[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457503":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":20,"locations":27,"responsibleParty":45,"collaborators":19,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":19,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":30,"whyStopped":19,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Hospital, Limoges","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"All patients","Metabolic, hormonal and psychometric evaluations will be carried out during or after hospitalization inflammatory parameters, hormonal, capillary, saliva and urine assays will also be carried out",[12],"Biological: Biological dosage",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"BIOLOGICAL","Biological dosage","Metabolic, hormonal and psychometric evaluations will be carried out during inclusion inflammatory parameters, hormonal, capillary, saliva and urine assays will also be carried out at inclusion",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Laurence SALLE, MD","CONTACT","555049818","+33","laurence.salle@chu-limoges.fr",[28],{"facility":29,"status":30,"city":31,"state":19,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"LimogesUniversity Hospital","RECRUITING","Limoges","87049","France","FR",{"type":36,"coordinates":37},"Point",[38,39],1.24759,45.83362,{"lat":39,"lon":38},[42,43],{"name":22,"role":23,"phone":19,"phoneExt":19,"email":26},{"name":22,"role":44,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"type":46,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100457503","childhood-traumas-in-obese-women-association-with-deregulation-of-the-glucocorticoid-axis-and-inflammatory-state-100457503",false,"NCT05237440","Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.","OBEVIE","Inclusion Criteria:\n\n* ≥18 years female BMI≥30kg\u002Fm2\n\nExclusion Criteria:\n\n1. History of bariatric surgery\n2. Any condition or pathology that may influence the corticotropic axis or that may modify the excretion or dosage of cortisol:\n\n   * pregnancy, breastfeeding\n   * hepatocellular insufficiency,\n   * severe heart failure,\n   * mild\u002Fmoderate acute heart failure,\n   * any psychological disorder not stabilised for at least one year\n   * alcohol or drug dependence, not weaned for at least one year\n   * neoplasm under treatment\n3. Current infectious disease or a history of autoimmune disease (except autoimmune hypothyroidism), inflammatory disease and\u002For neurodegenerative disease\n4. Presence of an adrenal adenoma or any known or suspected clinical adrenal or corticotropic disorder\n5. Subjects with a positive diagnosis of hypercorticism or suspected hypercorticism will also be excluded: 8-hour plasma cortisol after Dexamethasone suppression test (DST) (1 mg dexamethasone taken orally at midnight the previous day) greater than 1.8 microg\u002F100 ml (50 nmol\u002Fl)\n6. antidepressant and neuroleptic treatment, benzodiazepine treatment\n7. treatment(s) likely to modify the exploration of the corticotropic axis: systemic or local corticosteroid therapy or glucocorticoid infiltration for less than 6 months\n8. current use of anti-inflammatory drugs or antibiotics\n9. Shift worker","FEMALE","18 Years",{"count":57,"type":58},102,"ESTIMATED","INTERVENTIONAL",[61],"NA","We postulate that childhood traumas are associated with deregulation of the glucocorticoid axis and the inflammatory system in obese women. The main objective of the study is to compare the salivary cortisol awaking response in obese women according to the presence of childhood trauma (assessed using the Childhood Trauma Questionnaire, CTQ).",[64],"Obesity",[66,67,68,69,70],"obesity","childhood trauma","hypothalamic-pituitary-adrenal axis","inflammation","metabolic syndrome","2026-06-25",{"date":73,"type":74},"2026-06-26","ACTUAL",{"date":76,"type":74},"2022-04-13",{"date":78,"type":58},"2027-05-13",{"name":5,"class":6},1]