[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548941":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":111,"collaborators":18,"id":115,"slug":116,"hasResults":117,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":117,"sex":122,"minAge":123,"maxAge":18,"enrollmentInfo":124,"targetDuration":18,"studyType":127,"phases":128,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":148},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Saline Intervention Arm","EXPERIMENTAL","Patient will receive 20 mL sterile saline flushes into their catheter by study team members every 6 ± 2 hours. If patients are receiving intrapleural tissue plasminogen activator and deoxyribonuclease therapy, each treatment will be considered one flush.",[13],"Other: Saline Flush",{"label":15,"type":16,"description":17,"interventionNames":18},"No Intervention Arm","NO_INTERVENTION","Patient will receive a saline flush as needed, to restore patency of a chest tube considered blocked. No routine flushes will be administered.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Saline Flush","sterile saline 20 mL flushed into their catheter by trained nurses or study team members every 6 ± 2 hours",[9],[25],{"name":26,"affiliation":27,"role":28},"Jennifer D Duke, MD","Vanderbilt University","STUDY_DIRECTOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Samira Shojaee, MD, MPH","CONTACT","615-322-2386","samira.shojaee@vumc.org",{"name":36,"role":32,"phone":33,"phoneExt":18,"email":37},"Jennifer Duke, MD","jennifer.duke@vumc.org",[39,58,73,87,96],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Henry Ford","RECRUITING","Sterling Heights","Michigan","48310","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-83.0302,42.58031,{"lat":51,"lon":50},[54],{"name":55,"role":32,"phone":56,"phoneExt":18,"email":57},"Labib Debiane, MD","800-436-7936","ldebian1@hfhs.org",{"facility":59,"status":41,"city":60,"state":61,"zip":62,"country":45,"countryCode":46,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Creighton University","Omaha","Nebraska","68124",{"type":48,"coordinates":64},[65,66],-95.94043,41.25626,{"lat":66,"lon":65},[69],{"name":70,"role":32,"phone":71,"phoneExt":18,"email":72},"Zachary S DePew, MD","402-717-9600","zachary.depew@commonspirit.org",{"facility":74,"status":41,"city":75,"state":75,"zip":76,"country":45,"countryCode":46,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Mount Sinai","New York","10029",{"type":48,"coordinates":78},[79,80],-74.00597,40.71427,{"lat":80,"lon":79},[83],{"name":84,"role":32,"phone":85,"phoneExt":18,"email":86},"Udit S Chaddha","212-241-5656","udit.chaddha@mssm.edu",{"facility":5,"status":41,"city":88,"state":89,"zip":90,"country":45,"countryCode":46,"cosmosGeoPoint":91,"geoPoint":95,"contacts":18},"Nashville","Tennessee","37203",{"type":48,"coordinates":92},[93,94],-86.78444,36.16589,{"lat":94,"lon":93},{"facility":97,"status":41,"city":98,"state":99,"zip":100,"country":45,"countryCode":46,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Virginia Commonwealth University","Richmond","Virginia","23298",{"type":48,"coordinates":102},[103,104],-77.46026,37.55376,{"lat":104,"lon":103},[107],{"name":108,"role":32,"phone":109,"phoneExt":18,"email":110},"Danai Khemasuwan","804-828-6396","Danai.Khemasuwan@vcuhealth.org",{"type":112,"investigatorFullName":113,"investigatorTitle":114,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Samira Shojaee","Associate Professor of Medicine","100548941","chest-drain-regular-flushing-in-complicated-parapneumonic-effusions-and-empyemas-100548941",false,"NCT06427538","Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas","RELIEF","Inclusion Criteria:\n\n* Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy\n* Age \\> 18 years old.\n\nExclusion Criteria:\n\n* Patients who have surgical tubes that can't accommodate a three-way stopcock.\n* Study subject has any disease or condition that interferes with the safe completion of the study.\n* Inability to provide informed consent.\n* Inability to undergo a chest X-ray.\n* If the managing clinician believes the chest tube will be placed for less than 24 hours.\n* Patients with an indwelling pleural catheter (IPC)","ALL","18 Years",{"count":125,"type":126},96,"ESTIMATED","INTERVENTIONAL",[129],"NA","Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.",[132,133],"Empyema, Pleural","Pleural Infection",[135,136,137,138],"empyema","pleural infection","chest tube","saline flush","2026-02-18",{"date":141,"type":142},"2026-02-20","ACTUAL",{"date":144,"type":142},"2024-06-21",{"date":146,"type":126},"2026-12-30",{"name":5,"class":6},5]