"lon":43},[47,51,52],{"name":48,"role":26,"phone":49,"phoneExt":18,"email":50},"Sarah Pruckl, PhD","0205129111","chemosense@nki.nl",{"name":30,"role":26,"phone":18,"phoneExt":18,"email":31},{"name":21,"role":23,"phone":18,"phoneExt":18,"email":18},{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100537128","chemosensitivity-during-phases-of-the-menstrual-cycle-in-breast-cancer-patients-100537128",false,"NCT06273800","Chemosensitivity During Phases of the Menstrual Cycle in Breast Cancer Patients","Chemosense","Inclusion Criteria:\n\n* Women with a new diagnosis of triple negative breast cancer who have not yet started systemic treatment.\n* Patients with stage I-III disease, patient with locoregional recurrence who have not been treated with chemotherapy before. ,\n* Aged \\\u003C 60 years\n* Women having a (regular) physiological menstrual cycle\n* Patients who are assigned to receive neoadjuvant chemotherapy with or without immunotherapy, targeted therapy and endocrine therapy\n* Patients must be systemic treatment naïve for current malignancy (e.g. no chemotherapy, hormonal therapy or targeted therapy)\n* Signed written informed consent\n\nExclusion Criteria:\n\n* current use of hormonal contraception or in the six weeks prior to start of neoadjuvant systemic treatment for breast cancer, such as:\n* Oral contraception (OAC)\n* Hormonal intra-uterine device (IUD, Mirena)\n* No ovarian function suppression to preserve fertility\n* Other forms of hormonal contraception, including but not limited to: nuva-ring, Implanon, prikpil\n* Currently pregnant and \u002F or breast feeding. In case of use of hormonal contraception or breast feeding in de last year: patients should have had at least 2 menstrual cycles since stopping hormonal contraception.\n\n  \\- active other malignancy\n* IVF-trajectory for egg cell preservation prior to start of neoadjuvant systemic treatment","FEMALE","18 Years","59 Years",{"count":66,"type":67},100,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study is a prospective, multicenter study in which a serum sample will be collected at the day of starting neo adjuvant treatment in breast cancer patients",[73],"Breast Cancer",[75,76,77,78],"Triple negative tumor","Stage I - III disease","Starting neo adjuvant treatment","Regular physiological menstrual cycle (premenopausal)","2025-11-21",{"date":81,"type":82},"2025-11-26","ACTUAL",{"date":84,"type":82},"2025-10-14",{"date":86,"type":67},"2036-07-15",{"name":5,"class":6},1]