[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100518259":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":23,"collaborators":10,"id":27,"slug":28,"hasResults":29,"nctId":30,"briefTitle":31,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":29,"sex":35,"minAge":36,"maxAge":37,"enrollmentInfo":38,"targetDuration":10,"studyType":41,"phases":10,"briefSummary":42,"conditions":43,"keywords":10,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":10},{"fullName":5,"class":6},"Ruijin Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"survival group",null,"patients still survive at 28 days",[13],"Other: prognosis status",{"label":15,"type":10,"description":16,"interventionNames":17},"mortality group","patients die within 28 days",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"prognosis status","observatory; patients will be divided into survival group and mortality group according to their prognosis at day 28",[15,9],{"type":24,"investigatorFullName":25,"investigatorTitle":26,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jieming QU","Professor","100518259","chinese-hospital-acquired-pneumonia-collaboration-network-epidemiology-diagnosis-and-treatment-100518259",false,"NCT06028217","Chinese Hospital Acquired Pneumonia Collaboration Network: Epidemiology, Diagnosis and Treatment","A Prospective Study on Pathogen Investigation, Risk Factors, and Prognostic Factors Analysis of Hospital Acquired Pneumonia (HAP)","CHAPTER","Inclusion Criteria:\n\n1. Age ≥ 18 years old.\n2. Meets the clinical diagnostic criteria for HAP in the 2018 HAP\u002FVAP guidelines. Chest X-ray or CT shows new or progressive infiltrative shadows, consolidation shadows, or ground glass shadows, combined with 2 or more of the following 3 clinical symptoms, to establish a clinical diagnosis: 1) Fever, body temperature\\>38 ℃; 2) Purulent airway secretions; 3) Peripheral blood white blood cell count \\>10 × 10\\^9\u002FL or \\\u003C4 × 10\\^9\u002FL.\n3. Having qualified evidence of responsible pathogen. On the basis of clinical diagnosis, one of the following conditions should be met simultaneously: 1) Qualified lower respiratory tract secretions (neutrophil count \\>25\u002Flow magnification field, epithelial cell count \\\u003C10\u002Flow magnification field, or a ratio of the two \\>2.5:1), pathogenic bacteria cultured through bronchoscopy anti pollution brush (PSB), bronchoalveolar lavage fluid (BALF), lung tissue or sterile body fluid, and consistent with clinical manifestations; 2) Pathology, cytopathology, or direct microscopic examination of lung tissue specimens showing fungi and evidence of tissue damage; 3) The serum IgM antibodies of atypical pathogens or viruses change from negative to positive, or the titers of specific IgG antibodies in both acute and recovery phases show a 4-fold or more change. During the outbreak of respiratory viruses and with a history of epidemiological contact, respiratory secretions were tested positive for corresponding virus antigens, nucleic acid tests, or virus culture.\n4. obtained informed consent\n\nExclusion Criteria:\n\n1. Those who cannot understand and execute the investigation plan.\n2. Active pulmonary tuberculosis;\n3. Severely immunosuppressed patients: absolute neutrophil count \\\u003C0.5× 10\\^9\u002FL, CD4\\\u003C200\u002Fml.","ALL","18 Years","100 Years",{"count":39,"type":40},4000,"ESTIMATED","OBSERVATIONAL","The goal of this prospective and observatory study is to learn about the pathogen, clinical manifestations, prognosis, treatment and antibiotic resistance of bacteria in hospital-acquired pneumonia patients in China.\n\nThe main purposes of this study are:\n\n1. clarify the regional differences and changes over time in the pathogen spectrum and antibiotic resistance rate among HAP patients in China;\n2. build a continuously optimized nationwide HAP pathogen and antibiotic resistance surveillance network;\n3. identify the molecular epidemiology of common pathogens",[44,45],"Hospital-acquired Pneumonia","Antibiotic Resistant Infection","NOT_YET_RECRUITING","2023-08-31",{"date":49,"type":50},"2023-09-08","ACTUAL",{"date":52,"type":40},"2023-10-01",{"date":54,"type":40},"2027-12-31",{"name":5,"class":6}]